Inhibitory Effects of<i>Glycyrrhiza glabra</i>and Its Major Constituent Glycyrrhizin on Inflammation-Associated Corneal Neovascularization

Shah, Syed Luqman; Wahid, Fazli; Khan, Naveed Ahmad; Farooq, Umar; Shah, Abdul Jabbar; Tareen, Shah; Ahmad, Fiaz; Khan, Taous

doi:10.1155/2018/8438101

Cited by 49 publications

(35 citation statements)

References 35 publications

(34 reference statements)

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“…Licorice has long been used for treatment of inflammatory, and the major bioactive compounds are flavonoids and triterpenoid saponins [24]. In this study, the anti‐inflammatory effects of extracts on LPS‐induced NO production in the RAW 264.7 macrophage cell were assessed (Figure 5).…”

Section: Resultsmentioning

confidence: 99%

Metabolomics study of different parts of licorice from different geographical origins and their anti‐inflammatory activities

Bai

Bao

Xiu

et al. 2020

J of Separation Science

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Glycyrrhiza uralensis Fisch., known as licorice, is one of the most famous traditional Chinese medicines. In this study, we perform a metabolome analysis using liquid chromatography-tandem mass spectrometry to assign bioactive components in different parts of licorice from different geographical origins in Gansu province of China. Sixteen potential biomarkers of taproots from different geographical origins were annotated, such as glycycoumarin, gancaonin Z, licoricone, and dihydroxy kanzonol H mainly exist in the sample of Jiuquan; neoliquiritin, 6 ′ -acetylliquiritin, licochalcone B, isolicoflavonol, glycyrol, and methylated uralenin mainly exist in Glycyrrhiza uralensis from Lanzhou; gancaonin L, uralenin, and glycybridin I mainly exist in licorice from Wuwei for the first time. K E Y W O R D Santi-inflammatory activity, geographical origin, licorice, metabolomics, traditional Chinese medicine

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Section: Resultsmentioning

confidence: 99%

Metabolomics study of different parts of licorice from different geographical origins and their anti‐inflammatory activities

Bai

Bao

Xiu

et al. 2020

J of Separation Science

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“…IP injection results in the presence of GL in tendon. Three hours after IP injection, significant amounts of GL, quantified using thin layer chromatography (62), are detected in mouse tendons. Amount of GL is minimal in mouse tendons without IP injection of GL, but there is 13-fold increase of GL in PT and 6.8-fold increase in AT.…”

Section: Supporting Informationmentioning

confidence: 99%

HMGB1 mediates the development of tendinopathy due to mechanical overloading

Zhao

Zhang

Nie

et al. 2019

Preprint

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15 Mechanical overloading is a major cause of tendinopathy, but the underlying pathogenesis of 16 tendinopathy is unclear. Here we report that high mobility group box1 (HMGB1) is released to 17 the tendon extracellular matrix and initiates an inflammatory cascade in response to mechanical 18 overloading in a mouse model. Moreover, administration of glycyrrhizin (GL), a naturally 19 occurring triterpene and a specific inhibitor of HMGB1, the tendon's inflammatory reactions.20 Also, while prolonged mechanical overloading in the form of long-term intensive treadmill 21 running induces Achilles tendinopathy in mice, administration of GL completely blocks the 22 tendinopathy development. Additionally, mechanical overloading of tendon cells in vitro induces 23 HMGB1 release to the extracellular milieu, thereby eliciting inflammatory and catabolic 24 responses as marked by increased production of prostaglandin E 2 (PGE 2 ) and matrix 25 metalloproteinase-3 (MMP-3) in tendon cells. Application of GL abolishes the cellular 26 inflammatory/catabolic responses. Collectively, these findings point to HMGB1 as a key 27 molecule that is responsible for the induction of tendinopathy due to mechanical overloading 28 placed on the tendon. 29 Keywords: Mechanical overloading, HMGB1, tendinopathy, tendon inflammation, tendon 30 degeneration, glycyrrhizin 31 32 Introduction 33 34Tendinopathy, a debilitating chronic tendon disorder, is manifested in clinical settings by 35 a combination of pain, swelling, compromised tendon structure, and rupture (1). Tendinopathy, 36 which involves tendon inflammation and degeneration, affects healthy individuals during their 37 active and productive years of life resulting in tremendous healthcare costs and economic impact 38 due to work-loss (2, 3). In particular, insertional tendinopathy, which is common in young 39 athletes, often occurs in the tendon proper proximal to the insertion into the heel bone and 40 accounts for about 20% of Achilles tendon disorders (4). It is well established that while normal 41 physiological loading is essential for tendon homeostasis, mechanical overloading induces the 42 development of tendinopathy, characterized by disorganized matrix, reduced numbers and 43 rounding of tendon cells, fibrocartilaginous change, and neovascularization (5, 6). A current 44 concept on the mechanisms of tendinopathy is that repetitive loading may lead to a 45 mechanobiological over-stimulation of tendon cells resulting in an imbalance between the 46 synthesis and breakdown of matrix proteins, especially collagen (7-9). The resulting mismatch is 47 a continuous loss of collagen in the tendon by repetitive loading with insufficient recovery time, 48 which initiates a catabolic degenerative response that leads to tendinopathy (6, 10). 50It is now recognized that inflammation is part of tendinopathy and could lead to tendon 51 degeneration that occurs at late stages of tendinopathy (11)(12)(13). Under excessive mechanical 52 loading, abnormal levels of proinflammatory mediators may be rel...

