Inhibitory effects of PGA1 and TRI on the apoptosis of cardiac microvascular endothelial cells of rats

Peng, Wenhua; Wang, Jiali; Ren, Yan; Gao, Yanxiang; Li, Geng; Wang, Yong

doi:10.3892/etm.2017.5079

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…According to modern pharmacological findings 3 , the main compounds in NRER are terpenoids, volatile oils, flavonoids, coumarins, lignans, sugars, etc., and NRER neophytum can affect the cellular cAMP-PKA conduction pathway, inhibit calcium overload, and promote the restoration of cardiac function 4 ; it can also inhibit cardiac hypertrophy by inhibiting the expansion of the cell surface area induced by angiotensin II (AngII) 5 . Salidroside mainly contains ketones, phenylalkyl glycosides, coumarins, organic acids, polysaccharides, amino acids, vitamins, etc.…”

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confidence: 99%

Mechanism of Nardostachyos Radix et Rhizoma (NRER)-Salidroside in the Treatment of Premature Ventricular Beats Based on Network Pharmacology and Molecular Docking

Liu,

Chen

2023

Preprint

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Objective To analyse the mechanism of NRER-Salidroside in the treatment of premature ventricular tachycardia by using network pharmacology and molecular docking and to provide the basis for developing the use of clinical traditional Chinese medicine. Method The chemical compositions of NRER and salidroside were determined, and their related targets were predicted. The disease-related targets were obtained by searching the common disease databases Genecards, OMIM and TTD, and the intersection between the predicted targets and the disease targets was determined. Then, the STRING database was used to set up a network of protein‒protein interactions (PPIs) between NRER and salidroside and the common targets of PVB and establish a network of PPIs. Result Forty-one active components of NRSR-Salidroside were detected, with 420 potential targets of action, with a total of 1688 PVB targets, and the top 10 core targets of drug-disease degree values were AKT1, TNF, GAPDH, SRC, PPARG, EGFR, PTGS2, ESR1, MMP9, and STAT3. KEGG analysis indicated that its mechanism may be related to the calcium signalling pathway, cancer signalling pathway, AGE-RAGE signalling pathway and other pathways. Molecular docking suggested that most of the active ingredients of the NRSR-salidroside pairs were well bound to the core targets. Conclusion Based on novel network pharmacology and molecular docking validation research methods, we revealed for the first time the potential mechanism of salidroside in PVB therapy.

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confidence: 99%

Mechanism of Nardostachyos Radix et Rhizoma (NRER)-Salidroside in the Treatment of Premature Ventricular Beats Based on Network Pharmacology and Molecular Docking

Liu,

Chen

2023

Preprint

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The role of some lipids and their metabolites in programmed cell death (lipoapoptosis).

Ishutina

Andrievskaya

2022

Acta biomedica scientifica

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In recent years, the understanding of the mechanisms involved in the regulation of lipoapoptosis signaling pathways has expanded considerably. However, many mechanisms of apoptosis induction by lipids as well as molecules mediating intracellular and systemic signals belonging to AOS/enzyme-dependent phospholipid metabolites are not completely clear.This review summarizes the current understanding of the mechanisms of apoptotic cell death induction by some lipid molecules. Literature search was performed in the database “PubMed”, “eLIBRARY” using key words: “apoptosis”, “lipids”, “fatty acids”, “eicosanoids”, “reactive oxygen species”.A brief characterization of the signaling pathways of apoptosis is given. The role of reactive oxygen species and their dependent products of lipid peroxidation in the regulation of the main signaling pathways of apoptosis are shown. Particular attention is paid to the product of phospholipid metabolism – 4-hydroxynonenal.Pro- and anti-apoptotic effects of some prostaglandins are demonstrated. Arguments are presented that prostaglandins of series J and D are pro-apoptotic in most cells, and this effect depends on activation of the prostanoid receptor DP2 and on reduction of AKT kinase activity. In contrast, the E-series prostaglandins and hydroxyecosatetraenoic acid act opposite to the J-series and D-series prostaglandins, reducing apoptosis by activating AKT and increasing Bcl-2 protein expression.The role of individual fatty acids involved in the initiation and transduction of pro-apoptotic and anti-apoptotic signals is assessed. It was shown that saturated fatty acids have the maximum damaging potential than their unsaturated counterparts. An in-depth understanding and deciphering of the mechanisms by which lipids and their metabolites modulate the activation of signaling pathways of programmed cell death can help to develop therapeutic strategies to prevent a number of diseases associated with impaired regulation of apoptosis.

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Inhibitory effects of PGA1 and TRI on the apoptosis of cardiac microvascular endothelial cells of rats

Cited by 2 publications

References 13 publications

Mechanism of Nardostachyos Radix et Rhizoma (NRER)-Salidroside in the Treatment of Premature Ventricular Beats Based on Network Pharmacology and Molecular Docking

Mechanism of Nardostachyos Radix et Rhizoma (NRER)-Salidroside in the Treatment of Premature Ventricular Beats Based on Network Pharmacology and Molecular Docking

The role of some lipids and their metabolites in programmed cell death (lipoapoptosis).

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