Initial characterization of stiff skin‐like syndrome in West Highland white terriers

Doelle, Maren; Linder, Keith E.; Boche, Janna; Jagannathan, Vidhya; Leeb, Tosso; Линек, Моника

doi:10.1111/vde.12316

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Histopathologically, LS in humans is characterized by overproduction of dermal collagen and other extracellular matrix proteins that replace the subcutaneous adipose tissue [ 4 ]. Similar skin conditions in companion animals have rarely been reported in the veterinary literature [ 1 , 2 , 7 ]. In this case report, we describe a linear form of LS-like disease in a young cat.…”

supporting

confidence: 57%

Collagen-enriched serpiginous skin lesion in a cat resembling the linear form of localized scleroderma in humans

Osumi

Mitsui²,

Morita³

et al. 2018

The Journal of Veterinary Medical Science

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Localized scleroderma (LS) is a sclerotic skin disorder rarely reported in the veterinary literature. We herein report the first case of a linear LS-like skin lesion in a cat. A 1-year-old castrated male Himalayan cat was presented with a 1-month history of an alopecic, indurated, serpiginous, branched skin lesion on the dorsal cervical to scapular area. The cat had no history of trauma, although a topical spot-on endectocide had been applied near the lesion. Histopathological examination revealed a focal area of hyperplastic dermal collagen with the absence of pilosebaceous units. The cutaneous lesion remained unchanged during a 2-year follow-up period. Clinical and histopathological similarities of this skin lesion with those of the linear form of LS in humans were considered.

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supporting

confidence: 57%

Collagen-enriched serpiginous skin lesion in a cat resembling the linear form of localized scleroderma in humans

Osumi

Mitsui²,

Morita³

et al. 2018

The Journal of Veterinary Medical Science

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“…Most documented cases of cutaneous fibrosis in dogs represent cicatricial alopecia or congenital/hereditary disorders, including dermatofibrosis, cutaneous sclerosis and joint stiffness in beagles and cutaneous sclerosis in West Highland white terrier . Confirmed localized scleroderma (morphea) or generalized and systemic scleroderma with circulating auto‐antibodies, a diagnostic feature in people, has not been reported in dogs.…”

Section: Discussionmentioning

confidence: 99%

Multicentric B‐cell lymphoma with presumed paraneoplastic generalized cutaneous sclerosis in a dog

Affolter

O'Brien²,

Nagle³

et al. 2020

Veterinary Dermatology

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Background Reports of dermal sclerosis in dogs include scleroderma or morphea of unknown cause, cicatricial alopecia and congenital/hereditary fibrosis. Clinical Summary A 12‐year‐old, male castrated chihuahua‐mix dog was evaluated for skin lesions of unknown duration. The dog had severe alopecia, skin thickening and marked peripheral lymphadenopathy. Lymph node cytological investigation, immunohistochemical investigation and clonality testing demonstrated an intermediate to large B‐cell lymphoma. The thickened skin had severe collagen deposition, effacing adnexal structures. The dog's lymphoma was treated but the skin lesions remained unchanged. The dog was euthanized. Conclusions and clinical importance To the best of the authors' knowledge, this is the first report of multicentric B‐cell lymphoma in a dog with concurrent diffuse cutaneous sclerosis, similar to a human paraneoplastic reaction.

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Initial characterization of stiff skin‐like syndrome in West Highland white terriers

Cited by 2 publications

References 14 publications

Collagen-enriched serpiginous skin lesion in a cat resembling the linear form of localized scleroderma in humans

Collagen-enriched serpiginous skin lesion in a cat resembling the linear form of localized scleroderma in humans

Multicentric B‐cell lymphoma with presumed paraneoplastic generalized cutaneous sclerosis in a dog

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