Inhibitory effects of Ponciri Fructus on testosterone-induced benign prostatic hyperplasia in rats

Jeon, WY; Ohn, S Kim; Seo, CS; Seong, Eunsol; Ja, Kim; Shin, HK; Yu, Kim; Lee, MY

doi:10.1055/s-0037-1608420

Cited by 3 publications

(7 citation statements)

References 13 publications

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“…This is due to excessive formation of free radicals and ROS in BPH. These findings are in line with previous studies [2,4,27]. On co-administration of FEN with BPH, there is marked improvement of the measured antioxidant and oxidant parameters indicating the protective effect of FEN against formation of free radicals which is supported by different studies [7,8,30].…”

Section: Discussionsupporting

confidence: 91%

“…Moreover, cleaved caspase3 immunoexpression significantly decreased in group III but highly overexpressed in group IV group. These findings are supported by different studies [2,18].…”

Section: Discussionsupporting

confidence: 83%

“…Benign prostatic hyperplasia is the most common disease of old-aged men affecting >90% of men between 70 and 80 years old. BPH is accompanied by serious urological problems such as lower urinary tract obstruction and repeated infection [2,4]. We aimed to evaluate a novel protective effect of FEN in induced BPH in rats.…”

Section: Discussionmentioning

confidence: 99%

“…Benign prostatic hyperplasia occurs due to imbalance between proliferation and apoptosis of cells in the prostate. BPH is accompanied by marked overgrowth of the prostatic tissue that is due to increase in the number of smooth muscle cells [2].…”

Section: Introductionmentioning

confidence: 99%

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Role of PPAR‐α agonist fenofibrate in the treatment of induced benign prostatic hyperplasia with dysplastic changes in rats

Refaie

Rifaai

Zenhom

2018

Fundamemntal Clinical Pharma

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Nearly all men who reach average life expectancy have prostate disease. The most common is benign prostatic hyperplasia (BPH). Peroxisome proliferator-activated receptor alpha (PPARα) had protective effect in different models, but still, there are no studies explain its role in BPH. So that we investigated the effect of fenofibrate (FEN) on induced BPH by testosterone propionate (TP) (3 mg/kg/day for 4 weeks) subcutaneous injection followed by FEN (300 mg/kg/day) was given orally for 4 weeks. We measured prostate weights changes, prostatic tissue superoxide dismutase (SOD), and malondialdehyde (MDA) levels. Prostate-specific antigen (PSA), dihydrotestosterone (DHT), and total antioxidant capacity (TAC) in serum were determined. The mRNA gene expressions of proliferating cell nuclear antigen (PCNA), PPARα, and glutathione peroxidase (GPx) in prostatic tissue were also measured by quantitative real-time polymerase chain reaction. In addition, the histopathological changes and activated caspase3 immunoexpression were evaluated. Our results showed that TP succeeded in induction of BPH, which was detected by significant increase in prostate weights, prostatic tissue MDA, serum levels of DHT, PSA, and mRNA gene expression of PCNA but significant decrease in PPARα and GPx gene expression. Moreover, TAC in serum and SOD level in prostate tissue decreased. The histopathological examination showed typical changes of BPH with dysplastic changes with marked decrease in activated caspase3 immunoexpression indicating marked suppression of the apoptotic process. FEN significantly improved all disturbed parameters of BPH model. Moreover, there are no dysplastic changes with co-administration of FEN to BPH induced group.

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Section: Discussionsupporting

confidence: 91%

“…Moreover, cleaved caspase3 immunoexpression significantly decreased in group III but highly overexpressed in group IV group. These findings are supported by different studies [2,18].…”

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of PPAR‐α agonist fenofibrate in the treatment of induced benign prostatic hyperplasia with dysplastic changes in rats

Refaie

Rifaai

Zenhom

2018

Fundamemntal Clinical Pharma

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“…A recent study also pointed out a beneficial effect against hyperlipidemia [33]. A growing body of evidence suggests the anti-inflammatory and gastroprotective effects of PFI [41]. The representative constituents of PFI are poncirin, which attenuates HCI-induced gastric lesions; hesperidin, which improves the delayed gastric emptying rate; neohesperidin, which stimulates mucus secretion; naringin, which prevents Fig.…”

