Inhibitory Effects of Some Steroidal Saponins on Human Spermatozoain vitro

Abstract

Twenty-nine C-27 steroidal saponins were tested for the inhibitory effects on human spermatozoa in vitro by means of a modified Sander-Cramer method. Twelve of them are responsible for this activity. The structure-activity relationship is discussed.

Global and societal implications of the diabetes epidemic

“…La mejor molécula correspondió a ZINC000253529756, identificada con el nombre IUPAC (2S,3R,4R,5R,6S)-2-{[(2R,3R,4S,5R,6R)-4,5-dihidroxi-6-metil-2-[(2R, 4'S, 7'S, 8'R, 9'S, 13'R, 14'R, 16'R)-7', 9', 13'-trimetil-5-metiliden-16'-{[(2R, 3R, 4R, 5R, 6S)-3, 4, 5-trihidroxi-6-metiloxan-2-il]oxi}-5'-oxaspiro[oxan-2, 6'-pentaciclo[10.8.0.0², ⁹.0⁴, ⁸.0¹³, ¹⁸]icosan]-18'eneoxi]oxan-3-il]oxi}-6-metiloxan-3, 4, 5-triol (figura 3-5) puede encontrarse también en la base de datos Zinc.docking.org con otros códigos (ZINC000253529754, ZINC000253529755, ZINC000253529756, ZINC000253529757), moléculas con estructura similar (tipo saponinas) extraídas de plantas de la familia Liliaceae han reportado actividad antimicrobiana, de inhibición sobre la fosfodiesterasa AMPc y espermicida (Wang, Li, Yang, Wang, & Yang, 1996).…”

Tupisteroide A–C, three new polyhydroxylated steroidal constituents from the roots of Tupistra chinensis

“…Steroidal saponin is an important class of chemical composition in natural products, and most of them possess many bioactivities, such as inhibitory effects on human spermatozoa, molluscicidal activities, and cAMP phosphodiesterase in vitro , and in the reduction of blood glucose levels . Tupistra chinensis Bak (kaikoujian in Chinese) belongs to the family Liliaceae (Convallarieae), which is rich in steroidal saponins, and it is mainly distributed in the southwest of China.…”