1995
DOI: 10.1111/j.1476-5381.1995.tb13368.x
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Inhibitory effects of SR 58611A on canine colonic motility: evidence for a role of β3‐adrenoceptors

Abstract: 1. In order to clarify whether atypical or beta 3-adrenoceptors can modulate canine colonic motility in vivo, we studied the effects of SR 58611A (a selective agonist for atypical beta-adrenoceptors) alone and after pretreatment with beta-adrenoceptor antagonists on colonic motility in the conscious dog. The gastrocolonic response (postprandial increase in motility) was monitored by means of electrodes and strain-gauge force transducers chronically implanted along the distal colon. In some experiments, heart r… Show more

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Cited by 19 publications
(10 citation statements)
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“…Our human β 3 ‐adrenoceptor immuno‐localization findings and the evidence of others that supports localization of this receptor on the smooth muscle of the rat jejunum, 2 colon, 3 stomach, 14 oesophagus, 20 the guinea pig caecum 21 and the dog colon, 22 suggest species‐common receptor functions for the β 3 ‐adrenoceptor protein in the mammalian gastrointestinal tract. The β 3 ‐adrenoceptor agonist SR58611A has recently been shown to inhibit gastric acid secretion in the cat stomach 23 …”
Section: Discussionsupporting
confidence: 83%
“…Our human β 3 ‐adrenoceptor immuno‐localization findings and the evidence of others that supports localization of this receptor on the smooth muscle of the rat jejunum, 2 colon, 3 stomach, 14 oesophagus, 20 the guinea pig caecum 21 and the dog colon, 22 suggest species‐common receptor functions for the β 3 ‐adrenoceptor protein in the mammalian gastrointestinal tract. The β 3 ‐adrenoceptor agonist SR58611A has recently been shown to inhibit gastric acid secretion in the cat stomach 23 …”
Section: Discussionsupporting
confidence: 83%
“…Evidence suggesting a direct action of the ␤ 3 agonist on the gastrointestinal tract includes the identification of ␤ 3 -adrenergic receptors throughout the gastrointestinal tract (35,36) and the observation that ␤ 3 agonists inhibit in vitro colon contraction bioassays (37). On the other hand, a ␤ 3 agonist slows intestinal motility in mice lacking all ␤ 3 receptors except those in adipose tissue (23).…”
Section: Discussionmentioning
confidence: 99%
“…These studies showed a much larger population of p2-with respect to Pi-adrenoceptors, while Pv-adrenoceptors could not be detected, most probably because of the weak affinity of the ligand used. Thus, when considering p-adrenoceptors from a functional point of view, the guinea pig colon is similar to the rat and dog colon, two species where pi-adrenoceptor agonists can inhibit colonic motility both in vitro [14,40] and in vivo [40,41]. The functional relevance of the inhibitory effect observed with SR 58611A can also be argued by the observation that the compound blocked the occurrence of an orga nized, propulsive motor event such as the peristaltic reflex.…”
Section: Discussionmentioning
confidence: 93%