Abstract:Abstract-Inhibitory effects of the calcium channel blocker nisoldipine on angio tensin II-induced antidiuresis were investigated in anesthetized dogs, and the findings were compared with those of saralasin.Intrarenal arterial infusion of 10 ng/kg/min angiotensin II resulted in marked decreases in renal blood flow (RBF) and urine formation, with a relatively moderate decrease in glomerular filtration rate. There were marked reductions in the fractional excretion of lithium, which is used as an index of the frac… Show more
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