Inhibitory Effects of Retinoic Acid Receptor Alpha Stimulants on Murine Cataractogenesis through Suppression of Deregulated Calpains

Nishikiori, Nami; Osanai, Makoto; Chiba, Hideki; Kojima, Takashi; Ohguro, Hiroshi; Sawada, Norimasa

doi:10.1167/iovs.06-1222

Cited by 7 publications

(8 citation statements)

References 35 publications

(58 reference statements)

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“…Retinoids suppress the differentiation of preadipocytes to adipocytes [28], and promote alveolar regeneration in mammalian lungs [29]. Other observations suggest several clinical potential applications such as the treatment of diabetic retinopathy [30] and cataract [31]. Animal experiments using non-obese diabetic (NOD) mice suggested that retinoids may be effective to suppress type I diabetes and Schoegren’s syndrome [32].…”

Section: Biological and Pharmacological Activities Of Retinoidsmentioning

confidence: 99%

Towards Retinoid Therapy for Alzheimers Disease

Shudo¹,

Fukasawa²,

Nakagomi³

et al. 2009

CAR

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Alzheimer’s disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and age-related changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD.

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Section: Biological and Pharmacological Activities Of Retinoidsmentioning

confidence: 99%

Towards Retinoid Therapy for Alzheimers Disease

Shudo¹,

Fukasawa²,

Nakagomi³

et al. 2009

CAR

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“…The cut-off levels in mice used to diagnose diabetes were more than 200 mg/dl in blood sugar measured using Gluco-card (ARKRAY, Kyoto, Japan) and positive urinal sugar measured using Rub-stick (Bayer, Leverkusen, Germany). Six weeks after the verification of diabetes, when the blood–retinal barrier breakdown was progressing as previously described (Nishikiori et al 2007a), mice were treated with 1.0 mg/kg ATRA every day (seven mice, 14 eyes) or 3.75 mg/kg Am580 every other day (nine mice, 18 eyes) for 1 week (Nishikiori et al 2007a, 2007b). Control mice (eight mice, 16 eyes) were i.p.…”

Section: Methodsmentioning

confidence: 99%

Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy

Nishikiori

Osanai²,

Chiba³

et al. 2008

OPTH

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PurposeThis study was conducted to investigate whether retinoic acids (RAs) had any effect on apoptosis during the development of diabetic retinopathy.MethodsTo investigate whether RAs had any effect on apoptosis during the development of diabetic retinopathy, we housed 32 C57BL/6 male mice and induced diabetes in 24 by intra peritoneal injections of streptozotocin (STZ; Sigma, St Louis, MO) and treated 16 of the diabetic mice with the RAs, all-trans-retinoic acid (ATRA) (seven mice) and 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido] benzoic acid (Am580) (nine mice). The other eight mice were used as diabetic controls. We then measured apoptosis in the retina by TdT-dUTP terminal nick-end labeling assay.ResultsRAs inhibited the apoptosis of retinal cells in diabetic retinopathy. Many apoptotic cells were observed in retinas of the eight diabetic control mice (mean value and SD: 37.8 ± 6.9), whereas when diabetic mice were treated with RAs, the number of apoptotic cells significantly decreased (mean value and SD: 9.9 ± 6.4 for the seven ATRA-treated diabetic mice and 9.8 ± 5.9 for the nine Am580-treated diabetic mice) (p < 0.05).ConclusionTreatment with RAs decreases apoptosis during the development of diabetic retinopathy.

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“…It was demonstrated that stimulation of RARα decreased Ca2+ influx into the lens and reduced the over activation of calpains. RARα can potentially be used for prevention and treatment of human diabetic cataracts [23]. …”

Section: Nrs and Ocular Diseasesmentioning

confidence: 99%

The association between nuclear receptors and ocular diseases

2017

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Nuclear hormone receptors (NRs) are one of the most abundant transcription factors in the human cells. They regulate expression of genes via interactions with corresponding ligands, co-activators, and co-repressors. These molecular pathways play important roles in the development, cell differentiation, and physiologic and metabolic processes. Increasingly, targeting nuclear receptors is becoming a promising strategy for new drug development. The aim of this review is to discuss the association between nuclear receptors and eye development, and expand their role in various ocular diseases such as keratitis, cataract, glaucoma, uveitis, retinopathy, and ophthalmic tumors. Recent studies in this area are highlighted as well as future research directions and potential clinical applications. Finally, various strategies will be elucidated to inspire more targeted therapies for ocular diseases through the use of nuclear receptors.

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Inhibitory Effects of Retinoic Acid Receptor Alpha Stimulants on Murine Cataractogenesis through Suppression of Deregulated Calpains

Abstract: Results showed that a certain type of RA inhibits Ca(2+) elevation and subsequent overactivation of calpains, suggesting the potential feasibility of calpain-targeting therapies mediated by RA for cataract.

Cited by 7 publications

References 35 publications

Towards Retinoid Therapy for Alzheimers Disease

Towards Retinoid Therapy for Alzheimers Disease

Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy

The association between nuclear receptors and ocular diseases

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