Inhibitory Neural Circuits in the Mammalian Auditory Midbrain

Ono, Munenori

doi:10.1177/1179069518818230

Cited by 4 publications

(2 citation statements)

References 159 publications

(247 reference statements)

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“…The inferior colliculus is the major auditory nucleus of the midbrain, and the excitatory and inhibitory synaptic input helps in shaping the neural response of sound in the midbrain 49 . Studies have affirmed a strong correlation between hippocampus and midbrain, specifically ventral tegmental and medial subtantia nigra, which plays a role in memory formation 49 , 50 . Together, it might induce GM alteration in the midbrain of the Pandits in the long-term.…”

Section: Discussionmentioning

confidence: 99%

Extensive long-term verbal memory training is associated with brain plasticity

Kumar

Singh

Paddakanya

2021

Sci Rep

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The human brain has a remarkable capacity to store a lifetime of information through visual or auditory routes. It excels and exceeds any artificial memory system in mixing and integrating multiple pieces of information encoded. In this study, a group of verbal memory experts was evaluated by multiple structural brain analysis methods to record the changes in the brain structure. The participants were professional Hindu pandits (priests/scholars) trained in reciting Vedas and other forms of Hindu scriptures. These professional Vedic priests are experts in memorization and recitation of oral texts with precise diction. Vedas are a collection of hymns. It is estimated that there are more than 20,000 mantras and shlokas in the four Vedas. The analysis included the measurement of the grey and white matter density, gyrification, and cortical thickness in a group of Vedic pandits and comparing these measures with a matched control group. The results revealed an increased grey matter (GM) and white matter (WM) in the midbrain, pons, thalamus, parahippocampus, and orbitofrontal regions in pandits. The whole-brain corelation analysis using length of post-training teaching duration showed significant correlation with the left angular gyrus. We also found increased gyrification in the insula, supplementary motor area, medial frontal areas, and increased cortical thickness (CT) in the right temporal pole and caudate regions of the brain. These findings, collectively, provide unique information regarding the association between crucial memory regions in the brain and long-term practice of oral recitation of scriptures from memory with the proper diction that also involved controlled breathing.

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Section: Discussionmentioning

confidence: 99%

Extensive long-term verbal memory training is associated with brain plasticity

Kumar

Singh

Paddakanya

2021

Sci Rep

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“…GABAergic neurons comprise about 20–30% of the inhibitory neurons in the IC of rodents [ 5 , 6 , 7 , 8 ], and 15% in the human IC [ 9 ]. Despite the lower proportion of GABAergic cells in the IC, inhibition plays a critical role in shaping IC neuronal responses [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Isl1 under the Pax2 Promoter, Leads to Impaired Sound Processing and Increased Inhibition in the Inferior Colliculus

Chumak

Tóthová

Filova

et al. 2021

IJMS

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The LIM homeodomain transcription factor ISL1 is essential for the different aspects of neuronal development and maintenance. In order to study the role of ISL1 in the auditory system, we generated a transgenic mouse (Tg) expressing Isl1 under the Pax2 promoter control. We previously reported a progressive age-related decline in hearing and abnormalities in the inner ear, medial olivocochlear system, and auditory midbrain of these Tg mice. In this study, we investigated how Isl1 overexpression affects sound processing by the neurons of the inferior colliculus (IC). We recorded extracellular neuronal activity and analyzed the responses of IC neurons to broadband noise, clicks, pure tones, two-tone stimulation and frequency-modulated sounds. We found that Tg animals showed a higher inhibition as displayed by two-tone stimulation; they exhibited a wider dynamic range, lower spontaneous firing rate, longer first spike latency and, in the processing of frequency modulated sounds, showed a prevalence of high-frequency inhibition. Functional changes were accompanied by a decreased number of calretinin and parvalbumin positive neurons, and an increased expression of vesicular GABA/glycine transporter and calbindin in the IC of Tg mice, compared to wild type animals. The results further characterize abnormal sound processing in the IC of Tg mice and demonstrate that major changes occur on the side of inhibition.

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Hearing loss-related altered neuronal activity in the inferior colliculus

Ono,

Ito

2024

Hearing Research

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Inhibitory Neural Circuits in the Mammalian Auditory Midbrain

Cited by 4 publications

References 159 publications

Extensive long-term verbal memory training is associated with brain plasticity

Extensive long-term verbal memory training is associated with brain plasticity

Overexpression of Isl1 under the Pax2 Promoter, Leads to Impaired Sound Processing and Increased Inhibition in the Inferior Colliculus

Hearing loss-related altered neuronal activity in the inferior colliculus

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