Inhibitory Mechanism of 10-Hydroxy-trans-2-decenoic Acid (Royal Jelly Acid) Against Lipopolysaccharide- and Interferon-β-Induced Nitric Oxide Production

Sugiyama, Tsuyoshi; Takahashi, Keita; Kuzumaki, Akihiro; Tokoro, Shunji; Neri, Paola; Mori, Hiroshi

doi:10.1007/s10753-012-9556-0

Cited by 41 publications

(32 citation statements)

References 24 publications

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“…Previous research has demonstrated that 10-H2DA could inhibit NF- κ B activation via suppressing NO production and I κ B- ζ mRNA expression and transcription stimulated by LPS and IFN- β . Also, immunoblotting revealed that 10-H2DA did not inhibit LPS-induced IKK- α phosphorylation and I κ B α degradation [30]. In our study, 10-H2DA showed modest attenuating effects on I κ B α and enhanced the phosphorylation of p65, suggesting that 10-H2DA regulated LPS stimulation through more than one single pathway.…”

Section: Discussionmentioning

confidence: 49%

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In VitroAnti-Inflammatory Effects of Three Fatty Acids from Royal Jelly

Chen

Wang

Zhang

et al. 2016

Mediators of Inflammation

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Trans-10-hydroxy-2-decenoic acid (10-H2DA), 10-hydroxydecanoic acid (10-HDAA), and sebacic acid (SEA) are the three major fatty acids in royal jelly (RJ). Previous studies have revealed several pharmacological activities of 10-H2DA and 10-HDAA, although the anti-inflammatory effects and underlying mechanisms by which SEA acts are poorly understood. In the present study, we evaluated and compared the in vitro anti-inflammatory effects of these RJ fatty acids in lipopolysaccharide-stimulated RAW 264.7 macrophages. The results showed that 10-H2DA, 10-HDAA, and SEA had potent, dose-dependent inhibitory effects on the release of the major inflammatory-mediators, nitric oxide, and interleukin-10, and only SEA decreased TNF-α production. Several key inflammatory genes have also been modulated by these RJ fatty acids, with 10-H2DA showing distinct modulating effects as compared to the other two FAs. Furthermore, we found that these three FAs regulated several proteins involved in MAPK and NF-κB signaling pathways. Taken together, these findings provide additional references for using RJ against inflammatory diseases.

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Section: Discussionmentioning

confidence: 49%

“…Previous studies have reported that 10-H2DA inhibits lipopolysaccharide- (LPS-) induced IL-6 production in a dose-dependent manner [30] and 10-H2DA inhibits LPS and IFN- β induced NO production via inhibition of NF- κ B [31]. Additionally, 10-HDAA could also inhibit LPS-induced NO production by inhibiting the translation of IRF-1 [32].…”

Section: Introductionmentioning

confidence: 99%

In VitroAnti-Inflammatory Effects of Three Fatty Acids from Royal Jelly

Chen

Wang

Zhang

et al. 2016

Mediators of Inflammation

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“…38 In line with the present research, Sugiyama et al reported RJ administration to inhibit nitrite oxide production. 39 The results of the present study suggested that RJ administration in both studied doses might have a positive effect on morphine-induced toxicity, as an oxidative stress, in the neurons of the prefrontal cortex; these effects are not dose-dependent concerning RJ.…”

Section: Discussionsupporting

confidence: 44%

Effects of Royal Jelly on the Prefrontal Cortex in a Rat - Morphine Toxicity Model

Jalili

Roshankhah

Mohammadi

et al. 2019

J Apple Biotechnol Rep

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Introduction: Royal jelly (RJ) is a honey bee secretion with numerous medicinal properties and antioxidant activities. Morphine is a major risk factor in the development of functional disorders in several organ systems. This study was designed to evaluate the effects of RJ against morphineinduced damage to the prefrontal cortex of rats. Materials and Methods: In this study, 48 male Wistar rats were randomly assigned into 6 groups: sham group, morphine group, RJ groups (100, and 200 mg/kg), and morphine + RJ groups. Treatments were administered intraperitoneally and orally for 20 days on a daily basis. Ferric reducing/ antioxidant power (FRAP) method was applied to determine the total antioxidant capacity. The number of neurons and, dendritic spines were investigated by Golgi technique, and Griess technique was employed to determine the serum nitrite oxide level. Results: Morphine administration significantly increased the nitrite oxide level and total antioxidant capacity, and reduced neuronal dendritic spines and neurons compared to the sham group (P < 0.05). In all RJ and Morphine + RJ groups, the number of neurons and neuronal dendritic spines were elevated significantly, while nitrite oxide level and total antioxidant capacity were reduced compared to the morphine group (P < 0.05). Conclusions: RJ administration protected animals against oxidative stress and nitrite oxide. It also improves some prefrontal cortex parameters including number of neurons and dendritic spines because of the morphine.

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“…Various immunomodulatory activities have been reported for 10-HDA, including reduced T cell proliferation, inhibition of interleukin-12 production by spleen dendritic cells, and block of LPS- and IFN-β-induced NO production in macrophages (Gasic et al, 2007; Sugiyama et al, 2013). In another study, a biphasic behavior of 10-HDA on human monocyte-derived dendritic cells has been found, resulting in Th1 response stimulation and Th2 downregulation at 50 μM, and repression of both Th1 and Th2 at 500 μM (Mihajlovic et al, 2013).…”

Section: Royal Jellymentioning

confidence: 99%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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Honeybees produce honey, royal jelly, propolis, bee venom, bee pollen, and beeswax, which potentially benefit to humans due to the bioactives in them. Clinical standardization of these products is hindered by chemical variability depending on honeybee and botanical sources, but different molecules have been isolated and pharmacologically characterized. Major honey bioactives include phenolics, methylglyoxal, royal jelly proteins (MRJPs), and oligosaccharides. In royal jelly there are antimicrobial jelleins and royalisin peptides, MRJPs, and hydroxy-decenoic acid derivatives, notably 10-hydroxy-2-decenoic acid (10-HDA), with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, and anti-aging activities. Propolis contains caffeic acid phenethyl ester and artepillin C, specific of Brazilian propolis, with antiviral, immunomodulatory, anti-inflammatory and anticancer effects. Bee venom consists of toxic peptides like pain-inducing melittin, SK channel blocking apamin, and allergenic phospholipase A2. Bee pollen is vitaminic, contains antioxidant and anti-inflammatory plant phenolics, as well as antiatherosclerotic, antidiabetic, and hypoglycemic flavonoids, unsaturated fatty acids, and sterols. Beeswax is widely used in cosmetics and makeup. Given the importance of drug discovery from natural sources, this review is aimed at providing an exhaustive screening of the bioactive compounds detected in honeybee products and of their curative or adverse biological effects.

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Inhibitory Mechanism of 10-Hydroxy-trans-2-decenoic Acid (Royal Jelly Acid) Against Lipopolysaccharide- and Interferon-β-Induced Nitric Oxide Production

Cited by 41 publications

References 24 publications

In VitroAnti-Inflammatory Effects of Three Fatty Acids from Royal Jelly

In VitroAnti-Inflammatory Effects of Three Fatty Acids from Royal Jelly

Effects of Royal Jelly on the Prefrontal Cortex in a Rat - Morphine Toxicity Model

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

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