Initial Analysis of the International Association For the Study of Lung Cancer Mesothelioma Database

Rusch, Valerie W.; Giroux, Dorothy J.; Kennedy, Catherine; Ruffini, Enrico; Cangır, Ayten; Rice, David C.; Pass, Harvey I.; Asamura, Hisao; Waller, David; Edwards, John; Weder, Walter; Hoffmann, Hans; Meerbeeck, Jan P. van

doi:10.1097/jto.0b013e31826915f1

Cited by 326 publications

(283 citation statements)

References 46 publications

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“…To obtain more meaningful survival data on this rare tumour, the International Association for the Study of Lung Cancer (IASLC) retrospectively collected 3101 cases from 15 centres on four continents [13]. Currently, this is the largest international database of mesothelioma patients, which has recently been analysed [13].…”

Section: Prognostic Factorsmentioning

confidence: 99%

“…For this reason, newer treatment modalities are currently being explored, mostly consisting of multimodality therapy comprising chemotherapy, radiotherapy and surgery [12,13]. The precise role and type of surgery remain highly controversial and no precise guidelines are currently available due to the lack of large randomised controlled trials [14].…”

Section: Introductionmentioning

confidence: 99%

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Multimodal management of malignant pleural mesothelioma: where are we today?

Schil

Opitz²,

Weder³

et al. 2014

European Respiratory Journal

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The prognosis of patients with malignant pleural mesothelioma remains poor and although it is clear that multimodal therapy is necessary to improve long-term results, precise treatment schemes have not yet been unequivocally established. Single-modality therapy does not have a major impact on long-term survival and combined-modality therapies are being further evaluated. However, the relative contributions of chemotherapy, radiotherapy and surgery have not been clearly determined at the present time. Moreover, the extent of resection and precise surgical procedure remain a highly debated topic. To better compare and combine results from different institutions and trials, uniform definitions of surgical procedures including extrapleural pneumonectomy and different forms of pleurectomy have recently been introduced. Due to the relatively higher morbidity and mortality of extrapleural pneumonectomy, there is currently a shift towards pleurectomy/decortication when a macroscopic complete resection of all tumour can be obtained by this procedure. In most recent trials, induction chemotherapy was administered to improve surgical resection rates but pathological complete responses are infrequently observed. The role of post-operative radiotherapy has to be further elucidated.Further treatment options that are currently explored include hyperthermic intrapleural chemotherapy, immunotherapy, gene therapy and photodynamic therapy. However, no randomised comparisons are available yet. @ERSpublications Treatment of malignant pleural mesothelioma remains controversial

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Section: Prognostic Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multimodal management of malignant pleural mesothelioma: where are we today?

Schil

Opitz²,

Weder³

et al. 2014

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

“…A subset of patients with epithelioid malignant mesothelioma limited to the hemithorax may benefit from an approach that includes surgery involving extrapleural pneumonectomy or a lung-preserving operation such as pleurectomy/decortication [21]. Regardless of the approach, the goal of surgery is macroscopic complete resection.…”

Section: Imaging With Indocyanine Green For Intraoperative Detection mentioning

confidence: 99%

“…Although MRI does have superior tissue contrast, subtle local invasion can still be a challenge to detect with imaging. Limitations in imaging are partially responsible for the significant upstaging of disease that occurs in patients with mesothelioma who undergo pleurectomy; in a study by Rusch et al, for example, as many as 80% of patients with stage 1 and 2 disease and 23% of patients with stage 3 disease were upstaged post-operatively [21].…”

Section: Utility Of Delayed Phase Enhancement Mrimentioning

confidence: 99%

Imaging in pleural mesothelioma: A review of the 11th International Conference of the International Mesothelioma Interest Group

et al. 2013

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Imaging plays an important role in the detection, diagnosis, staging, response assessment, and surveillance of malignant pleural mesothelioma. The etiology, biology, and growth pattern of mesothelioma present unique challenges for each modality used to capture various aspects of this disease. Clinical implementation of imaging techniques and information derived from images continue to evolve based on active research in this field worldwide. This paper summarizes the imaging-based research presented orally at the 2016 International Conference of the International Mesothelioma Interest Group (iMig) in Birmingham, United Kingdom, held May 1-4, 2016. Presented topics included intraoperative near-infrared imaging of mesothelioma to aid the assessment of resection completeness, an evaluation of tumor enhancement improvement with increased time delay between contrast injection and image acquisition in standard clinical magnetic resonance imaging (MRI) scans, the potential of early contrast enhancement analysis to provide MRI with a role in mesothelioma detection, the differentiation of short-and long-term Corresponding Author: Samuel G. Armato III, Ph.D., Department of Radiology, The University of Chicago, 5841 South Maryland Ave., MC 2026, Chicago, IL, USA 60637, s-armato@uchicago.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HHS Public Access Author ManuscriptAuthor Manuscript Author ManuscriptAuthor Manuscript survivors based on MRI tumor volume and histogram analysis, the response-assessment potential of hemodynamic parameters derived from dynamic contrast-enhanced computed tomography (DCE-CT) scans, the correlation of CT-based tumor volume with the post-surgical tumor specimen weight, and consideration of the need to update the mesothelioma tumor response assessment paradigm.

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“…Histology and TNM staging show the highest prognostic significance although these classifications are rather robust and not precise [8].…”

Section: Introductionmentioning

confidence: 99%

Reproducibility of histological subtyping of malignant pleural mesothelioma

et al. 2014

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Initial Analysis of the International Association For the Study of Lung Cancer Mesothelioma Database

Abstract: This is the largest international database examining outcomes in surgically managed MPM patients. Survival differences reported from smaller databases are confirmed but suggest the need to revise tumor and node staging.

Cited by 326 publications

References 46 publications

Multimodal management of malignant pleural mesothelioma: where are we today?

Multimodal management of malignant pleural mesothelioma: where are we today?

Imaging in pleural mesothelioma: A review of the 11th International Conference of the International Mesothelioma Interest Group

Reproducibility of histological subtyping of malignant pleural mesothelioma

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