Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats

Koçyiğit, Ümit M.; Taşkıran, Ahmet Şevki; Taslimi, Parham; Yokuş, Ahmet; Temel, Yusuf; Gülçın, İlhami

doi:10.1002/jbt.21972

Cited by 46 publications

(59 citation statements)

References 30 publications

(53 reference statements)

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“…[54] In this study, we obtained the effects of novel amides of 1,1-bis-(carboxymethylthio)-1arylethanes derivatives (1-11) against hCA I, hCA II, AChE, and BChE enzymes. [55] In addition, hCA II is the most TA B L E 1 The enzyme inhibition results of novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) extensively studied and characterized of the hCA isoforms. hCA II is often associated with several diseases such as glaucoma, osteoporosis, and renal tubular acidosis.…”

Section: Discussionmentioning

confidence: 99%

“…In conclusion, we synthesized of novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). All of compounds have been characterized by using 1 H NMR and 13 C NMR methods.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7] CAs are extensively found in all kingdoms of life and are classified in seven groups: -, -, -, -, -, -, and -CAs. [5][6][7] CAs are extensively found in all kingdoms of life and are classified in seven groups: -, -, -, -, -, -, and -CAs.…”

Section: Introductionmentioning

confidence: 99%

“…[25][26][27][28][29] In this study, we have performed the synthesis of well-defined novel amide of 1,1-bis-(carboxymethylthio)-1-arylethanes derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). [25][26][27][28][29] In this study, we have performed the synthesis of well-defined novel amide of 1,1-bis-(carboxymethylthio)-1-arylethanes derivatives (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Novel amides of 1,1‐bis‐(carboxymethylthio)‐1‐arylethanes: Synthesis, characterization, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibitory properties

Taslimi

Osmanova

Çağlayan

et al. 2018

J Biochem & Molecular Tox

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The thiolation reaction was carried out in a benzene solution at 80°C and p-substituted ketones and mercaptoacetic acid in a molar ratio (1:4) of in the presence of a catalytic amount of toluene sulfonic acids. The enzyme inhibition activities of the novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes derivatives were investigated. These novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes derivatives showed good inhibitory action against acetylcholinesterase (AChE) butyrylcholinesterase (BChE), and human carbonic anhydrase I and II isoforms (hCA I and II). AChE inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. Many clinically established drugs are carbonic anhydrase inhibitors, and it is highly anticipated that many more will eventually find their way into the market. The novel synthesized compounds inhibited AChE and BChE with K values in the range of 0.64-1.47 nM and 9.11-48.12 nM, respectively. On the other hand, hCA I and II were effectively inhibited by these compounds, with K values between 63.27-132.34 and of 29.63-127.31 nM, respectively.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel amides of 1,1‐bis‐(carboxymethylthio)‐1‐arylethanes: Synthesis, characterization, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibitory properties

Taslimi

Osmanova

Çağlayan

et al. 2018

J Biochem & Molecular Tox

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“…Treatment with Atosiban has been shown to have a depressive effect on carbonic anhydrase (CA) [7]. CA is an enzyme which has a key role in facilitating acid-base regulation within the kidneys.…”

Section: Tocolyticsmentioning

confidence: 99%

Renal Consequences of Therapeutic Interventions in Premature Neonates

Fryer¹,

Welsh²

2019

Nephron

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An infant is described as “preterm” if they are born before 37 weeks of gestation. As nephrogenesis does not complete until 36 weeks of gestation, premature infants are often born with underdeveloped kidneys. Current evidence strongly suggests that this leaves those born prematurely more susceptible to developing kidney-related conditions later in life. Although the incidence of premature birth steadily increases each year in the United Kingdom, reports of perinatal death following preterm labour are falling. This is mainly attributed to the development of antenatal drugs, such as tocolytics, corticosteroids and antibiotics. Though these drugs have effectively reduced the incidence of premature-birth-related deaths, evidence suggests that they may be nephrotoxic. This review will describe the experimental evidence that some therapeutics are disadvantageous to kidney functions later on in life.

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Synthesis, characterization and biological evaluation of N‐substituted triazinane‐2‐thiones and theoretical–experimental mechanism of condensation reaction

Sujayev

Taslimi

Kaya

et al. 2019

Applied Organom Chemis

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The synthesis of triazinthions and their reactions with some nucleophilic reagents have been investigated during this scientific study. Thus, thiourea with a single component has been synthesized as a result of concomitant reactions of aldehyde and amines trials. The structure of the synthesized compounds was confirmed by 1H, 13C NMR spectroscopy methods. The inhibitory effects of novel N‐substituted triazinane‐2‐thione derivatives on acetylcholinesterase (AChE) activity were performed according to the spectrophotometric method of Ellman et al. These novel N‐substituted triazinane‐2‐thiones derivatives were effective inhibitors of the α‐glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and Acetylcholinesterase (AChE) enzymes with Ki values in the range of 1.01 ± 0.28 to 2.12 ± 0.37 nm for α‐glycosidase, 13.44 ± 4.39 to 74.98 ± 6.25 nm for hCA I, 10.41 ± 4.8 to 72.6 ± 17.66 nm for hCA II, 36.82 ± 9.95 to 108.48 ± 1.17 nm for AChE, and 624.62 ± 100.34 to 1124.16 ± 205.14 nm for α‐glycosidase, respectively.

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Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats

Cited by 46 publications

References 30 publications

Novel amides of 1,1‐bis‐(carboxymethylthio)‐1‐arylethanes: Synthesis, characterization, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibitory properties

Novel amides of 1,1‐bis‐(carboxymethylthio)‐1‐arylethanes: Synthesis, characterization, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibitory properties

Renal Consequences of Therapeutic Interventions in Premature Neonates

Synthesis, characterization and biological evaluation of N‐substituted triazinane‐2‐thiones and theoretical–experimental mechanism of condensation reaction

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