Initial bone regeneration around fenestrated implants in Beagle dogs using basic fibroblast growth factor–gelatin hydrogel complex with varying biodegradation rates

Akagawa, Yasumasa; Kubo, Takayasu; Koretake, Katsunori; Hayashi, Kazuhiko; Doi, Katsuhiko; Matsuura, Ayumu; Morita, Koji; Takeshita, Ryou; Yuan, Quan; Tabata, Yasuhiko

doi:10.1016/j.jpor.2008.08.009

Cited by 47 publications

(32 citation statements)

References 29 publications

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“…use of artificial materials such as polyglycolic acid, fibrin glue, collagen gel and carbon blocks, with the aim of filling osteochondral defects, has already been described. However, this has been seen to produce a severe inflammatory reaction (3,4,8,12,18,25,(33)(34)(35) . use of this type of material, in association with culturing of mesenchymal cells in order to boost their growth potential, seems to be the future of new advances (1,7,8,12,24,(32)(33)(34)(35) .…”

Section: Discussionmentioning

confidence: 99%

“…However, this has been seen to produce a severe inflammatory reaction (3,4,8,12,18,25,(33)(34)(35) . use of this type of material, in association with culturing of mesenchymal cells in order to boost their growth potential, seems to be the future of new advances (1,7,8,12,24,(32)(33)(34)(35) . Sugarcane biopolymer has already been used experimentally as a substitute for other tissues, in a support device for urinary incontinence (36) , as a replacement for vascular prostheses (23,37) , as a coadjuvant in wound healing (20) , as a replacement for the tympanic membrane (22) , in repairs to the dura mater (38) and in bladder tissue (39) .…”

Section: Discussionmentioning

confidence: 99%

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Estudo comparativo macroscópico dos defeitos osteocondrais produzidos em fêmures de coelhos preenchidos com gel de biopolímero da cana-de-açúcar

et al. 2011

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Objective: To study the surface, coloring, consistency, continuity and healing of osteochondral defects produced in the femoral condyles of rabbits and filled with sugar cane biopolymer gel (SCBg), after 90, 120 and 180 days, and in comparison with a control group. Method: Sixteen adult New Zealand white rabbits aged 6 to 7 months, weighing between 2 and 2.5 kg and without locomotor system abnormalities were studied. In all the animals, a defect was made in the femoral condyles of the right and left knees, measuring 3.2 mm in diameter and 4 mm in depth, using a trephine. The animals were divided into two groups: study group formed by the right knees, in which the medial and lateral condyles received implants of SCBg; and control group formed by the left knees, in which the medial and lateral condyles were allowed to Rev Bras Ortop. 2011;46(5):577-84 heal naturally. The knees were assessed 90, 120 and 180 days after the operation. After the animals had been sacrificed, the anatomical specimens were resected and placed in Bouin's solution. They were then photographed with a Nikon Coolpix 5400 ® coupled to a Nikon SM2800® stereoscopic loupe, to analyze the surface, coloring, consistency, continuity and healing. Results: The results were evaluated using the chi-square test. There were no significant differences in the macroscopic assessments of healing between the study and control groups. Conclusion: With regard to the surface, coloring, consistency, continuity and healing of the defects, the macroscopic appearance of the tissue repaired with SCBg was similar to that of the control group.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Estudo comparativo macroscópico dos defeitos osteocondrais produzidos em fêmures de coelhos preenchidos com gel de biopolímero da cana-de-açúcar

et al. 2011

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“…For example, specimens from the bFGF group showed a 2.5-fold increase in hepatocyte engraftment as compared with the control group. Similarly, the incorporation of bFGF in gelatin matrix also enhanced bone regeneration [39].…”

Section: Biomolecule Deliverymentioning

confidence: 92%

Cell and biomolecule delivery for regenerative medicine

Smith

Peter

2010

Science and Technology of Advanced Materials

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Regenerative medicine is an exciting field that aims to create regenerative alternatives to harvest tissues for transplantation. In this approach, the delivery of cells and biological molecules plays a central role. The scaffold (synthetic temporary extracellular matrix) delivers cells to the regenerative site and provides three-dimensional environments for the cells. To fulfil these functions, we design biodegradable polymer scaffolds with structural features on multiple size scales. To enhance positive cell-material interactions, we design nano-sized structural features in the scaffolds to mimic the natural extracellular matrix. We also integrate micro-sized pore networks to facilitate mass transport and neo tissue regeneration. We also design novel polymer devices and self-assembled nanospheres for biomolecule delivery to recapitulate key events in developmental and wound healing processes. Herein, we present recent work in biomedical polymer synthesis, novel processing techniques, surface engineering and biologic delivery. Examples of enhanced cellular/tissue function and regenerative outcomes of these approaches are discussed to demonstrate the excitement of the biomimetic scaffold design and biologic delivery in regenerative medicine.

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“…While looking for new advances, an extracellular polysaccharide was obtained by fermenting sugar cane molasses using the microorganism Zoogloea sp, which had already been identified in the department of antibiotics at the Federal University of Pernambuco (UFPE). The biopolymer synthesized by this bacterium has the physical characteristics of purity, elasticity and flexibility 1, [13][14][15][16] . It showed low cytotoxidity and biocompatibility in experimental studies 17 .…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the areas of osteochondral defects produced in femoral condyles of rabbits treated with sugar cane biopolymer gel

Albuquerque

Aguiar²,

Filho³

et al. 2015

Acta Cir. Bras.

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PURPOSE:To assess the histological response of damaged osteochondral tissue in the femoral condyles of rabbits after repairing the wounds with sugar cane biopolymer gel -compared to the control group. METHODS:The study investigated 16 New Zealand rabbits, at 90, 120 and 180 days after surgery. In all the animals, a lesion of 3.2 mm in diameter and 4 mm deep was induced in each right and left femoral condyle. Each animal has provided both knees, divided into medial and lateral condyle, resulting in 64 samples. 32 knees were divided into two groups: Right knee, medial and lateral condyles, filled with biopolymer; Left knee, medial and lateral condyles, unfilled. The anatomical specimens were removed, and subjected to histological techniques and morphometric and statistical analysis. RESULTS:In all the periods of the group under study an inflammatory reaction mediated by giant cells and mononuclear cells was found, while in the control group there was early healing produced by fibroblasts and few mononuclear cells with statistical significance between groups. CONCLUSION:The biopolymer gel caused an inflammatory reaction mediated by giant cells and mononuclear cells while the control group there was cicatrization mediated by fibroblasts.Key words: Osteogenesis. Cartilage. Histology. Biopolymers. Rabbits.A comparative study of the areas of osteochondral defects produced in femoral condyles of rabbits treated with sugar cane biopolymer gel

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Initial bone regeneration around fenestrated implants in Beagle dogs using basic fibroblast growth factor–gelatin hydrogel complex with varying biodegradation rates

Abstract: These results suggest that use of slow degradation-type bFGF-gelatin hydrogel complex may accelerate bone regeneration around fenestrated implants at an early stage of bone regeneration.

Cited by 47 publications

References 29 publications

Estudo comparativo macroscópico dos defeitos osteocondrais produzidos em fêmures de coelhos preenchidos com gel de biopolímero da cana-de-açúcar

Estudo comparativo macroscópico dos defeitos osteocondrais produzidos em fêmures de coelhos preenchidos com gel de biopolímero da cana-de-açúcar

Cell and biomolecule delivery for regenerative medicine

A comparative study of the areas of osteochondral defects produced in femoral condyles of rabbits treated with sugar cane biopolymer gel

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