Inhibitory effects of xanthohumol from hops (<i>Humulus lupulus</i> L.) on human hepatocellular carcinoma cell lines

Ho, Yi-Chien; Liu, Chi-Hsien; Chen, Chien-Nan; Duan, Kow‐Jen; Lin, Ming-Tse

doi:10.1002/ptr.2481

Cited by 33 publications

(27 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to our results on normal and cancer brain cells, Ho et al . () found that a normal hepatocyte cell line was less sensitive to XN than two hepatocellular carcinoma cell lines.…”

Section: Resultsmentioning

confidence: 99%

Xanthohumol Induces Different Cytotoxicity and Apoptotic Pathways in Malignant and Normal Astrocytes

Zajc

Filipič

Lah

2012

Phytotherapy Research

View full text Add to dashboard Cite

Cytotoxicity and the mechanisms of cell death induced by xanthohumol (XN) were compared in normal and cancerous human cells as the differences may be relevant for the potential use of XN in cancer therapy. The cancer cells seemed to be more susceptible to the cytotoxicity of XN than normal cells, but a significant difference was observed only in astrocytic cells. XN induced a higher rate of apoptosis in glioblastoma cells than in normal astrocytes, which was associated with activation of p53 and an elevated Bax/Bcl-2 ratio in glioblastoma cells, indicating an intrinsic caspase-dependent apoptotic pathway. In contrast, a reduced Bax/Bcl-2 ratio was observed in normal human astrocytes. This was also associated with higher expression of the cell cycle inhibitor, p21, in glioblastoma cells than in normal astrocytes. In addition, at a lower, non-cytotoxic concentration, XN partially inhibited the invasiveness of glioblastoma cells. Due to the selective sensitivity of astrocytic cells to XN, this compound should be studied further as a candidate for adjuvant therapy in the treatment of glioma.

show abstract

“…Similar to our results on normal and cancer brain cells, Ho et al . () found that a normal hepatocyte cell line was less sensitive to XN than two hepatocellular carcinoma cell lines.…”

Section: Resultsmentioning

confidence: 99%

Xanthohumol Induces Different Cytotoxicity and Apoptotic Pathways in Malignant and Normal Astrocytes

Zajc

Filipič

Lah

2012

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Moreover, the preventive effect of flavonoids, quercetin or Acacia nilotica bark extract (ANBE) via oxidant/antioxidant activity was demonstrated on hepatic cancer in rats [83-85]. Recently several other molecules with antioxidative properties were evaluated (for example, Siraitia grosvenorii extract, black tea polyphenols, xanthohumol from hops (Humulus lupulus L.)) [86-88]. Also, butyric acid (BA) being a member of histone deacetylase inhibitors (HDAI) has been proposed as chemiopreventive agent.…”

Section: Antioxidants Role In Hcc Chemopreventionmentioning

confidence: 99%

Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment

Castello¹,

Costantini²,

Scala

2010

J Transl Med

View full text Add to dashboard Cite

Epidemiological, preclinical and clinical studies demonstrated that chronic inflammation induced by hepatitis C virus (HCV) is crucial in hepatocellular carcinogenesis. The interaction between hepatocytes and microenvironment regards virus, inflammatory and immunocompetent cells, chemo- and cyto-kines, reactive oxygen species (ROS) and nitric oxide (NO), generating cell transformation. We suggest hepatocarcinoma (HCC) as a model in which the targeting of microenvironment determine neoplastic transformation. The present review focuses on: the role of inflammation in carcinogenesis, the clinical impact of HCC and the inadequacy of the actual therapy, the chemoprevention targeting the microenvironment.

show abstract

“…Thus, stimulation of prostate cancer cells with 20 μM XN resulted in an approximately halved viability (4), and XN concentration of 100 μM induced 100% cell death in breast cancer cells (1). Recently, Ho et al reported that XN induced apoptosis in two HCC cell lines in vitro (29). However, in this study considerably higher XN concentrations (>200 μM) were required to induce death of all HCC cells.…”

Section: Discussionmentioning

confidence: 69%

“…Yang et al described loss of viability in approximately 90% of 3T3-L1 cells, a murine adipocyte cell line, after 24 h treatment with 75 μM XN (39). In the (nonmalignant) murine hepatoma cell line AML12 the maximal applied concentration of 225 μM XN (24 h) induced toxicity in approximately 50% of the cells as reported by Ho et al (29). However, to the best of our knowledge, no data have been reported concerning the effect of XN on primary human cells.…”

Section: Discussionmentioning

confidence: 76%

Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells

Dorn

Weiss²,

Heilmann³

et al. 2009

Int J Oncol

View full text Add to dashboard Cite

Abstract. Xanthohumol, the major prenylated chalcone found in hops, is well known to exert anti-cancer effects, but information regarding the impact on hepatocellular carcinoma (HCC) cells and potential adverse effects on non-tumorous hepatocytes is limited. Here, we show that xanthohumol at a concentration of 25 μM induced apoptosis in two HCC cell lines (HepG2 and Huh7). Furthermore, xanthohumol repressed proliferation and migration, as well as TNF induced NF-κB activity and interleukin-8 expression in both cell lines at even lower concentrations. In contrast, xanthohumol concentrations up to 100 μM did not affect viability of primary human hepatocytes in vitro. In summary, our data showed that xanthohumol can ameliorate different pro-tumorigenic mechanisms known to promote HCC progression, indicating its potential as promising therapeutic agent that selectively affects cancer cells.

show abstract

Inhibitory effects of xanthohumol from hops (Humulus lupulus L.) on human hepatocellular carcinoma cell lines

Cited by 33 publications

References 19 publications

Xanthohumol Induces Different Cytotoxicity and Apoptotic Pathways in Malignant and Normal Astrocytes

Xanthohumol Induces Different Cytotoxicity and Apoptotic Pathways in Malignant and Normal Astrocytes

Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment

Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells

Contact Info

Product

Resources

About