Inhibitory effects of Thyme oils on growth and aflatoxin production by Aspergillus parasiticus

Rasooli, Iraj; Razzaghi-Abyaneh, Mehdi

doi:10.1016/j.foodcont.2003.07.002

Cited by 200 publications

(133 citation statements)

References 16 publications

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“…De Billeberk et al (2001) and Rasooli and Abyaneh (2004) stated that these kinds of morphological changes in moulds caused by exposure to essential oils suggest that the mode of antifungal activity could include an attack on the cell wall and retraction of the cytoplasm in the hyphae ultimately resulting in death of mycelium. Moreover, Carmo et al (2008) reported that these changes could also be related to the interference of the essential oil components in enzymatic reactions of cell wall synthesis affecting the fungal growth and morphogenesis.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Origanum essential oils for inhibition of potentially pathogenic fungi

Souza

Lima

Guedes

et al. 2010

Braz. J. Pharm. Sci.

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Section: Resultsmentioning

confidence: 99%

Efficacy of Origanum essential oils for inhibition of potentially pathogenic fungi

Souza

Lima

Guedes

et al. 2010

Braz. J. Pharm. Sci.

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“…A strong inhibitory activity of the crude extract may be related to the high content of alkaloids (harmine, harmaline and tetrahydroharmine) and phenolic compounds. Phenolic compounds might alter fungal cell permeability and thus permit loss of macromolecules (Rasooli 2004). The exact mode of action of phenols has not been determined, but they may inactivate essential enzymes, react with cell membrane proteins or even disrupt function of the genetic material (Telezhenetskaya and Dyakonov 2004).…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Activity of Selected Plant Crude Extracts and Fractions Against Penicillium Italicum

Kanan¹,

Al-Najar²

2009

Journal of Plant Protection Research

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Abstract:The objective of this study is to evaluate (in vitro and in vivo) seven plant extracts and their liquid fractions against four Penicillium italicum isolates. The in vitro study revealed that a concentration 520 µg/ml of crude extract of sticky fleabane leaves or cinnamon bark generated maximum percentage inhibition of 54% and 43%, respectively, against tested fungal isolates. A concentration of 130 µg /ml from each extract (except harmal and garlic where, 390 µg/ml were required) caused complete inhibition of fungal growth of isolates Pi.1 and Pi.3 infecting orange fruit. A concentration of 130 µg/ml of nightshade fruit, fenugreek or sticky fleabane extract inhibited completely the growth of isolates Pi.3 and Pi.5 infecting lemon fruits, whereas a concentration of 390 µg/ml was required to inhibit the growth of isolate Pi.1. Methanolic fractions of cinnamon, garlic or sticky fleabane completely inhibited the growth of fungal isolates. The IC 50 values for these fractions were found to be in the range of: 11.2-24; 30.25-31.50; 25.0-36.0 µg/ml, respectively.A concentration 20 µg/ml of cinnamon hexane fraction inhibited the growth of the fungal isolates, with IC 50 values of 13, 13.75, 14 and 13 µg/ml, respectively, obtained against isolates Pi.1, Pi.3, Pi.5 and Pi.6. The nightshade hexane fraction completely inhibited the growth of isolates Pi.1 and Pi.3 with IC 50 values of 80 and 37.5 µg/ml, respectively. Cinnamon aqueous fraction completely inhibited the growth of isolates Pi.1 and Pi.5 (IC 50 were 61.25 and 58.5 µg/ml, respectively).

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“…The mycelium samples were dried at 60 uC for 6 h, then at 40 uC overnight, and weighed. Percentage growth inhibition on the basis of dry weight was calculated as: [(control weight2sample weight)/control weight]6100 (Rasooli & Abyaneh, 2004). All experiments were conducted in triplicate.…”

Section: Methodsmentioning

confidence: 99%

In vitro antifungal activity and mechanism of essential oil from fennel (Foeniculum vulgare L.) on dermatophyte species

Zeng

Chen

Liang

2015

Journal of Medical Microbiology

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Fennel seed essential oil (FSEO) is a plant-derived natural therapeutic against dermatophytes. In this study, the antifungal effects of FSEO were investigated from varied aspects, such as MIC and minimum fungicidal concentration, mycelia growth, spore germination and biomass. The results indicated that FSEO had potent antifungal activities on Trichophyton rubrum ATCC 40051, Trichophyton tonsurans 10-0400, Microsporum gypseum 44693-1 and Trichophyton mentagrophytes 10-0060, which is better than the commonly used antifungal agents fluconazole and amphotericin B. Flow cytometry and transmission electron microscopy experiments suggested that the antifungal mechanism of FSEO was to damage the plasma membrane and intracellular organelles. Further study revealed that it could also inhibit the mitochondrial enzyme activities, such as succinate dehydrogenase, malate dehydrogenase and ATPase. With better antifungal activity than the commonly used antifungal agents and less possibility of inducing drug resistance, FSEO could be used as a potential antidermatophytic agent.

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Inhibitory effects of Thyme oils on growth and aflatoxin production by Aspergillus parasiticus

Cited by 200 publications

References 16 publications

Efficacy of Origanum essential oils for inhibition of potentially pathogenic fungi

Efficacy of Origanum essential oils for inhibition of potentially pathogenic fungi

In Vitro and In Vivo Activity of Selected Plant Crude Extracts and Fractions Against Penicillium Italicum

In vitro antifungal activity and mechanism of essential oil from fennel (Foeniculum vulgare L.) on dermatophyte species

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