Initial and post-treatment total oxidant–antioxidant status and oxidative stress index in male patients with manic episode

Kalelioğlu, Tevfik; Genç, Abdullah; Karamustafalıoğlu, Nesrin; Tasdemir, Akif; Cansız, Alparslan; İncir, Said; İlnem, Mehmet Cem; Emül, Murat

doi:10.1016/j.psychres.2014.04.021

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…They considered that the increased OSI levels might be due to the use of antipsychotics. In the same study (28), similar with our results, no significant difference was reported between ME patients and HCs in terms of serum TOS and OSI levels. Yumru et al (13) investigated TAS, TOS, and OSI levels of EU BD patients according to subtypes of disorder (BD I, BD II, and previous antidepressant-induced mania).…”

Section: Discussionsupporting

confidence: 91%

“…In the present study, statistical analysis revealed no significant difference between EU patients, ME patients, and HCs in terms of serum TAS, TOS, and OSI levels. Kalelioglu et al (28) previously compared these oxidative parameters of ME patients and HCs, but did not include any EU patient in their study design. They detected decreased TAS values in ME patients than in HCs and reported that OSI values were increased following not electroconvulsive therapy but antipsychotic treatment.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index

Yirün

Ünal

Şen

et al. 2016

Arch Neuropsychiatr

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index

Yirün

Ünal

Şen

et al. 2016

Arch Neuropsychiatr

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“…It is now recognized across a wide range of psychiatric disorders such as schizophrenia (Sz), bipolar disorder (BD), and major depressive disorder (MDD). While the present etiological understanding of these disorders is dominated by theories of altered neurotransmission, there is increasing evidence for the involvement of disrupted antioxidant defense system and presence of oxidative stress (OS) in their pathophysiology. − Ever since the role of free radicals in the pathogenesis of Sz was proposed in the 1950s, research in this area has seen a substantial growth . It has been previously established that OS is a contributing factor in causing and aggravating severe psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Schizophrenia, Bipolar and Major Depressive Disorders: Overview of Clinical Features, Neurotransmitter Alterations, Pharmacological Interventions, and Impact of Oxidative Stress in the Disease Process

Mandal

Gaur

Roy

et al. 2022

ACS Chem. Neurosci.

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Psychiatric disorders are one of the leading causes of disability worldwide and affect the quality of life of both individuals and the society. The current understanding of these disorders points toward receptor dysfunction and neurotransmitter imbalances in the brain. Treatment protocols are hence oriented toward normalizing these imbalances and ameliorating the symptoms. However, recent literature has indicated the possible role of depleted levels of antioxidants like glutathione (GSH) as well as an alteration in the levels of the pro-oxidant, iron in the pathogenesis of major psychiatric diseases, viz., schizophrenia (Sz), bipolar disorder (BD), and major depressive disorder (MDD). This review aims to highlight the involvement of oxidative stress (OS) in these psychiatric disorders. An overview of the clinical features, neurotransmitter abnormalities, and pharmacological treatments concerning these psychiatric disorders has also been presented. Furthermore, it attempts to synthesize literature from existing magnetic resonance spectroscopy (MRS) and quantitative susceptibility mapping (QSM) studies for these disorders, assessing GSH and iron, respectively. This manuscript is a sincere attempt to stimulate research discussion to advance the knowledge base for further understanding of the pathoetiology of Sz, BD, and MDD.

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“…Total antioxidant status and TOS levels were measured by 3 studies by independent groups. 32 - 34 Kalelioglu et al 32 have enrolled 68 patients with acute mania. Twenty-two of the patients had antipsychotic and ECT treatment, while 46 of the patients had only antipsychotic treatment.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of the Literature Regarding the Relationship Between Oxidative Stress and Electroconvulsive Therapy

Atagün¹,

Canbek²

2022

ALPHA PSYCHIATRY

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Objective Brain’s aerobic energy metabolism, abundance of the fatty acids and unsaturated lipids, generation of Reactive Oxygen Species (ROS) by hormones, physiological roles of transition metals (i.e., iron and copper), and free radicals in the nervous system may cause inclination to oxidative stress in psychiatric disorders. Electroconvulsive therapy (ECT) may cause oxidative stress by the electrical field or by the induced seizure. It was aimed to review the literature in terms of the influence of ECT on levels of oxidant and antioxidant compounds. Methods The literature search was performed with the keywords that were oxidative stress or "DNA damage" or "RNA damage" or "lipid peroxidase" or "superoxide dismutase" or "catalase" or "glutathione" or "nitrite" or "nitric oxide" and "electroconvulsive therapy" or "electroconvulsive shock" or "electroconvulsive seizure". Twenty of 1480 records were included. Results Eleven studies were performed in human subjects, whereas 9 studies were performed in rats. Human studies are conducted with serum, plasma, or urine samples; rat studies include brain tissues from various sites. In rats, four independent studies showed increased levels of lipid oxidation markers, and four independent studies reported increased levels of oxidative stress markers in brain samples. In human studies, studies were performed with circulating blood samples and the results were more inconsistent. Conclusion Although some markers like superoxide dismutase or thioredoxin imply that ECT may increase the balance for oxidative stress, this notion is not supported by other markers of ECT. The current literature does not clearly suggest that the ECT is associated with oxidative stress in psychiatric disorders. Further studies with similar methods should be performed in big samples.

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Initial and post-treatment total oxidant–antioxidant status and oxidative stress index in male patients with manic episode

Cited by 6 publications

References 13 publications

Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index

Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index

Schizophrenia, Bipolar and Major Depressive Disorders: Overview of Clinical Features, Neurotransmitter Alterations, Pharmacological Interventions, and Impact of Oxidative Stress in the Disease Process

A Systematic Review of the Literature Regarding the Relationship Between Oxidative Stress and Electroconvulsive Therapy

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