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2006
DOI: 10.1016/j.tca.2005.10.012
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Inhibitory study of some novel Schiff base derivatives on Staphylococcus aureus by microcalorimetry

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Cited by 62 publications
(21 citation statements)
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“…The high positive value of the intercept added to low coefficients of the dependant variables in equations A, B, E and F suggested that hydrophobicity was the major constraint in achieving very low MIC value of the substrates. This observation did not correspond to what is reported for other Schiff bases [18] wherein the authors found a positive correlation between hydrophobicity and antibacterial activity. This difference in activity in relation to hydrophobicity in quinazolone derived Schiff base(s) and the earlier reported Schiff base(s) could be due to the differences in active sites.…”
Section: Preliminary Qsar Studycontrasting
confidence: 97%
“…The high positive value of the intercept added to low coefficients of the dependant variables in equations A, B, E and F suggested that hydrophobicity was the major constraint in achieving very low MIC value of the substrates. This observation did not correspond to what is reported for other Schiff bases [18] wherein the authors found a positive correlation between hydrophobicity and antibacterial activity. This difference in activity in relation to hydrophobicity in quinazolone derived Schiff base(s) and the earlier reported Schiff base(s) could be due to the differences in active sites.…”
Section: Preliminary Qsar Studycontrasting
confidence: 97%
“…Microcalorimetry currently is one of the most important techniques in thermochemistry and thermodynamic studies due to its high sensitivity, accuracy, and its non-invasive, non-destructive nature. It also allows real-time, on-line and automated analysis [20][21][22][23][24][25] . One of the most prominent characters of the growth of the microorganisms is the production of heat.…”
Section: Introductionmentioning
confidence: 99%
“…Schiff bases are compounds with the structure consisting of a C=N bond, generally formed by condensation of an amine and active carbonyl group, initially developed by Hugo Schiff [1] [2]. Schiff base ligands are easily synthesized and form complexes with almost all metal ions in various oxidation states [3] [4].…”
Section: Introductionmentioning
confidence: 99%
“…The obtained solids are further investigated by elemental analysis and UV-Vis titration that confirm the formation of desired complexes. Recrystallization of the Co(II) complex in DMSO results in the cleavage of C=N bond to yield (2). The outline of the synthetic procedure is given in Scheme 1.…”
Section: Introductionmentioning
confidence: 99%