Inhibitory Pathway for Female Sexual Behavior in Male Rat Brain: Effect of Medial Forebrain Bundle (MFB) Cuts.

Suzuki, Kaoru; Yamanouchi, Korehito

doi:10.1262/jrd.44.393

Cited by 3 publications

(2 citation statements)

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“…Neural fibers projecting from the LS join the medial forebrain bundle (MFB) (Veening et al, 1982 ). Transection of the MFB at the suprachiasmatic level enhances lordosis in female rats (Yamanouchi and Arai, 1989 ) and induces lordosis in male rats (Yamashita Suzuki and Yamanouchi, 1998 ). Therefore, it is considered that lordosis-inhibiting neurons of the LS terminate at the brain stem after the neural fibers pass through the MFB.…”

Section: Lordosis-inhibiting System In the Lsmentioning

confidence: 99%

“…To determine the lordosis-inhibiting neural tracts from the LS to MCG, we traced the neural projections from the LSi to the MCG in E 2 -treated castrated male rats using Phaseolus vulgaris leucoagglutinin (PHAL), an anterograde neurotracer (Tsukahara and Yamanouchi, 2001 ) (Figure 3A ). Neural tracts from the LS to MFB (Figures 3A-1,2 ) are essential for lordosis-inhibiting LSi neurons to function, because the lordosis reflex is induced in male rats by transection of the ventral area of the septal region (Yamanouchi and Arai, 1985 ) and by transection of the MFB (Yamashita Suzuki and Yamanouchi, 1998 ). Similar surgical manipulations enhance lordotic activity in female rats (Yamanouchi and Arai, 1977 , 1989 , 1990 ).…”

Section: Lordosis-inhibiting System In the Lsmentioning

confidence: 99%

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Neuroanatomy and sex differences of the lordosis-inhibiting system in the lateral septum

2014

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Female sexual behavior in rodents, termed lordosis, is controlled by facilitatory and inhibitory systems in the brain. It has been well demonstrated that a neural pathway from the ventromedial hypothalamic nucleus (VMN) to the midbrain central gray (MCG) is essential for facilitatory regulation of lordosis. The neural pathway from the arcuate nucleus to the VMN, via the medial preoptic nucleus, in female rats mediates transient suppression of lordosis, until female sexual receptivity is induced. In addition to this pathway, other regions are involved in inhibitory regulation of lordosis in female rats. The lordosis-inhibiting systems exist not only in the female brain but also in the male brain. The systems contribute to suppression of heterotypical sexual behavior in male rats, although they have the potential ability to display lordosis. The lateral septum (LS) exerts an inhibitory influence on lordosis in both female and male rats. This review focuses on the neuroanatomy and sex differences of the lordosis-inhibiting system in the LS. The LS functionally and anatomically links to the MCG to exert suppression of lordosis. Neurons of the intermediate part of the LS (LSi) serve as lordosis-inhibiting neurons and project axons to the MCG. The LSi-MCG neural connection is sexually dimorphic, and formation of the male-like LSi-MCG neural connection is affected by aromatized testosterone originating from the testes in the postnatal period. The sexually dimorphic LSi-MCG neural connection may reflect the morphological basis of sex differences in the inhibitory regulation of lordosis in rats.

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Section: Lordosis-inhibiting System In the Lsmentioning

confidence: 99%

Section: Lordosis-inhibiting System In the Lsmentioning

confidence: 99%

Neuroanatomy and sex differences of the lordosis-inhibiting system in the lateral septum

2014

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Neurohistological and behavioral evidence for lordosis-inhibiting tract from lateral septum to periaqueductal gray in male rats

Tsukahara

Yamanouchi

2001

J. Comp. Neurol.

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To verify the anatomical and functional connection of the lateral septum (LS) and periaqueductal gray (PAG) in inhibiting female sexual behavior, lordosis, in male rats, retrograde (Fluoro-Gold, FG) or anterograde (Phaseolus vulgaris-leucoagglutinin, PHA-L) tracer was injected into the PAG or LS on the right side, respectively, and FG-labeled cells or PHA-L-labeled axons in the forebrain and mesencephalon were determined in estrogen-treated castrated male rats. A ventral cut (VC) of the septum and a behavioral test were also conducted in some FG-injected rats. Furthermore, lordosis behavior was observed after chemical destruction of the septum by ibotenate. As a result, the lordosis quotient (LQ) in VC males was higher than that in control males without VC. FG-labeled neuronal cell bodies were found in the ipsilateral intermediate part of the LS in the control males but not in this area of the VC males. When neuronal cells in the intermediate part of the bilateral LS were completely destroyed by ibotenate, the LQ was higher than that in sham-lesioned male rats. These results suggest that a direct neural connection of the intermediate LS to the PAG has an inhibitory role in regulating lordosis in male rats. In addition, neuronal cell bodies in the intermediate LS exert an inhibitory influence. In the PHA-L experiment, labeled axons were seen in the ventral part of the LS, the medial forebrain bundle at the chiasmatic level, the lateral hypothalamus, the median region of the mesencephalon, and the rostral PAG in the side ipsilateral to the tracer injection site of the LS. Thus, these areas are thought to be involved in the pathway for lordosis-inhibition from the intermediate part of the LS to the PAG in male rats.

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Decrease of Serotonin and Metabolite in the Forebrain and Facilitation of Lordosis by Dorsal Raphe Nucleus Lesions in Male Rats.

Kakeyama

Umino²,

Nishikawa³

et al. 2002

Endocr J

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In castrated male rats, a radiofrequency lesion was made in the dorsal raphe nucleus (DRL) and lordosis behavior was observed following treatment with estrogen. After the behavioral test, brains were removed and the contents of 5-HT and 5-HIAA in the forebrain were measured by high pressure liquid chromatography (HPLC). In the results, only 2 of 16 control males without brain surgery showed lordosis, and the mean lordosis quotient (LQ) was extremely low when compared to that in control females. In contrast, all male rats with DRL displayed lordosis and the mean LQ was higher than that of control males without brain surgery but lower than that in control females (P < 0.001). In the DRL males, 5-HT and 5-HIAA contents in the septum (SPT), the preoptic area (POA), the ventromedial hypothalamus (VMH) and the striatum (STM) were lower than those in control male and female groups (P < 0.001). These results suggest that the dorsal raphe nucleus prevents male rats from showing lordosis by serotonergic influence in the forebrain. In addition, HPLC results showed that levels of the 5-HT in the SPT, the POA and the VMH in the female group were higher than those in the control male group (P < 0.05). In female rats, the POA (P < 0.01) and the VMH (P < 0.05) contained larger 5-HT than those in the SPT and the STM, but there were no difference of 5-HT contents in the male rat.

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Inhibitory Pathway for Female Sexual Behavior in Male Rat Brain: Effect of Medial Forebrain Bundle (MFB) Cuts.

Cited by 3 publications

References 24 publications

Neuroanatomy and sex differences of the lordosis-inhibiting system in the lateral septum

Neuroanatomy and sex differences of the lordosis-inhibiting system in the lateral septum

Neurohistological and behavioral evidence for lordosis-inhibiting tract from lateral septum to periaqueductal gray in male rats

Decrease of Serotonin and Metabolite in the Forebrain and Facilitation of Lordosis by Dorsal Raphe Nucleus Lesions in Male Rats.

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