Initial characterization of a transgenic mouse with overexpression of the human D1-dopamine receptor in the heart
Lina Maria Rayo-Abella,
Hannes Jacob,
Britt Hofmann
et al.
Abstract:Dopamine can exert effects in the mammalian heart via five different dopamine receptors. There is controversy whether dopamine receptors increase contractility in the human heart. Therefore, we have generated mice that overexpress the human D1-dopamine receptor in the heart (D1-TG) and hypothesized that dopamine increases force of contraction and beating rate compared to wild type mice (WT). In D1-TG hearts, we ascertained the presence of D1-dopamine receptors by autoradiography using [3H]SKF 38393. The mRNA f… Show more
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