Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication

Choi, Hee Joung; Song, Jeho; Park, Kwi Sung; Kwon, Dur Han

doi:10.1016/j.ejps.2009.03.002

Cited by 182 publications

(123 citation statements)

References 25 publications

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“…Quercetin 3-rhamnoside (Q3R, 24, Figure 5) from Houttuynia cordata possessed strong antiviral activity against influenza A/WS/33 virus as well as oseltamivir [94]. Pre-exposure of the virus to Q3R did not alter the infectivity.…”

Section: Quercetin 3-rhamnosidementioning

confidence: 99%

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

2011

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Section: Quercetin 3-rhamnosidementioning

confidence: 99%

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

2011

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“…The inactivation of different influenza virus subtypes like as H9N2 by direct exposure to hydroxytyrosol, a phenolic derivative of the leaves and fruits of olive were associated with damage to virion integrity, but HA and NA functions were unaffected [33]. Furthermore, it has been shown that quercetin 3-rhamnoside inhibits virus replication in the initial stage of virus infection by indirect interaction with virus particles [6]. However, Haidari et al [14] evaluated the direct effect of a pomegranate polyphenols on influenza virus and observed inactivation was associated with loss of HA activity.…”

Section: Discussionmentioning

confidence: 99%

“…5 Virus was added to MDCK cells and after 1 h, the cells washed with PBS then DMEM was added. 6 DMEM was added and after 1 h, the cells washed with PBS then DMEM was added a,b,c Different superscripts denote significant differences among means in column for main effects (P B 0.05)…”

Section: Discussionmentioning

confidence: 99%

Antiviral activity of the oseltamivir and Melissa officinalis L. essential oil against avian influenza A virus (H9N2)

et al. 2016

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Lemon balm derivatives are going to acquire a novelty as natural and potent remedy for treatment of viral infections since the influenza viruses are developing resistance to the current antivirals widely. Oseltamivir, Melissa officinalis essential oil (MOEO) and their synergistic efficacy against avian influenza virus (AIV) subtype H9N2 were evaluated in vitro in MDCK cells at different time exposure by using TCID50, HA, Real Time PCR and HI assay. The results showed that MOEO could inhibit replication of AVI through the different virus replication phase (P B 0.05). Also the highest antiviral activity of MOEO was seen when AIV incubated with MOEO before cell infection. The TCID50/ml was reduced 1.3-2.1, 2.3-2.8, 3.7-4.5 log 10 than control group (5.6 log 10), HAU/50 ll was decreased 85-94, 71.4-94, 71.4-94 % and viral genome copy number/ll was brought down 68-95, 90-100, 89.6-99.9 % at pre-infection, post-infection and simultaneous stage, respectively. Hemagglutination inhibition result showed the MOEO was not able to inhibit agglutination of the chicken red blood cell (cRBC). Replication of the AVI was suppressed by the different concentration of oseltamivir completely or near 100 %. Also oseltamivir showed a synergistic activity with MOEO especially when oseltamivir concentration reduced under 0.005 mg/ml. The chemical composition was examined by GC-MS analysis and Its main constituents were identified as monoterpenaldehydes citral a, citral b. In conclusion, the findings of the study showed that lemon balm essential oil could inhibit influenza virus replication through different replication cycle steps especially throughout the direct interaction with the virus particles.

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“…To firmly establish the antiviral activity and adverse reactions like reactogenecity or toxicity of the purified phytomolecules, appropriate in vivo studies (animal models) and subsequent clinical trials are necessary. A bioactive flavonoid 'Baicalein' isolated from Chinese medicinal plant Scutellaria baicalensis Georgi showed antiviral properties using high-speed counter-current chromatography (HSCCC) technique [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58].…”

Section: Antiviral Molecules Of Plant Originmentioning

confidence: 99%

Antiviral Phytochemicals: An Overview

Kapoor¹,

Sharma²,

Kanwar³

2017

Biochem Physiol

100

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The pandemic of viral diseases during recent years has forced the scientific community to investigate less toxic antiviral phytomolecules instead of using nucleic acid analogues, protease inhibitors or other toxic synthetic molecules as antiviral therapeutics. Plants and many of their secondary metabolites because of the healing properties have been in traditional use throughout the world since ancient times. They provide us diverse bioactive phytochemicals which play synergetic role in maintaining human health. The development of clinical products from phyto-pharmaceuticals is a trending approach to look for ecofriendly therapeutic molecules. More than 50% of drugs used in Western nations are derived from plants or their constituents. Many plants have significant antiviral properties too. Very little information is available about plants of antiviral significance. This article briefly reviews various phytochemicals/bioactive molecules which have been isolated from plants and possess antiviral constituents, their mode of action and potential applications in treating/preventing viral diseases.

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Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication

Cited by 182 publications

References 25 publications

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

Antiviral activity of the oseltamivir and Melissa officinalis L. essential oil against avian influenza A virus (H9N2)

Antiviral Phytochemicals: An Overview

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