Section: Poncirus Fructus Immaturus As One Of "Shin-ministers"mentioning

confidence: 99%

The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis

et al. 2021

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The prevalence of gastroesophageal reflux disease (GERD) is rapidly increasing due to the adoption of a Westernized lifestyle; at the same time, safe and efficient treatment is required due to the side effects and refractoriness of proton pump inhibitors (PPIs). The frequently used multi-compound treatment for GERD in the current traditional Korean medicine (TKM) clinical field comprises Crassostrea gigas Thunberg shell (CGTS), Bambusae Caulis in Taeniam (BCT), Ponciri Fructus Immaturus (PFI), Scutellaria baicalensis Georgi (SBG), medicated leaven (ML) and Glycyrrhizae Radix et Rhizoma (GRR). The current review was based on “Kun-Shin-Choa-Sa” theory and network analysis was conducted to explore the potential pharmacological activities, including efficacy and mechanisms of action of multi-compound treatment against GERD. Hypergeometric test results showed that the targets of multi-compound treatment are significantly associated with GERD gene sets, consistent with the literature review findings. In particular, the enrichment analysis indicated that the SBG targets are related to the IL-17 signaling pathway, bile secretion, small-cell lung cancer, and non-small cell lung cancer, corroborating the literature review, particularly concerning anti-inflammatory effect. In the literature review, CGTS and BCT, classified as “Kun,” play a role in anti-acid, anti-inflammatory, and anti-oxidative effects. The complementary “Shin” herbs, PFI and SBG, showed functions related to improving the prolonged gastric emptying rate, peristalsis, and a gastric cytoprotective effect. With the role of “Choa,” ML was suggested to inhibit H. pylori growth and diminish gastric acid secretion, consistent with the gastric acid secretion pathway in the enrichment analysis. However, the enrichment analysis did not show any significantly related pathways for CGTS and PFI, which may reflect the lack of information in the KEGG database in terms of the link between GERD, its mechanisms, and the abundance of minerals in CGTS. Despite the pharmacological potential of multi-compound treatment, this study should be corroborated by well-designed future experimental studies.

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Therapeutic effects of β‐caryophyllene on proliferative disorders and inflammation of the gerbil prostate

et al. 2021

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Background: The prostate is susceptible to changes in androgen levels, which can play an important role in the development of Benign Prostatic Hyperplasia (BPH).Natural compounds have beneficial properties for organisms and can be an important therapeutic strategy in the treatment of diseases. β-Caryophyllene (BCP) is a phytocannabinoid present in several medicinal and food plants species and has shown beneficial effects in different organs. However, little is known about its effects on the prostate. The present study seeks to evaluate the effects of exposure to BCP on the morphophysiology of the ventral prostate of adult gerbils supplemented with testosterone.Methods: Animals were distributed into four groups (n = 8/group): Intact control (C); β-Caryophyllene (BCP): β-Caryophyllene (50 mg/kg/day); Testosterone (T): animals received subcutaneous injections of Testosterone Cypionate (3 mg/Kg), on alternate days, for one month and were euthanized 30 days supplementation ended; Testosterone and β-Caryophyllene (TBCP): animals were exposed to testosterone cypionate (3 mg/Kg) to induce hyperplastic alterations followed by daily BCP (50 mg/ kg). Morphological, biometric, immunohistochemical, and serological analyses were performed.Results: Proliferative disorders and inflammatory foci were present in the ventral prostate of all experimental groups. An increase in the multiplicity of benign intraepithelial neoplasm and subepithelial inflammatory foci was observed in T group.The incidence of intraluminal inflammatory foci and microinvasive carcinoma was verified only in the T group. Cellular rearrangement and tissue remodeling occurred in the prostate of groups exposed to phytocannabinoids. A reduction was observed in the frequency of PHH3 and Cox2 markers in the prostatic epithelium of TBCP in comparison with T. A decrease in F4/80 and CD163 positive macrophages were also observed in the prostatic stroma of the TBCP group in comparison with T. The results suggest that BCP had favorable effects on BPH, reducing the proliferation and frequency of some inflammatory cells.

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Inhibitory effects of Ponciri Fructus on testosterone-induced benign prostatic hyperplasia in rats

Cited by 3 publications

References 13 publications

Role of PPAR‐α agonist fenofibrate in the treatment of induced benign prostatic hyperplasia with dysplastic changes in rats

Role of PPAR‐α agonist fenofibrate in the treatment of induced benign prostatic hyperplasia with dysplastic changes in rats

The potential of pharmacological activities of the multi-compound treatment for GERD: literature review and a network pharmacology-based analysis

Therapeutic effects of β‐caryophyllene on proliferative disorders and inflammation of the gerbil prostate

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