Inhibitory effects of <i>Ligusticum chuanxiong</i> on the proliferation of rat hepatic stellate cells

Lin, Yun‐Lian; Lee, Ting-Fang; Huang, Yeh-Jeng; Huang, Yi-Tsau

doi:10.1111/j.1440-1746.2006.04326.x

Cited by 19 publications

(21 citation statements)

References 47 publications

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“…Moreover, PDGF is a most potent proliferative stimulator for HSCs (Pinzani and Marra, 2001;Friedman, 2003;Bataller and Brenner, 2005;Lotersztajn et al, 2005). In a previous study, it was reported that Ligusticum chuanxiong (L) exerted antiproliferative effects on PDGF-stimulated HSC-T6 cells, with modulation of cell cycle regulatory proteins conducive to apoptosis (Lin et al, 2006a). In the literature, glycyrrhizin, an active principle of licorice (Glycyrrhiza glabra, G), has been reported to abrogate ethanol-plus CCl 4 -induced hepatic fibrosis in rats, possibly by interfering with NFκB pathways (Wang et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

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Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats

Lin

Hsu²,

Chiu

et al. 2007

Phytotherapy Research

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Liver fibrosis has been characterized as chronic inflammatory processes involving multiple molecular pathogenetic pathways. This therapeutic study investigated whether a combination regimen of Salvia miltiorrhiza (S), Ligusticum chuanxiong (L) and Glycyrrhiza glabra (G) exerted in vivo antifibrotic effects on rats with hepatic fibrosis. Fibrosis was induced in rats by dimethylnitrosamine (DMN) administration for 4 weeks. Fibrotic rats were randomly assigned to one of the three groups: control, SLG (50 mg/kg) or silymarin (50 mg/kg), each given by gavage twice daily for 3 weeks starting 1 week after DMN injection. The results showed that fibrosis scores of livers from DMN-treated rats with SLG (1.13 ± ± ± ± ± 0.13) were significantly reduced in comparison with DMN-treated rats receiving vehicle (1.63 ± ± ± ± ± 0.18). Moreover, the hepatic collagen content of DMN rats was significantly reduced by either SLG or silymarin treatment. The double immunohistochemical staining results also showed that α α α α α-SMA positive cells with NFκ κ κ κ κB nuclear translocation were decreased in the fibrotic livers by SLG and silymarin treatments. The mRNA expression levels of TGF-β β β β β 1, α α α α α -SMA, collagen1α α α α α2, iNOS and ICAM-1 genes were attenuated by SLG and silymarin treatment. The results showed that SLG exerted antifibrotic effects in rats with DMN-induced hepatic fibrosis.

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Section: Discussionmentioning

confidence: 99%

“…Recently, the inhibitory effects of Ligusticum chuanxiong Hort. (L) on the proliferation of HSC-T6 cells have been reported (Lin et al, 2006a). Glycyrrhizin, an active compound of licorice (Glycyrrhiza glabra, G) has also been shown to abrogate hepatic fibrosis in rats (Wang et al, 1998).…”

Section: Introductionmentioning

confidence: 98%

Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats

Lin

Hsu²,

Chiu

et al. 2007

Phytotherapy Research

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“…JNK, p38, ERK1/2, and Smad2/3 phosphorylations were detected by immunoblotting. Total JNK, p38, ERK1/2, and Smad2/3 concentrations were used as respective internal controls for ensuring equal protein loading 21 …”

Section: Methodsmentioning

confidence: 99%

Effects of rhubarb on migration of rat hepatic stellate cells

Lin¹,

Wu²,

Huang³

2009

J of Gastro and Hepatol

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“…Inhibition of HSCs activation is one of the targets for anti‐fibrotic therapies (29). Our group has screened previously some medicinal herbs and isolated their active principles using PDGF‐BB‐induced proliferation or TGF‐β1‐induced migration models (30–33). In the present study, AB was used as a stimulator for HSCs migration, and the fractions of BS were screened.…”

Section: Discussionmentioning

confidence: 99%