2011
DOI: 10.1186/1472-6882-11-80
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Inhibitory effects of inhaled complex traditional Chinese medicine on early and late asthmatic responses induced by ovalbumin in sensitized guinea pigs

Abstract: BackgroundMany formulae of traditional Chinese medicines (TCMs) have been used for antiasthma treatment dating back many centuries. There is evidence to suggest that TCMs are effective as a cure for this allergenic disease administered via gastric tubes in animal studies; however, their efficacy, safety and side effects as an asthmatic therapy are still unclear.MethodsIn this study, guinea pigs sensitized with ovalbumin (OVA) were used as an animal model for asthma challenge, and the sensitization of animals b… Show more

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Cited by 13 publications
(38 citation statements)
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References 37 publications
(45 reference statements)
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“…In human ASM with epithelium removed, [6]-gingerol, [8]-gingerol, and [6]-shogaol, but not [10]-gingerol, induced significant relaxation compared with DMSO vehicle control samples and food-grade ginger ( Figure 1B;*P , 0.05, compared with DMSO; $ P , 0.05, compared with food-grade ginger; n ¼ 5-9). All relaxations began within 2 minutes of the addition of the compounds, and the percentage of relaxation achieved from the plateau of AChinduced contraction was calculated at 30 minutes.…”
Section: Isolated Components Of Ginger Significantly Relax Human and mentioning
confidence: 99%
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“…In human ASM with epithelium removed, [6]-gingerol, [8]-gingerol, and [6]-shogaol, but not [10]-gingerol, induced significant relaxation compared with DMSO vehicle control samples and food-grade ginger ( Figure 1B;*P , 0.05, compared with DMSO; $ P , 0.05, compared with food-grade ginger; n ¼ 5-9). All relaxations began within 2 minutes of the addition of the compounds, and the percentage of relaxation achieved from the plateau of AChinduced contraction was calculated at 30 minutes.…”
Section: Isolated Components Of Ginger Significantly Relax Human and mentioning
confidence: 99%
“…The individual components of ginger, [6]-gingerol, [8]-gingerol, and [10]-gingerol, as well as [6]-shogaol (100 mM), were examined in contractile studies for their ability to relax ASM precontracted with ACh, compared with 50 mg/ml food-grade ginger. In human ASM with epithelium removed, [6]-gingerol, [8]-gingerol, and [6]-shogaol, but not [10]-gingerol, induced significant relaxation compared with DMSO vehicle control samples and food-grade ginger ( Figure 1B;*P , 0.05, compared with DMSO; $ P , 0.05, compared with food-grade ginger; n ¼ 5-9).…”
Section: Isolated Components Of Ginger Significantly Relax Human and mentioning
confidence: 99%
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