Inhibitory Effects of Pulse Bioactive Compounds on Cancer Development Pathways

Abstract

Previous studies suggest that pulses may have the potential to protect against cancer development by inhibiting pathways that result in the development of cancer. These pathways include those that result in inflammation, DNA damage, cell proliferation, and metastasis. Other studies have demonstrated extracts from pulses have the capacity to induce apoptosis specifically in cancer cells. Compounds reported to be responsible for these activities have included phenolic compounds, proteins and short chain fatty acids. The majority of the studies have been undertaken using in vitro cell culture models, however, there are a small number of in vivo studies that support the hypothesis that pulse consumption may inhibit cancer development. This review highlights the potential benefit of a diet rich in pulse bioactive compounds by exploring the anti-cancer properties of its polyphenols, proteins and short chain fatty acids.

Effect of Revtech thermal processing on volatile organic compounds and chemical characteristics of split yellow pea (Pisum sativum L.) flour

“…Many of these compounds are of interest to nutritional and functional food studies. For instance, dietary phenolics have been reported to play a major role in the prevention and treatment of cancer (Rao et al., 2018) and cardiovascular disease (Quiñones et al., 2013; Vita, 2005) due to their potent antioxidant (Amarowicz & Pegg, 2008; Heim et al., 2002), anti‐carcinogenic (Adebamowo et al., 2005), and anti‐inflammatory activities (Crozier et al., 2009). Peas, as other pulses, are good sources of phenolic compounds.…”

The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway

“…The phytochemicals that inhibit TLR4 activation are from the results demonstrating that phytochemicals decreased LPS-induced expression of cyclooxygenase-2, NF-κB and cytokine production. The pharmacological activity of phytochemicals against inflammation by targeting the TLR4 signaling pathway in many studies have been previously described [ 58 , 59 , 60 , 61 , 62 ].…”

Sturgeon (Acipenser)-Derived Chondroitin Sulfate Suppresses Human Colon Cancer HCT-116 Both In Vitro and In Vivo by Inhibiting Proliferation and Inducing Apoptosis

“…The majority of anti-cancer drugs and bioactives are able to inhibit abnormal proliferation and induce cytotoxic activity via cell cycle arrest and stimulation of apoptosis [24]. However, compared to pharmaceuticals, dietary bioactive compounds for cancer prevention are quite safe for normal cell metabolism and effective in accelerating the programmed cell death and interrupting the uncontrolled cell proliferation [25,26]. It is well-known that plant-derived bioactives, especially phenolic compounds, display a strong anti-cancer effect due to their anti-proliferative activity [27][28][29][30][31][32].…”