Inhibitory effects of zinc on magnesium balance and magnesium absorption in man.

Spencer, Herta; Norris, C; Williams, David N.

doi:10.1080/07315724.1994.10718438

Cited by 37 publications

(20 citation statements)

References 37 publications

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“…In a prospective study of 4035 men, a combined low Zn and high Mg intake was associated with decreased all-cause mortality risk (25) . In a supplementation trial, a relatively high Zn intake (142 mg/d) was found to inhibit Mg balance and absorption in men (26) . Thus, it is unclear whether the change in Mg metabolism in the postmenopausal women in the metabolic unit study (16) was the result of the low Zn increasing Mg retention, the high Zn intake decreasing Mg balance, or both Zn deficiency and excess playing a role in changing the Mg balance.…”

Section: Discussionmentioning

confidence: 99%

Reported zinc, but not copper, intakes influence whole-body bone density, mineral content and T score responses to zinc and copper supplementation in healthy postmenopausal women

et al. 2011

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A supplementation trial starting with 224 postmenopausal women provided with adequate vitamin D and Ca was conducted to determine whether increased Cu and Zn intakes would reduce the risk for bone loss. Healthy women aged 51-80 years were recruited for a doubleblind, placebo-controlled study. Women with similar femoral neck T scores and BMI were randomly assigned to two groups of 112 each that were supplemented daily for 2 years with 600 mg Ca plus maize starch placebo or 600 mg Ca plus 2 mg Cu and 12 mg Zn. Whole-body bone mineral contents, densities and T scores were determined biannually by dual-energy X-ray absorptiometry, and 5 d food diaries were obtained annually. Repeated-measures ANCOVA showed that bone mineral contents, densities and T scores decreased from baseline values to year 2. A priori contrasts between baseline and year 2 indicated that the greatest decreases occurred with Cu and Zn supplementation. Osteoporosis is a worldwide health problem that results in fractures (most often at the hip, spine and wrist). In countries such as the USA, one of every two women over the age of 50 years will have an osteoporosis-related fracture in their lifetime. It is generally agreed that adequate Ca and vitamin D are significant nutritional concerns for bone growth and maintenance and thus for the incidence of osteoporosis. Limited evidence exists that indicates other minerals, including Cu and Zn, also may be of nutritional concern for bone health. Strause et al.(1) supplemented postmenopausal women (average age 66 years) daily with 1·0 g Ca, a cocktail containing 15 mg Zn, 5 mg Mn and 2·5 mg Cu, a combination of the Ca and trace element cocktail, or a placebo for 2 years. Spinal (L2-L4 vertebrae) bone density loss was a substantial 3·53 % in the eighteen subjects given the placebo, 1·25 % in the thirteen subjects given only Ca and 1·89 % in the fourteen subjects given only the trace element cocktail; these changes were not significantly different from each other. In contrast, the fourteen subjects given the Ca plus trace elements had a bone mineral density gain of 1·48 %, which was significantly different from the placebo group. In another supplementation trial, women aged 45-56 years were given daily a placebo or 2·5 mg Cu for 2 years (2) . The Cu supplementation essentially prevented vertebral trabecular bone mineral density loss (2 0·46 %) while the placebo group lost a significant 2·65 %.Other studies showing that Cu is needed for bone health include those showing that preterm infants provided Cudeficient enteral nutrition exhibited osteoporotic-like bone and increased fractures (3,4) , and that plasma Cu concentration was positively correlated with lumbar spine bone mineral density (5) . In rats, Cu deprivation decreased mechanical strength and changed the organic and inorganic composition of femurs (6,7) . In addition to Strause et al. Abbreviations: DXA, dual-energy X-ray absorptiometry; EAR, estimated average requirement.

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Section: Discussionmentioning

confidence: 99%

Reported zinc, but not copper, intakes influence whole-body bone density, mineral content and T score responses to zinc and copper supplementation in healthy postmenopausal women

et al. 2011

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“…Notwithstanding these crucial functions however, zinc toxicity has been reported to impair immune function; inhibit the absorption of copper, calcium, iron and magnesium and promote folate deficiency (Fosmire, 1990;Sandstead, 1995;Dawson et al, 1990;Spencer et al, 1994;Bennett et al, 1997). Razak (2006) reported that zinc enters the milieu in a number of ways both natural and artificial through human activities such as mining, burning of coal, steel production and the burning of waste.…”

Section: Introductionmentioning

confidence: 99%

Contaminants in local alcoholic beverages: zinc and manganese contamination

Gazuwa¹,

Daback²,

Ubom³

2009

International Journal of Biological and Chemical Sciences

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The extent of leaching of zinc (Zn) and manganese (Mn) from the vessels used during the preparation of two local alcoholic drinks, Pito and Burukutu has been assessed. Leaching of these metals during the four phases of fermentation was monitored by determining the levels of the metals in each phase using atomic absorption spectrophotometric technique; in each complete fermentation protocol, metallic or clay container was used. Contamination appeared to be due to the fermentation process, container used or a combination of the two. Comparatively, there was increase in the levels of these metals from the initial to the final phase of fermentation for both types of vessels; in each case, appropriate controls were used. Compared to control values, the average increase in the level of zinc in Burukutu and Pito for metallic and clay containers is 343%; 325% and 295%; 252% respectively; whereas for manganese the increases are 815%; 1438% and 1292%; 1150% in that order. The differences in the levels of these metals among the phases in each of the drinks were significant (p<0.05).

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“…Magnesium + zinc B High doses of zinc appear to decrease magnesium absorption and magnesium balance in healthy adult men (57 of these factors could explain why we found only a low incidence of herbal and homeopathic remedies. Additionally, the composition of some multivitamins was unknown; therefore, it was not possible to evaluate the potential interactions for these products.…”

Section: Study Limitationsmentioning

confidence: 83%

The use of natural health products by paediatric patients in respite care

Beringer

Vaillancourt²,

Villarreal³

et al. 2015

Paediatrics &Amp; Child Health

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Inhibitory effects of zinc on magnesium balance and magnesium absorption in man.

Abstract: Zn supplements of 142 mg/day decreased Mg absorption and the Mg balance significantly during all Ca intakes for the three groups combined.

Cited by 37 publications

References 37 publications

Reported zinc, but not copper, intakes influence whole-body bone density, mineral content and T score responses to zinc and copper supplementation in healthy postmenopausal women

Reported zinc, but not copper, intakes influence whole-body bone density, mineral content and T score responses to zinc and copper supplementation in healthy postmenopausal women

Contaminants in local alcoholic beverages: zinc and manganese contamination

The use of natural health products by paediatric patients in respite care

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