Initial biocompatibility studies of a novel degradable polymeric bone substitute that hardens in situ

Bennett, Steven L.; Connolly, Kevin M.; Lee, Daniel R.; Jiang, Ying; Buck, David C.; Hollinger, Jeffrey O.; Gruskin, Elliott

doi:10.1016/s8756-3282(96)00130-5

Cited by 42 publications

(32 citation statements)

References 5 publications

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“…On and in scaffolds in which cells are recruited in vivo or inoculated in vitro, tissue architecture is expected to be completed in three dimensions at an early stage of implantation. [16][17][18][19][20][21] There has been active research on creating porous structures from synthetic polymers [28][29][30][31][32][33][34] and biologically derivatized macromolecules such as collagen 35,36 and gelatin 37 to serve as scaffolding. For example, fibrous nonwoven fabrics made of synthetic polymers such as poly(L-lactic acid) 28,38,39 and SPU, [40][41][42] and open-cell structured porous foams, which are fabricated by a particle-leaching technique, 25,43,44 phase inversion technique, 33,45,46 or freeze-drying technique, [47][48][49][50] have been used as microporous scaffolds.…”

Section: Discussionmentioning

confidence: 99%

Surface microarchitectural design in biomedical applications:In vivo analysis of tissue ingrowth in excimer laser-directed micropored scaffold for cardiovascular tissue engineering

Nakayama

Nishi

Ishibashi‐Ueda

et al. 2000

J. Biomed. Mater. Res.

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A micropatterned microporous segmented polyurethane film (20 x 12 mm in size, 30 micrometer thick) with four regions was prepared by excimer laser microprocessing to provide an in vivo model of transmural tissue ingrowth in an open cell-structured scaffold specially designed for cardiovascular tissue engineering. Three microporous regions had the same circular micropores (30 micrometer diameter) but different pore density arrangements (percentage of total pore area against unit area was 0.3%, 1.1%, and 4.5%), and the other region remained nonporous. The covered stent, prepared by wrapping the regionally different density-microporous film on an expandable metallic stent (approximately 3.1 mm in diameter), was delivered to the luminal surface of canine common carotid arteries and placed after expansion of the stent to a diameter of approximately 8 mm using a balloon catheter. At 4 weeks of implantation, all the covered stents (n = 10) were patent. The luminal surfaces of the covered stents were almost confluently endothelialized both in nonporous and microporous regions. Histological examination showed that the neointimal wall was formed by tissue ingrowth from host through micropores (transmural) and anastomotic sites. Thrombus formation occurred frequently in the lowest density porous region and nonporous region. With an increase in pore density, the thickness of the neointimal wall decreased. This study demonstrated how the micropore density of implanted devices influences tissue ingrowth in arterial implantation.

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Section: Discussionmentioning

confidence: 99%

Surface microarchitectural design in biomedical applications:In vivo analysis of tissue ingrowth in excimer laser-directed micropored scaffold for cardiovascular tissue engineering

Nakayama

Nishi

Ishibashi‐Ueda

et al. 2000

J. Biomed. Mater. Res.

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“…548 Similarly, Bennett et al showed that a polydioxanone-co-glycolide-based biocomposite reinforced with HA or β-TCP can be used as an injectable or moldable putty. 896 During the cross-linking reaction following injection, carbon dioxide is released, allowing the formation of interconnected pores. Furthermore, HA/poly(L-lactide-co-ε-caprolactone) biocomposite microparticles were fabricated as an injectable scaffold via the Pickering emulsion route in the absence of any molecular surfactants.…”

Section: Injectable Bone Substitutes (Ibs)mentioning

confidence: 99%

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Dorozhkin¹

2011

Biomatter

153

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“…Injectable composites can be formed with b-TCP to improve mechanical integrity [453]. Similarly, Bennett et al [733] showed that a polydioxanone-co-glycolide-based biocomposite reinforced with HA or b-TCP can be used as an injectable or moldable putty. During the crosslinking reaction following injection, carbon dioxide is released allowing the formation of interconnected pores.…”

Section: Biocomposites With Collagenmentioning

confidence: 99%