Inhibitory effects of Korean medicinal plants and camelliatannin H from Camellia japonica on human immunodeficiency virus type 1 protease

Abstract

To identify substances with anti-human immunodeficiency virus (HIV) activity in traditional medicines, 101 extracts of Korean medicinal plants were screened for their inhibitory effects on HIV type 1 protease (PR). The enzyme activity was determined by HPLC. Of the extracts tested, strong inhibitory effects were observed in the acetone extracts of the pericarp and leaves of Camellia japonica, the water extract of the leaves of Sageretia theezans and the methanol extract of the aerial part of Sophora flavescens. Camelliatannin H from the pericarp of C. japonica, showed a potent inhibitory activity on HIV-1 PR with IC(50) of 0.9 microM.

Distribution of 127 edible plant species for antioxidant activities by two assays

“…26 Flavonoids, limonoids, phytols, toosendanin and cedrelone have been isolated from leaves and stems of Chinese cedar. 27,28 The Damocles tree, also called the sword fruit tree, originated from Southeast Asia, and its young leaves and flowers are often cooked as a side dish with rice. 25 Fruit extracts show strong antimutagenesis activity, which is highly correlated with a high concentration of baicalein (5,6,7-trihydroxyflavone) in the leaves.…”

Camellianoside, a Novel Antioxidant Glycoside from the Leaves ofCamellia japonica

“…Furthermore, some of the tannins from leaves, flower buds, and fruits have been shown to have an inhibitory effect on HIV-1 protease. [12][13][14][15][16][17] In the course of our search for useful metabolites in plants, we found a novel flavonol glycoside together with three known flavonol glycosides from the leaves of C. japonica and named the novel metabolite camellianoside (1). We report in this paper the structural elucidation of 1 and the diphenylpicrylhydrazyl (DPPH) free radical scavenging activities of 1 and the three analogs.…”

Triterpenoids from Camellia japonica and Their Cytotoxic Activity

“…Furthermore, some of the tannins from leaves, flower buds, and fruits have been shown to have an inhibitory effect on human immunodeficiency virus-1 (HIV-1) protease. [13][14][15][16][17][18] In the present paper, we describe the isolation, structural determination and their cytotoxic activity against A549, LLC, HL-60 and MCF-7 cancer cell lines of the isolated compounds.…”