Inhibitory Effects of Vitamin E on Collagen Synthesis and Wound Repair

Ehrlich, H. Paul; Tarver, Harold; Hunt, Thomas K.

doi:10.1097/00000658-197202000-00013

Cited by 135 publications

(32 citation statements)

References 10 publications

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“…Topical formulations of vitamin E have been promoted to help wound healing, presumably because they inhibit collagen synthesis and reduce both fibroblast proliferation and inflammation. 31,52 Erhan et al 53 suggest that both vitamin E and selenium promote wound healing activity by increasing the blood flow in the wound region. New evidences from the studies on diabetic mouse models point to an involvement of oxidative stress in diabetic wound healing and significantly improved wound healing by topical vitamin E. 54,55 Another finding showed vitamin E or α-tocopherol supplementation reduced the levels of lipid peroxides in the wound tissue of diabetic rats, and the wound healing process was enhanced, in particular in the Vitamin E treated animals.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Hamidi

Naeini

Oryan

et al. 2017

tjps

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ÖZAmaç: Bu çalışma, sıçanlarda oluşturulan deneysel yara modelinde Pistacia atlantica yağı ile hazırlanmış jel formülasyonunun, enzimatik antioksidanlar üzerindeki etkisini araştırmak amacıyla yapılmıştır. Gereç ve Yöntemler: Genel anestezi altına alınan hayvanlarda, aseptik koşullarda, insizyon yapmak suretiyle kare şeklinde yaralar (2x2 cm) oluşturulmuştur. Daha sonra, hayvanlar rasgele dört gruba ayrılmıştır (I-tedavi edilmemiş kontrol grubu, II-haricen uygulanan baz jel grubu, IIIharicen %5 jel uygulanan grup, IV-haricen %10 jel uygulanan grup). Bulgular: Sonuçlar, Pistacia atlantica yağı ile hazırlanmış jel formülasyonunun haricen uygulanmasının, kontrol ve baz jel gruplarına kıyasla, bütünlüğü bozulmamış stratum bazalisi, olgun granülasyon dokusunu, kıl folikülleri ve ter bezleri ile reepitelizasyonu arttırdığını göstermektedir. Yara oluşumundan 21 gün sonra, %10 yağlı jel ile tedavi edilen hayvanların dokularındaki gerilme kuvveti, kopma gerilimi ve bükülme direnci, kontrol ve baz jel grubu ile karşılaştırıldığında önemli ölçüde artmıştır. Aynı evredeki kontrol ve baz jel ile muamele edilen gruplara kıyasla, kollajen liflerin daha organize bir düzenlenme ve dokunun daha düzgün bir iyileşme gösterdiği belirlenmiştir. Sonuç: Pistacia atlantica yağ jelinin haricen uygulanmasının, sıçanlarda oluşturulan deneysel yaralar üzerinde morfolojik, biyokimyasal ve biyomekanik yönden düzeltici rol oynadığı ortaya koyulmuştur. Anahtar kelimeler: Pistacia atlantica, yara iyileşmesi, histopatoloji, biomekanik, deri Objectives: This study has been undertaken to investigate the antioxidant activity of the gel formulation from Pistacia atlantica oil extraction on enzymatic antioxidants in experimental wound created in rats. Materials and Methods: Under anesthesia, a square-shaped skin defect (2x2 cm) was created aseptically by surgical incision. Then, animals were randomly allocated to four groups (I-untreated controls, II-topically treated with base gel, III-topically treated with 5% gel, IV-topically treated with 10% gel). Results:The results suggest that topical application of Pistacia atlantica oil gels improved reepithelialization with continuous stratum basalis and a mature granulation tissue and adnexa (hair follicles and sweat gland) compared with control and base gel groups. Treatment with 10% oil gel significantly enhanced the tensile strength, ultimate stress, yield strength and stiffness in this group compared with the control and base gel groups at 21 days post injury. The collagen fibers showed a more organized pattern and the tissue alignment was greater as compared to the control and base gel-treated groups at the same stage. Conclusion:The results suggest that topical application of Pistacia atlantica oil gel improved the morphological, biochemical and biomechanical properties of experimentally-induced wound defects in rats.

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Section: Discussionmentioning

confidence: 99%

“…In fact, studies report some adverse effects related to its use. 74 Some reports indicate that vitamin E may impair collagen synthesis and wound healing in animals 52,75 whereas other authors report enhanced healing in irradiated rat skin and patients with post thrombotic leg ulcers.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Hamidi

Naeini

Oryan

et al. 2017

tjps

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“…In 1971, Ehrlich et al [31] published a paper in which they described the effect of vitamin E on collagen synthesis. They found that vitamin E inhibited wound healing due to the accumulation of collagen.…”

Section: Nutrition and Wound Healingmentioning

confidence: 99%

A Short Overview on Nutrition, Wound Healing and Medical Textiles

Uzun

Bach

Jockenhoevel

et al. 2015

Marmara Fen Bil Dergisi

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The objective of this paper is to determine wounds, wound healing and the effect of nutrition on wound healing. In recent times, the developments in cellular and molecular biology have greatly expanded and enhanced the current understanding of the biological processes involved in wound healing and tissue regeneration. A remarkable progress has been achieved and an ever-growing number of wound care products have been designed and developed to incorporate the latest understanding of cellular and molecular level phenomena involved in the dynamic and complex process of wound healing, including blood coagulation, inflammation, fibroplasias, collagen deposition and wound contraction. The primary goals of innovations are aimed at alleviating patient suffering; shortening wound healing time periods, and resolving chronic wound healing clinical problems. The investigation and innovation of novel wound dressing materials and methods are an important part of the fast growing biomaterials industry worldwide.

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“…Immune cells such as lymphocytes, polymorphonuclear leukocytes and lymphoid tissues carry out many functions which generate free radicals. Ineffective elimination of free radicals can result in tissue injury , delayed healing, and increased susceptibility to infectious disease (23,74). To control oxidation, immune cells contain concentrated amounts of antioxidants (59).…”

Section: Antioxidant Vitamins and Mineralsmentioning

confidence: 99%