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“…In experimental and clinical studies, licorice has been shown to have a variety of pharmacological properties, including anti-in ammatory, antiviral, antibacterial, antioxidant, anti-diabetic, anti-asthmatic and anti-cancer activities, as well as immune regulation, protection of the stomach, the liver, the nerves, and the heart. [9][10][11][12][13][14][15] In recent years, some biochemical, molecular, and cellular mechanisms of licorice and its active components have also been con rmed by experimental studies. [16,17] licorice is one of the key herbs used in Chinese medicine.…”

Section: Rationalementioning

confidence: 97%

The efficacy and safety of compound glycyrrhizin combined with desloratadine in the treatment of chronic urticaria: protocol for a systematic review of randomized controlled trials

Wang¹,

Hu²,

Li³

et al. 2020

Preprint

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Background: Chronic urticaria (CU) is a common skin disease characterized by a short-term (<24 hours) spontaneous skin rash (urticaria) with or without angioedema that lasts longer than 6 weeks. CU is not life-threatening but has been shown to have a significant impact on the physical and mental health of patients. Because of chronic itching or physical discomfort in patients with CU, symptoms such as the repeated occurrence of red, swollen, itchy, anxiety, insomnia, and psychological stress are prone to occur. Whereas, there is no related systematic review and meta-analysis. Thus, this systematic review protocol aims to describe a systematic review and meta-analysis to testify the efficacy and safety of compound glycyrrhizin (CG) combined with desloratadine in the treatment of CU.Methods: Our systematic review will search all randomized controlled trials (RCTs) for CG combined with desloratadine in the treatment of CU, electronically and manually, regardless of publication status and language, until January 14, 2020. Databases include PubMed, EMBASE, Web of Science, Cochrane Controlled Trials Register (CENTRAL), China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), Chinese Science Journal Database (VIP Database) and Wanfang database. Other sources, including reference lists of identified publications and meeting minutes, will also be searched. Manually search for grey literature, including unpublished conference articles. The main outcomes contain the total effective rate, the urticaria activity score (UAS), Itching score, the chronic urticaria quality of life questionnaire (CU-Q2oL), or other validated symptom scores and the effective rate and adverse events from baseline to the end of studies. This study will provide a comprehensive review of the available evidence for the treatment of CU with this therapy. We will assess the risk of bias with the Cochrane Risk of Bias Tool, narratively synthesize the extracted data and conduct a meta-analysis of studies with similar characteristics. Two independent raters will screen articles and assess the risk of bias.Discussion: This study will provide a high-quality synthesis of the effects of compound glycyrrhizin (CG) combined with desloratadine in the treatment of CU. We hope that this review will give more convincing proof to assist clinicians during the decision-making process when dealing with CU.Systematic review registration: PROSPERO CRD42020165478

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Inhibitory Effects ofGlycyrrhiza glabraand Its Major Constituent Glycyrrhizin on Inflammation-Associated Corneal Neovascularization

Cited by 49 publications

References 35 publications

Metabolomics study of different parts of licorice from different geographical origins and their anti‐inflammatory activities

Metabolomics study of different parts of licorice from different geographical origins and their anti‐inflammatory activities

HMGB1 mediates the development of tendinopathy due to mechanical overloading

The efficacy and safety of compound glycyrrhizin combined with desloratadine in the treatment of chronic urticaria: protocol for a systematic review of randomized controlled trials

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