Inhibitory Effects of Zerumbone on MCP-1-Induced THP-1 Migration

Background: A natural sesquiterpene Zerumbone (ZER) is abundant in rhizomes of Zingiber zerumbet (L) Smith, well-known for its beneficial effects. Very few reported studies of Zerumbone (ZER) as well as its bioactive compounds focusing on its neuromodulatory activities based on it functional neuro-anatomy. Objective: The aim of this study was to investigate the neuroanatomical functional site of the zerumbone in rat spinal motor and sensory neurons by means of c-Fos immunohistochemistry. Results: Our present study demonstrated that i.p., administration of zerumbone (100 mg/kg) significantly (p<0.01) increase in the number of c-Fos immunoreactive neurons in the dorsal and ventral nuclei of the rats. Conclusion: The result of the present study strongly indicates that zerumbone has neuromodulatory effects on sensory and motor neurons. To the best of our knowledge, it is the first report which indicates that zerumbone might play crucial roles in motor and sensory neuromodulation. Our findings warrant further study to reveal the underlying molecular mechanisms of zerumbone induced sensory and motor neuromodulation. We suggest the c-Fos immunohistochemical functional mapping of zerumbone in central nervous system of model animals to reveal its therapeutics potential and mechanisms.

show abstract

“…Previous study reported that zerumbone increased cAMP levels (Kim et al, 2018). cAMP is one of the most common and universal second messengers.…”

Section: Discussionmentioning

confidence: 94%

Zerumbone Neuro-modulates Spinal Motor and Sensory Neurons of Rats: a c-Fos study

Kazi¹,

Samshudin²,

Sabirin³

et al. 2023

Compend. Oral Sci.

View full text Add to dashboard Cite

show abstract

A promising effect of zerumbone with improved anti-tumor-promoting inflammation activity of miR-34a in colorectal cancer cell lines

et al. 2021

View full text Add to dashboard Cite

Effects of 2-methoxy-1,4-naphthoquinone (MQ) on MCP-1 Induced THP-1 Migration

Kim

Park

Hong

et al. 2019

Korean J Clin Lab Sci.

View full text Add to dashboard Cite

This study examined the effects of 2-methoxy-1,4-naphthoquinone (MQ) on the monocyte chemoattractant protein-1 (MCP-1)-induced migration of monocytes, which is an important phenomenon for the body defense and immune response. MQ is a major component extracted from Impatiens balsamina leaves, which have been used for many years in Asian medicine for the treatment of a range of diseases and pain. The cytotoxicity of MQ began to appear at a concentration of 10 M, and approximately 50% cytotoxicity was confirmed at 100 M. The MCP-1 induced migration of the THP-1 monocyte cell line increased after MQ treatment in a dose dependent manner and the largest increase was observed at 0.1 M. The level of cAMP expression decreased after a treatment with 0.1 M MQ. The phosphorylation of extracellular signal-regulated kinases 1/2 (Erk1/2), a key signaling protein involved in the signaling pathway of CC motif chemokine receptor 2 (CCR2), a receptor for MCP-1, was increased by the simultaneous treatment of 0.1 M MQ. These results show that MQ increases the MCP-1-induced migration of THP-1, decreases the level of cAMP expression, and increases the level of Erk1/2 phosphorylation.

show abstract

Inhibitory Effects of Zerumbone on MCP-1-Induced THP-1 Migration

Cited by 4 publications

References 18 publications

Zerumbone Neuro-modulates Spinal Motor and Sensory Neurons of Rats: a c-Fos study

Zerumbone Neuro-modulates Spinal Motor and Sensory Neurons of Rats: a c-Fos study

A promising effect of zerumbone with improved anti-tumor-promoting inflammation activity of miR-34a in colorectal cancer cell lines

Effects of 2-methoxy-1,4-naphthoquinone (MQ) on MCP-1 Induced THP-1 Migration

Contact Info

Product

Resources

About