Inhibitory effects of Indonesian medicinal plants on the infection of herpes simplex virus type 1

Nawawi, As'ari; Nakamura, Norio; Hattori, Masao; Kurokawa, Mineo; Shiraki, Kimíyasu

doi:10.1002/(sici)1099-1573(199902)13:1<37::aid-ptr382>3.0.co;2-s

Cited by 65 publications

(16 citation statements)

References 16 publications

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“…6,10,12,13,15) These compounds have been shown to act either in the early stage of adsorption or on virus surface structures thereby inhibiting penetration into susceptible cells. These modes of action favor the basis of the virucidal protocol as the more relevant approach for determining antiviral effect (eventually, prophylactic, where cells are treated before the infection).…”

Section: Resultsmentioning

confidence: 99%

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Antiviral Effect of Guazuma ulmifolia and Stryphnodendron adstringens on Poliovirus and Bovine Herpesvirus

Felipe

Rincão

Benati

et al. 2006

Biological & Pharmaceutical Bulletin

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Works on antiviral compounds date back to the 1950s, but for several reasons, only a couple of drugs were approved for clinical use about a decade later. To date, many antiviral drugs have been developed after extensive research and demanding trials, some of them with selective mechanisms against viral replication. 1) Although the primary focus has been on synthetic products, the number of natural compounds with antiviral action for different DNA and RNA viruses that are being studied is increasing. Many phytochemical compounds are being investigated based primarily on ethnopharmacologic knowledge and have been considered of great importance in new drug development. 2)Extracts of many plant species, such as Tridax procumbens, Carissa carandas, Mallotus philippensis, Streblus aspere, Terminatta alata, Macaranga pustulata, Sibbaldia micropetala, Hypericum cordifolium, H. uralum and Maesa macrophylla were found to be active against the replication of poliovirus and herpes simplex-1 (HSV-1), with some of them also active against Sindbis virus.3,4) A methanol extract of Annona muricata and aqueous extract of Petunia myctaginiflora were shown to inhibit HSV-1 cytopathic effect in Vero cells, at a concentration of 1 mg/ml. 5)Methanol extracts of Indonesian plants were tested for cytotoxicity and antiviral activity (HSV-1 and poliovirus) in murine and human cell lines. Piper aduncum was found to be active on poliovirus, while Elytranthe tubaeflora and Melastoma malabathricum inhibited HSV-1. 6) Dengue virus was inhibited by an aqueous extract of Azadirachta indica when assayed in mice. 7)Stem bark of Stryphnodendron adstringens (MART.) COV-ILLE, Leguminosae, popularly known in our country as barbatimão, has been empirically used as wound healing, astringent, antimicrobial, antifungal, antidiarrheal and hypoglycemic agents.8) Similarly, Guazuma ulmifolia LAM., Sterculiaceae, popularly known as mutamba, is known to have medicinal properties, such as wound healing, antiulcerogenic, hypoglycemic and antimicrobial. 9) G. ulmifolia aqueous and methanol fractions were found to inhibit HSV-1 replication, respectively, by 16.8% and 4.5%, at a concentration of 100 mg/ml, in a study of various plants. Those showing antiviral activity in vitro were also tested in HSV-1 infected mice. Melaleuca leucadendron and Nephelium lappaceum reduced mortality and delayed the appearance of lesions. 10)Among plant antiviral compounds, anthraquinones found in Aloe barbadensis inhibited HSV-1, HSV-2, varicela-zoster, pseudorabies and influenza.11) Stevia rebaudiana polysaccharides inhibited adsorption of human rotavirus in MA-104 cells.12) Flavonoids present in Troillius chinensis flowers also inhibited parainfluenza in HEp-2 cells.13) Quassia africana extracts were tested for HSV-1, coxsackie B2, polio-1, measles, Semliki Forest virus and vesicular stomatitis virus, where simalikalactone D was found to be responsible for the antiviral effect.14) Anagyrine, oxymatrine, sophoranol, wogonin and oroxylin found in Sophora flavescens and Scutellaria b...

