Inhibitory effects of trehalose on fibroblast proliferation and implications for ocular surgery

Connexin43 Modulation Inhibits Scarring in a Rabbit Eye Glaucoma Trabeculectomy Model

“…The main disparity with our results compared to other approaches used previously though was in the assessment of clinical parameters where better success has been reported with bleb presence and prolonged bleb survival in treated animals [39,41,43]. A possible explanation is that our surgical technique involved only one injection of Cx43 AsODN at the time of surgery.…”

“…N (Cx43 AsODN, 21 days)=9; N (BSS, 21 days)=9; N (Pluronic gel, 21 days)=2. [40], trehalose [41] and ilomastat [38,42]. 5-FU seems to have little scar inhibitory effects when compared to bevacizumab [39] and CAT-152 [40].…”

“…A possible explanation is that our surgical technique involved only one injection of Cx43 AsODN at the time of surgery. Other groups often used multiple injections during the postoperative course [38,41,47,48]. For example, a study on the effects of the matrix metalloproteinase inhibitor ilomastat involved daily subconjunctival injections of ilomastat for the first 9 days, twice weekly injections for the following 2 weeks and once weekly injections for the next 2 weeks [38,42].…”

Anhydrobiosis: An Unsolved Problem with Applications in Human Welfare

“…In more recent studies, the same group showed that administration of the trehalose solutions maintains that smoothness (Izawa et al 2006). Some recent suggestions concerning how this might work include inhibition of fibroblast differentiation by trehalose (thus, inhibiting formation of scar tissue; Takeuchi et al 2010), direct protection of the corneal epithelium from desiccation damage (Hovakimyan et al 2012), and inhibition of cytokine mediated inflammation in the cornea (Cejkova et al 2011). It is unclear how the sugar imparts any of these effects, but it continues to be of interest in ophthalmic applications (e.g.…”

Topical Silver Nanoparticles Result in Improved Bleb Function by Increasing Filtration and Reducing Fibrosis in a Rabbit Model of Filtration Surgery

“…Many have been tried in both animals and humans with variable degrees of success. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] Elemental silver has long been used as a medical agent for its anti-infective properties, and has been used in ophthalmology in silver nitrate form as an agent to prevent ophthalmia neonatorum. More recently, silver nanoparticles (AgNPs, diameter < 100 nm) that retain broad spectrum antibacterial activity have been developed.…”