Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets

Kundu, Joydeb Kumar; Mossanda, Kensese S.; Na, Hye-Kyung; Surh, Young‐Joon

doi:10.1016/j.canlet.2004.07.029

Cited by 73 publications

(48 citation statements)

References 42 publications

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“…42 An effect in vitro does not imply an effect in vivo, for example, because the responsible components may undergo mammalian metabolism modifying their activity and/or may not be bioavailable. A plant extract indicating antimutagenicity is not necessarily an anticarcinogen; however, it is a strong indication of possible anticarcinogenic properties that should stimulate further investigation.…”

Section: Discussionmentioning

confidence: 99%

Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Lira

Santos

Sannomiya

et al. 2008

Journal of Medicinal Food

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Byrsonima basiloba A. Juss. species is a native arboreal type from the Brazilian "cerrado" (tropical American savanna), and the local population uses it to treat diseases, such as diarrhea and gastric ulcer. It belongs to the Malpighiaceae family, and it is commonly known as "murici." Considering the popular use of B. basiloba derivatives and the lack of pharmacological potential studies regarding this vegetal species, the mutagenic and antimutagenic effect of methanol (MeOH) and chloroform extracts were evaluated by the Ames test, using strains TA97a, TA98, TA100, and TA102 of Salmonella typhimurium. No mutagenic activity was observed in any of the extracts. To evaluate the antimutagenic potential, direct and indirect mutagenic agents were used: 4 nitro-o-phenylenediamine, sodium azide, mitomycin C, aflatoxin B 1 , benzo[a]pyrene, and hydrogen peroxide. Both the extracts evaluated showed antimutagenic activity, but the highest value of inhibition level (89%) was obtained with the MeOH extract and strain TA100 in the presence of aflatoxin B 1 . Phytochemical analysis of the extracts revealed the presence of n-alkanes, lupeol, ursolic and oleanolic acid, (ϩ)-catechin, quercetin-3-O-␣-L-arabinopyranoside, gallic acid, methyl gallate, amentoflavone, quercetin, quercetin-3-O-(2Љ-O-galloyl)-␤-D-galactopyranoside, and quercetin-3-O-(2Љ-O-galloyl)-␣-L-arabinopyranoside.

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Section: Discussionmentioning

confidence: 99%

Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Lira

Santos

Sannomiya

et al. 2008

Journal of Medicinal Food

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“…Sutherlandia frutescens Antiinflammatory because it inhibits COX-2 and through activation of activator protein-1 (AP-1) (Kundu et al, 2005) Uncaria tomentosa Antiinflammatory achieved by a TNFalpha and PGE2 production inhibition (Piscoya et al, 2001) Immunostimulant because it stimulates macrophage phagocytosis (Groom et al, 2007) Panax ginseng and Antiinflammatory: It inhibits iNOS and COX-2 protein expression, and activates the transcription factor, NF-kappaB (Park et al, 2004).…”

Section: Alsomentioning

confidence: 99%

Clinical outcomes of diabetic foot management with Circulat

Olalde¹,

Magarici²,

Amendola³

et al. 2008

Phytotherapy Research

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Major and minor lower-extremity amputation is a common complication among diabetics. Various sources indicate diabetic foot ulcer prevalence at between 2.2% and 15% in diabetics. This study evaluates the efficacy and tolerance of a standardized plant extract combination, Circulat, developed for the prevention and treatment of severe manifestations of type 2 diabetes, such as necrotic damage of the foot. Thus, a retrospective cohort study was carried out in 174 patients treated with Circulat with diabetic foot grades D1-D3, according to The University of Texas Wound Classification System, in 50 medical centers, from 2004 to 2007. Circulat obtained 50.57% complete cure of diabetic foot, significant improvement in 37.9% and prevented amputation in 88.5% of the study's total population. The treatment was well tolerated. Four patients (2.3%) had slight gastrointestinal unrest which did not warrant suspension of treatment.

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“…Devil's claw, Harpagophytum procumbens DC (Pedaliaceae) used in South Africa for the management of pain and inflammation is an example of medicinal plant whose anti-inflammatory activities is based on reported inhibition of COX (Kundu et al, 2005). Anti-inflammatory effects of seven lignans and one dihydrochalcone isolated from the leaves of two Lauraceae species (Pleurothyrium cinereum and Ocotea macrophylla), were found to be potent inhibitors of COX-2/5-LOX (Coy-Barrera and Cuca-Suarez, 2011).…”

Section: Inhibitors Of Cyclooxygenases (Cox)mentioning

confidence: 99%

Anti-inflammatory medicinal plants and the molecular mechanisms underlying their activities

Nworu¹,

Akah²

2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Medicinal plant and plant products have shown tremendous potentials and are used beneficially in the treatment of inflammation and in the management of diseases with significant inflammatory components. Many medicinal plants employed as anti-inflammatory and antiphlogistic remedies lack the gastro-erosive side effects of non-steroidal anti-inflammatory drugs (NSAID) or the plethora of unwanted side effects associated with steroidal anti-inflammatory drugs. In order to harness and optimise the applications of these herbs in inflammatory diseases, there is a need to understand how these herbs produce their anti-inflammatory actions. Materials and Methods: This paper is a review of some anti-inflammatory herbs and their molecular mechanisms of action. A literature search and analysis of published manuscript was employed to x-ray research findings that show how medicinal plants produce anti-inflammatory activities. Results: Many studies have shown that anti-inflammatory activities of herbal extracts and herb-derived compounds are mainly due to their inhibition of arachidonic acid (AA) metabolism, cyclo-oxygenase (COX), lipo-oxygenase (LOX), pro-inflammatory cytokines, inducible nitric oxide, and transcription activation factor (NF-κB). Some anti-inflammatory medicinal herbs are reported to stabilize lysosomal membrane and some cause the uncoupling of oxidative phosphorylation of intracellular signalling molecules. Many have also been shown to possess strong oxygen radical scavenging activities. Conclusion: Most of the mechanisms by which anti-inflammatory medicinal plants act are related and many herbal products have been shown to act through a combination of these molecular pathways.

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Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets

Cited by 73 publications

References 42 publications

Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Clinical outcomes of diabetic foot management with Circulat

Anti-inflammatory medicinal plants and the molecular mechanisms underlying their activities

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