Inhibitory network properties shaping the light evoked responses of 
cat alpha retinal ganglion cells

O’Brien, Brendan J.; Richardson, Randal; Berson, David M.

doi:10.1017/s0952523803204016

Cited by 29 publications

(48 citation statements)

References 67 publications

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“…Thus, the distinct inhibitory receptors on rod bipolar cell terminals shape the flow of information to A17 amacrine cells in separate ways. GABA and glycine signals originate in separate types of amacrine cells, which potentially have different spatial extents (Pourcho and Goebel, 1983;Vaney, 1990;Menger et al, 1998;O'Brien et al, 2003), but is not known whether GABA A and GABA C receptor-mediated signals originate from the same or separate amacrine cells. These separate signaling pathways could be independently modulated, suggesting an additional diversity for controlling glutamate release from rod bipolar cells.…”

Section: Roles Of Inhibition On Signal Processingmentioning

confidence: 99%

Receptor and Transmitter Release Properties Set the Time Course of Retinal Inhibition

Eggers

Lukasiewicz

2006

J. Neurosci.

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Synaptic inhibition is determined by the properties of postsynaptic receptors, neurotransmitter release, and clearance, but little is known about how these factors shape sensation-evoked inhibition. The retina is an ideal system to investigate inhibition because it can be activated physiologically with light, and separate inhibitory pathways can be assayed by recording from rod bipolar cells that possess distinct glycine, GABA A , and GABA C receptors (R). We show that receptor properties differentially shape spontaneous IPSCs, whereas both transmitter release and receptor properties shape light-evoked (L) IPSCs. GABA C R-mediated IPSCs decayed the slowest, whereas glycineR-and GABA A R-mediated IPSCs decayed more rapidly. Slow GABA C Rs determined the L-IPSC decay, whereas GABA A Rs and glycineRs, which mediated rapid onset responses, determined the start of the L-IPSC. Both fast and slow inhibitory inputs distinctly shaped the output of rod bipolar cells. The slow GABA C Rs truncated glutamate release, making the A17 amacrine cell L-EPSCs more transient, whereas the fast GABA A R and glycineRs reduced the initial phase of glutamate release, limiting the peak amplitude of the L-EPSC. Estimates of transmitter release time courses suggested that glycine release was more prolonged than GABA release. The time course of GABA release activating GABA C Rs was slower than that activating GABA A Rs, consistent with spillover activation of GABA C Rs. Thus, both postsynaptic receptor and transmitter release properties shape light-evoked inhibition in retina.

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Section: Roles Of Inhibition On Signal Processingmentioning

confidence: 99%

Receptor and Transmitter Release Properties Set the Time Course of Retinal Inhibition

Eggers

Lukasiewicz

2006

J. Neurosci.

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“…Local inhibition from small diameter, non-spiking amacrine cells, whose effective time constants are on the order of tens of ms, would be minimally recruited by high frequency stimulation. Moreover, the suppression of narrow field amacrine cells via axon-mediated inhibition (O'Brien et al, 2003) further amplifies ganglion cell responses to high frequency stimulation via disinhibition. Finally, local gap junctions and long-range synaptic interactions between the axon-bearing amacrine cells help to sharpen the time course of their widely distributed inhibition, thus sharpening the corresponding HFR peak.…”

Section: Discussionmentioning

confidence: 99%

A high frequency resonance in the responses of retinal ganglion cells to rapidly modulated stimuli: A computer model

et al. 2006

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Brisk Y-type ganglion cells in the cat retina exhibit a high frequency resonance (HFR) in their responses to large, rapidly modulated stimuli. We used a computer model to test whether negative feedback mediated by axon-bearing amacrine cells onto ganglion cells could account for the experimentally observed properties of HFRs. Temporal modulation transfer functions (tMTFs) recorded from model ganglion cells exhibited HFR peaks whose amplitude, width, and locations were qualitatively consistent with experimental data. Moreover, the wide spatial distribution of axon-mediated feedback accounted for the observed increase in HFR amplitude with stimulus size. Model phase plots were qualitatively similar to those recorded from Y ganglion cells, including an anomalous phase advance that in our model coincided with the amplification of low-order harmonics that overlapped the HFR peak. When axon-mediated feedback in the model was directed primarily to bipolar cells, whose synaptic output was graded, or else when the model was replaced with a simple cascade of linear filters, it was possible to produce large HFR peaks but the region of anomalous phase advance was always eliminated, suggesting the critical involvement of strongly non-linear feedback loops. To investigate whether HFRs might contribute to visual processing, we simulated high frequency ocular tremor by rapidly modulating a naturalistic image. Visual signals riding on top of the imposed jitter conveyed an enhanced representation of large objects. We conclude that by amplifying responses to ocular tremor, HFRs may selectively enhance the processing of large image features.

