Inhibitory effects of Lactobacillus plantarum metabolites on porcine epidemic diarrhea virus replication

Huang, Sung-Wei; Yu, Qiuhan; Xie, Luyi; Ran, Ling; Wang, Kai; Yang, Yang; Gan, Lu; Song, Zhenhui

doi:10.1016/j.rvsc.2021.07.002

Cited by 15 publications

(15 citation statements)

References 24 publications

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“…Previous reports found that L. plantarum metabolites can inhibit the adsorption of transmissible gastroenteritis virus (TGEV) on ST cells ( 22 ). Moreover, both L. plantarum metabolites and L. plantarum exopolysaccharides showed a good inhibitory effect on porcine epidemic diarrhea virus (PEDV) ( 23 ) and rotaviruses (RV) ( 24 ), and the treatments that exerted the excellent effects have been repeatedly proved. This could be due to the complex composition of metabolites, which blocks virus adsorption, alleviates inflammatory responses, and induces immunity ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

The Probiotic Attributes and Anti-pseudorabies Virus Evaluation of Lactobacillus Isolates

Yang

Yan

et al. 2022

Front. Vet. Sci.

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The emergence of pseudorabies virus (PRV) variants brings serious harm to the swine industry, and its effective treatments are limited at present. As one of the probiotics, the Lactobacillus species have beneficial characteristics of regulating the balance of intestinal flora, inhibiting the growth of pathogenic bacteria and viruses' proliferation, and improving self-immunity. In this study, Lactobacillus plantarum HN-11 and Lactobacillus casei HN-12 were selected and identified through morphology observation, Gram stain microscopy, 16S rRNA sequencing analysis, and specific amplification of the recA gene and pheS gene. All tested isolates exhibited rapid adaptation to the different conditions, excellent acid, and bile tolerance, and sensitivity to Salmonella, Staphylococcus aureus, and Escherichia coli. The antibiotic susceptibility assay displayed the isolates sensitive to most antibiotics and resistant to Lincomycin and Norfloxacin. Moreover, the supernatants of HN-11 and HN-12 inhibited PRV proliferation in ST cells. The results of animal experiments showed that supplementing the challenged mice with the supernatants of Lactobacillus isolates in advance delayed the course of the disease. PRV was detected in the heart, liver, spleen, lung, kidney, and brain tissues of dead mice in the test groups, and its copies in the lungs were significantly decreased compared with the control mice (P < 0.05). These findings proved the advantages of L. plantarum and L. casei as potential probiotic cultures, which could provide a basis for its application in microecological preparations and functional formulations.

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Section: Discussionmentioning

confidence: 99%

The Probiotic Attributes and Anti-pseudorabies Virus Evaluation of Lactobacillus Isolates

Yang

Yan

et al. 2022

Front. Vet. Sci.

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“…cell-free supernatant, heat-killed supernatant, and cell-mass), the cell-free supernatant showed the most efficient anti-influenza A activity against host cells (Rather et al, 2015 ). In other studies, the supernatant obtained from L. plantarum 8 RA 3 suspension displayed a significant inhibitory effect on viral reproduction in vitro (Soloveva et al, 2021 ), and the supernatant of L. plantarum CQ2017RC suspension repressed the replication of porcine epidemic diarrhea virus (Huang et al, 2021 ). Furthermore, the exopolysaccharides (EPS), one of the major components in the supernatant, was revealed to be the key active component, affecting the viral infectivity and host immune response (Huang et al, 2021 ).…”

Section: Curcuminmentioning

confidence: 91%

“…In other studies, the supernatant obtained from L. plantarum 8 RA 3 suspension displayed a significant inhibitory effect on viral reproduction in vitro (Soloveva et al, 2021 ), and the supernatant of L. plantarum CQ2017RC suspension repressed the replication of porcine epidemic diarrhea virus (Huang et al, 2021 ). Furthermore, the exopolysaccharides (EPS), one of the major components in the supernatant, was revealed to be the key active component, affecting the viral infectivity and host immune response (Huang et al, 2021 ). Also, the effect of EPS obtained from L. plantarum LRCC5310 on antiviral and immune-relieving functions has been reported (Kim et al, 2018 ).…”

Section: Curcuminmentioning

confidence: 91%

“…L. plantarum is a lactic acid bacteria which exists in various types of food (Arasu et al, 2016 ). Certain strains from this species appear to exert antiviral effects against several types of viruses (Arena et al, 2018 ; Huang et al, 2021 ; Kim et al, 2018 ; Liu et al, 2020 ; Park et al, 2013 ; Rather et al, 2015 ; Soloveva et al, 2021 ; Sunmola et al, 2019 ). According to a report, intranasal or oral treatment of L. plantarum strain DK119 (10 9 CFU per mouse), protected the mice from influenza A virus infection, reducing lethality, weight loss, and virion loads in the lungs (Park et al, 2013 ).…”

Section: Curcuminmentioning

confidence: 99%

“…According to a report, intranasal or oral treatment of L. plantarum strain DK119 (10 9 CFU per mouse), protected the mice from influenza A virus infection, reducing lethality, weight loss, and virion loads in the lungs (Park et al, 2013 ). Noteworthily, in several research studies, the cell supernatant of L. plantarum emerged as the key player of the suppressive activity (Huang et al, 2021 ; Rather et al, 2015 ; Soloveva et al, 2021 ). In one study, among the different fractions of L. plantarum YML009 (e.g.…”

Section: Curcuminmentioning

confidence: 99%

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Functional foods with antiviral activity

Kim

et al. 2022

Food Sci Biotechnol

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Viruses are known to cause a variety of diseases, ranging from mild respiratory diseases, such as the common cold, to fatal illnesses. Although the development of vaccines and targeted drugs have significantly improved the mortality rate and disease severity against a number of viral infections, there are still many viruses without proper treatment/prevention options and newly emerging viruses can pose serious health threats. For instance, the coronavirus disease 2019 (COVID-19) pandemic is producing significant healthcare and socio-economic burden worldwide, which may jeopardize the lives and livelihoods for years to come. Studies have identified functional foods with antiviral activity. Certain foods may target the viral life cycle or modulate the host immune system to enhance defense against viral infections. In this review, we will discuss some of the food products reported to display protective effects against viruses including the influenza virus, human immunodeficiency virus, and severe acute respiratory syndrome coronavirus 2.

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Radix Isatidis polysaccharide (RIP) alleviates QX-genotype infectious bronchitis virus-induced interstitial nephritis through the Nrf2/NLRP3/Caspase-3 signaling pathway

Xiang,

Huang,

Shen

et al. 2024

International Journal of Biological Macromolecules

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Inhibitory effects of Lactobacillus plantarum metabolites on porcine epidemic diarrhea virus replication

Cited by 15 publications

References 24 publications

The Probiotic Attributes and Anti-pseudorabies Virus Evaluation of Lactobacillus Isolates

The Probiotic Attributes and Anti-pseudorabies Virus Evaluation of Lactobacillus Isolates

Functional foods with antiviral activity

Radix Isatidis polysaccharide (RIP) alleviates QX-genotype infectious bronchitis virus-induced interstitial nephritis through the Nrf2/NLRP3/Caspase-3 signaling pathway

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