“…Moreover, PDGF is a most potent proliferative stimulator for HSCs (Pinzani and Marra, 2001;Friedman, 2003;Bataller and Brenner, 2005;Lotersztajn et al, 2005). In a previous study, it was reported that Ligusticum chuanxiong (L) exerted antiproliferative effects on PDGF-stimulated HSC-T6 cells, with modulation of cell cycle regulatory proteins conducive to apoptosis (Lin et al, 2006a). In the literature, glycyrrhizin, an active principle of licorice (Glycyrrhiza glabra, G), has been reported to abrogate ethanol-plus CCl 4 -induced hepatic fibrosis in rats, possibly by interfering with NFκB pathways (Wang et al, 1998).…”