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“…Generally, the RF surround inhibition is shaped by GABA and the ACs that mediate it are the widefield ACs (Protti & Llano, 1998;Hartveit, 1999;Flores-Herr et al, 2001;O'Brien et al,2003;Roska et al, 2006). In contrast, local feedforward inhibition onto the RF center is mediated by narrow-field glycinergic ACs (Menger et al, 1998;O'Brien et al, 2003;Nobles et al, 2012).…”

Section: Feedforward Inhibition Occurs When Acsmentioning

confidence: 99%

“…There were very few tdTomato+ axons that terminated in the dLGN, a target of M2 GCs (Schmidt et al, 2011;Fig. 4.8c). Other known targets of ipGCs include the intergeniculate leaflet (IGL) and ventral LGN (vLGN) (Berson et al, 2003;Chen et al, 2011). The IGL and vLGN were labeled in the TRPV1 cre -AAV (Fig.…”

Section: Trpv1 Was Expressed In the Brn3b Negative Subclass Of M1 Ipgcsmentioning

confidence: 99%

“…1.7; Barlow, 1953, Rodieck & Stone, 1965Enroth-Cugell & Lennie, 1975). Generally, the RF surround inhibition is shaped by GABA and the ACs that mediate it are the widefield ACs (Protti & Llano, 1998;Hartveit, 1999;Flores-Herr et al, 2001;O'Brien et al,2003;Roska et al, 2006). In contrast, local feedforward inhibition onto the can be evoked and RF surround contributions isolated and measured using an annular stimulus ( Fig.…”

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confidence: 99%

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Transient receptor potential cation channel, subfamilies V, member 1 (TRPV1) and M, member 1 (TRPM1) contribute to neural signaling in mouse retina.

Noel¹

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Transient receptor potential cation channel, subfamilies V, member 1 (TRPV1) and M, member 1 (TRPM1) contribute to neural signaling in mouse retina. Jennifer Noel University of LouisvilleFollow this and additional works at: https://ir.library.louisville.edu/etd Part of the Biology Commons, and the Molecular and Cellular Neuroscience CommonsThis Doctoral Dissertation is brought to you for free and open access by ThinkIR: The University of Louisville's Institutional Repository. It has been accepted for inclusion in Electronic Theses and Dissertations by an authorized administrator of ThinkIR: The University of Louisville's Institutional Repository. This title appears here courtesy of the author, who has retained all other copyrights. For more information, please contact thinkir@louisville.edu. Recommended CitationNoel, Jennifer, "Transient receptor potential cation channel, subfamilies V, member 1 (TRPV1) and M, member 1 (TRPM1) contribute to neural signaling in mouse retina." (2016) Trp channels modulate the responses of retinal neurons within specific pathways..The study of the expression and function of the majority of Trp channels in the retina is largely in its infancy. My dissertation first investigated the expression and function of the transient receptor potential vanilloid-1 (TRPV1) receptor/channel in the retina. TRPV1, the first cloned and most highly studiedTrp channel in the peripheral nervous system, is a non-selective cation channel with an affinity for Ca 2+ . The channel can be activated by capsaicin, acid, endovanilloids, noxious heat or pressure (Moreira et al., 2012). Located on the peripheral and central terminals of nociceptive fibers in the PNS and in limited areas of the CNS (Cavanaugh et al, 2011b). TRPV1 plays a role in inflammation, chronic pain, nociceptor sensitization and desensitization, long-term depression vi and potentiation, and apoptosis. The role of TRPV1 in the retina is not known.Using the electroretinogram (ERG), a mass potential that assesses the function of photoreceptors and bipolar cells, the TRPV1 knockout mouse appears normal.However, TRPV1 is thought to play a role in calcium regulation and glaucoma (Sappington et al., 2009& Leonelli et al., 2010 so we investigated its role in normal visual transduction in the inner retina. To investigate TRPV1 modulation, Irecorded GC spiking responses to light stimuli from mice which either express or lack TRPV1 protein. I found that TRPV1 is critical for:1. GC responses to dim light. Sustained responses to light3. Surround suppression of GCs to large spots. (LRIT3), a novel protein component in the mGluR6-TRPM1 signalplex that was found mutated within cCSNB patients and a knockout mouse (Zeitz et al., 2013; Neuillé et al., 2014). The function of LRIT3 within the cascade remains unknown.To better understand the role of LRIT3, we examined retinal structure and function. We compared the structure of the pre and postsynaptic elements in the OPL of WT and Lrit3 -/-mice using a variety of antibodies and with confocal microscopy. We as...

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Inhibitory network properties shaping the light evoked responses of cat alpha retinal ganglion cells

Cited by 29 publications

References 67 publications

Receptor and Transmitter Release Properties Set the Time Course of Retinal Inhibition

Receptor and Transmitter Release Properties Set the Time Course of Retinal Inhibition

A high frequency resonance in the responses of retinal ganglion cells to rapidly modulated stimuli: A computer model

Transient receptor potential cation channel, subfamilies V, member 1 (TRPV1) and M, member 1 (TRPM1) contribute to neural signaling in mouse retina.

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