Inhibitory effects of long-term administration of ferulic acid on astrocyte activation induced by intracerebroventricular injection of β-amyloid peptide (1–42) in mice

Cho, Jae-Young; Kim, Hee‐Sung; Kim, Do-Hoon; Yan, Ji-Jing; Suh, Hong‐Won; Song, Dong‐Keun

doi:10.1016/j.pnpbp.2005.04.022

Cited by 68 publications

(66 citation statements)

References 41 publications

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“…Also, apoptotic features such as fragmentation of DNA, alterations in mitochondria and a decreased Bax (proapoptotic) to Bcl-2 (antiapoptotic) ratio in cells treated with b-amyloid were attenuated by the T. aestivum L. extract (47). Apoptotic death of the SH-SY5Y cells exposed to Ab [25][26][27][28][29][30][31][32][33][34][35] , manifested by a decrease in the mitochondrial transmembrane potential, was blocked after pretreatment with the T. aestivum extract. Also, the intracellular accumulation of reactive oxygen species was diminished by the presence of the extract.…”

Section: Resultsmentioning

confidence: 99%

“…The b-amyloid-and scopolamine-treated mice showed increased reaction times in a spatial memory test (water maze test), but the application of the T. aestivum extract reversed this effect. The total dietary fibre from T. aestivum L. effectively inhibited an Ab [25][26][27][28][29][30][31][32][33][34][35] -induced decrease in the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. The authors concluded that the attenuation of the cytotoxicity and the memory deficits caused by scopolamine could be attributed to the presence of phenolic acids in T. aestivum L.…”

Section: Resultsmentioning

confidence: 99%

“…Sodium ferulate partly reduced the decrease in phosphorylated extracellular signal-regulated kinases ERK1 and ERK2 and completely reversed the decrease in phosphorylated Akt/protein kinase B induced by b-amyloid- (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) in the hippocampal regions of the rat brain (66). Also, sodium ferulate inhibited a b-amyloid-(1-40)-induced increase in phosphorylated-p38 mitogen-activated protein kinase (MKK3/MKK6), partly prevented a decrease in phosphorylated MAPKAPK2 and Hsp27 expression, and inhibited the activation of caspase cascades (caspase-3, caspase-7 and caspase-3 activities) (67).…”

Section: Phenolic Acids As Efficient Ache and Bche Inhibitorsmentioning

confidence: 94%

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Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Szwajgier

Borowiec

2012

J. Inst. Brew.

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Anticholinesterase activities of mashes produced using wheat ('Wheat Pale') or barley malts ('Pilsner', 'Pale Ale', 'Munich Light', 'Carahell' or 'Carared') were studied by spectrophotometric method. The highest inhibition of acetylcholinesterase and butyrylcholinesterase was observed at 52 C and/or 64 C, followed by a decrease or stabilization of the activity at 72 C. Changes in the total phenolics content in the test mashes were correlated with changes in the acetylcholinesterase and/or butyrylcholinesterase activities. Phenolic acids were singled out from phenolic compounds for more detailed studies owing to their simplicity and structural similarity to well-known cholinesterase inhibitors. The main phenolic acids in the test malts were ferulic, gallic, p-coumaric and vanillic acids followed by chlorogenic, caffeic, syringic, p-OH-benzoic, sinapic and protocatechuic acids. The anticholinesterase activities of the phenolic acids were studied using model standard solutions at concentrations similar to the maximal content of these compounds in the test mashes. Among the phenolic acids, p-coumaric acid had the largest share in the anticholinesterase activity, even though it was present in the test mashes at a significantly lower concentration (~0.38 mM L À1 ) than ferulic acid (~1.00 mM L À1 ). Sinapic acid and p-OH-benzoic acid (0.03 and 0.01 mM L À1 , respectively) were equally efficient inhibitors as ferulic acid at~1.00 mM L À1 . This preliminary study should be extended to other phenolic compounds from malt (wort) in the near future.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Phenolic Acids As Efficient Ache and Bche Inhibitorsmentioning

confidence: 94%

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Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Szwajgier