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Section: Resultsmentioning

confidence: 99%

“…Melaleuca leucadendron and Nephelium lappaceum reduced mortality and delayed the appearance of lesions. 10) Among plant antiviral compounds, anthraquinones found in Aloe barbadensis inhibited HSV-1, HSV-2, varicela-zoster, pseudorabies and influenza.…”

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confidence: 99%

Antiviral Effect of Guazuma ulmifolia and Stryphnodendron adstringens on Poliovirus and Bovine Herpesvirus

Felipe

Rincão

Benati

et al. 2006

Biological & Pharmaceutical Bulletin

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“…The roots, bark, and leaves have various uses in medicine and in the production of dyes. Previous studies have shown N.lappaceum rind extract to exhibit high antioxidant activity (Palanisamy et al, 2008), antibacterial activity (Thitilertdecha et al, 2010) and anti-Herpes Simplex virus type 1 (Nawawi A, 1999). Recently in our laboratory, N.lappaceum rind was also shown to have anti hyperglycemic potential (Palanisamy, Uma et al, 2011).…”

Section: Rind Of Rambutan Nephelium Lappaceum a Potential Source Ofmentioning

confidence: 99%

Review: Potential Antioxidants from Tropical Plants

Ling

Palanisamy

2012

Food Industrial Processes - Methods and Equipment

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“…Nawawi et al (1999) tested the aqueous and methanolic leaf extracts of Plumbago zeylanica for anti-HSV-1 activity in the plaque reduction assay. Although different methods were used in that study, the methanol extracts of P. zeylanica at 91 ug/ml did not inhibit HSV-1 plaque formation in Vero cells.…”

Section: Resultsmentioning

confidence: 99%

The antiviral activity of six South African plants traditionally used against infections in ethnoveterinary medicine

Bagla

McGaw

Eloff

2012

Veterinary Microbiology

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Viral infections remain a major threat to humans and animals and there is a crucial need for new antiviral agents especially with the development of resistant viruses. The hexane, dichloromethane, acetone and methanol extracts of six plant species selected for their traditional use against infections were tested for in vitro antiviral activity against canine distemper virus (CDV), canine Parainfluenza virus-2 (CPIV-2), feline herpesvirus-1 (FHV-1) and lumpy skin disease virus (LSDV). All extracts were tested for their cytotoxicity using a colorimetric tetrazolium-based (MTT) assay and were tested for antiviral efficacy at concentrations below CC50 values on the various cell types used in the study. The antiviral activity of extracts was tested using virucidal and attachment assays. In the virucidal assay, extracts were incubated with virus prior to infection. The most potent inhibition was observed with the acetone and methanol extracts of Podocarpus henkelii against CDV and LSDV, which inhibited replication of the viruses by >75% at 3 ug/ml with selectivity index (SI) values ranging between 12 and 45. Excellent activity was also found with the hexane extracts of Plumbago zeylanica and Carissa edulis against CDV, with the extracts reducing viral-induced CPE by 50% and 75% respectively. The 2 hexane extract of Carissa edulis had moderate activity against FHV-1 with EC50 <70 ug/ml and SI value <2. Only the acetone extract of Podocarpus henkelii moderately inhibited replication of LSD virus in the attachment assay, with low activity in other extracts. Of the four extracts with significant antiviral activity, two were prepared from Podocarpus henkelii. Therefore, future work will focus on isolating and characterizing the substance(s) responsible for bioactivity in extracts of this species.

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Inhibitory effects of Indonesian medicinal plants on the infection of herpes simplex virus type 1

Cited by 65 publications

References 16 publications

Antiviral Effect of Guazuma ulmifolia and Stryphnodendron adstringens on Poliovirus and Bovine Herpesvirus

Antiviral Effect of Guazuma ulmifolia and Stryphnodendron adstringens on Poliovirus and Bovine Herpesvirus

Review: Potential Antioxidants from Tropical Plants

The antiviral activity of six South African plants traditionally used against infections in ethnoveterinary medicine

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