Borowiec

2012

J. Inst. Brew.

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“…Ferulic acid was also protected against memory and learning deficit induced β-amyloid peptide in mice and had antioxidant activity (Cho et al ; 2005). Thus, it seems that gallic acid, vanillic acid and ferulic acid may affect effect of SFC.…”

Section: Disscusionmentioning

confidence: 99%

Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata

Weon

Yun

Lee

et al. 2014

Biomolecules & Therapeutics

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Codonopsis lanceolata has been used as an herbal medicine for several lung inflammatory diseases, such as asthma, tonsillitis, and pharyngitis. Previously, we showed the neuroprotective effect of steamed and fermented C. lanceolata (SFC) in vitro and in vivo. In the current study, the treatment of HT22 cells with SFC decreased glutamate-induced cell death, suggesting that SFC protected HT22 cells from glutamate-induced cytotoxicity. Based on these, we sought to elucidate the mechanisms of the neuro-protective effect of SFC by measuring the oxidative stress parameters and the expression of Bax and caspase-3 in HT22 cells. SFC reduced contents of ROS, Ca2+ and NO. Moreover, SFC restored contents of glutathione and glutathione reductase as well as inhibited Bax and caspase-3 activity in HT22 cells. These results indicate that steamed and fermented C. lanceolata (SFC) extract protected HT22 cells by anti-oxidative effect and inhibition of the expression of Bax and caspase-3.

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“…injection of Aβ1-42 into mice effectively induces Aβ toxicity in vivo, as demonstrated by impairment in passive avoidance performance, increases in immunoreactivities of the astrocyte marker GFAP and IL-1 in the hippocampus, and reduction in ACh levels in the cortex [4,17]. In the current study, we evaluated the effects of ADA extract on various Aβ-induced changes after i.c.v.…”

Section: The Effects Of Ada Extract On Various Aβ-induced Changes Aftmentioning

confidence: 99%

Protective effects ofAcanthopanax divaricatusextract in mouse models of Alzheimer's disease

Yan¹,

Ahn²,

Jung³

et al. 2014

Nutr Res Pract

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BACKGROUND: Acanthopanax divaricatus var. albeofructus (ADA) extract has been reported to have anti-oxidant, immunomodulatory, and anti-mutagenic activity. MATERIALS/METHODS:We investigated the effects of ADA extract on two mouse models of Alzheimer's disease (AD); intracerebroventricular injection of β-amyloid peptide (Aβ) and amyloid precursor protein/presenilin 1 (APP/PS1)-transgenic mice. RESULTS: Intra-gastric administration of ADA stem extract (0.25 g/kg, every 12 hrs started from one day prior to injection of Aβ1-42 until evaluation) effectively blocked Aβ1-42-induced impairment in passive avoidance performance, and Aβ1-42-induced increase in immunoreactivities of glial fibrillary acidic protein and interleukin (IL)-1α in the hippocampus. In addition, it alleviated the Aβ1-42-induced decrease in acetylcholine and increase in malondialdehyde levels in the cortex. In APP/PS1-transgenic mice, chronic oral administration of ADA stem extract (0.1 or 0.5 g/kg/day for six months from the age of six to 12 months) resulted in significantly enhanced performance of the novel-object recognition task, and reduced amyloid deposition and IL-1β in the brain. CONCLUSIONS:The results of this study suggest that ADA stem extract may be useful for prevention and treatment of AD.

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Inhibitory effects of long-term administration of ferulic acid on astrocyte activation induced by intracerebroventricular injection of β-amyloid peptide (1–42) in mice

Cited by 68 publications

References 41 publications

Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Neuroprotective Effect of Steamed and Fermented Codonopsis lanceolata

Protective effects ofAcanthopanax divaricatusextract in mouse models of Alzheimer's disease

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