Inhibitory effects of<i>Aphanizomenon flos-aquae</i>constituents on human UDP-glucose dehydrogenase activity

Scoglio, Stefano; Curcio, Valeria Lo; Catalani, Simona; Palma, Francesco; Battistelli, Serafina; Benedetti, Serena

doi:10.3109/14756366.2016.1149478

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…For example, Scoglio et al . (2016) found that the former was 888 times more potent for inhibiting UDP-α-D-glucose 6-dehydrogenase activity [ 51 ]. This enzyme plays a role in the progression of prostate [ 52 ], breast [ 53 ], ovary [ 54 ], and epithelial cancers.…”

Section: Pharmacological Activities Of Pcbmentioning

confidence: 99%

C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19- induced Damage to the Nervous System

Pentón‐Rol

Marín‐Prida

McCarty³

2021

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: The edible cyanobacterium Spirulina platensis and its chief biliprotein C-Phycocyanin have shown protective activity in animal models of diverse human health diseases, often reflecting antioxidant and anti-inflammatory effects. The beneficial effects of C-Phycocyanin seem likely to be primarily attributable to its covalently attached chromophore Phycocyanobilin (PCB). Within cells, biliverdin is generated from free heme and it is subsequently reduced to bilirubin. Although bilirubin can function as an oxidant scavenger, its potent antioxidant activity reflects its ability to inactivate some isoforms of NADPH oxidase. Free bilirubin can also function as an agonist for the aryl hydrocarbon receptor (AhR); this may explain its ability to promote protective Treg activity in cellular and rodent models of inflammatory disease. AhR agonists also promote transcription of the gene coding for Nrf-2, and hence can up-regulate phase 2 induction of antioxidant enzymes such as HO-1. Hence, it is proposed that C-Phycocyanin/PCB chiefly exert their protective effects via inhibition of NADPH oxidase activity, as well as by AhR agonism that both induces Treg activity and up-regulates phase 2 induction. This simple model may explain their potent antioxidant/anti-inflammatory effects. Additionally, PCB might mimic biliverdin in activating anti-inflammatory signaling mediated by biliverdin reductase. This essay reviews recent research in which C-Phycocyanin and/or PCB, administered orally, parenterally, or intranasally, have achieved marked protective effects in rodent and cell culture models of Ischemic Stroke and Multiple Sclerosis, and suggests that these agents may likewise be protective for Alzheimer’s disease, Parkinson’s disease, and in COVID-19 and its neurological complications.

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Section: Pharmacological Activities Of Pcbmentioning

confidence: 99%

C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19- induced Damage to the Nervous System

Pentón‐Rol

Marín‐Prida

McCarty³

2021

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“…It is also rich in pigments such as carotene, beta-carotene, and chlorophylls [ 12 ]. Of particular relevance are its phycocyanins, which have a particular structure [ 13 ] and have proven to have significant antioxidant [ 14 ], anti-inflammatory [ 15 ], and antiproliferative [ 16 ] properties.…”

Section: Introductionmentioning

confidence: 99%

Effects of the Aphanizomenon flos-aquae Extract (Klamin®) on a Neurodegeneration Cellular Model

Nuzzo

Presti²,

Picone

et al. 2018

Oxidative Medicine and Cellular Longevity

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Cyanobacteria have been recognized as a source of bioactive molecules to be employed in nutraceuticals, pharmaceuticals, and functional foods. An extract of Aphanizomenon flos-aquae (AFA), commercialized as Klamin®, was subjected to chemical analysis to determine its compounds. The AFA extract Klamin® resulted to be nontoxic, also at high doses, when administered onto LAN5 neuronal cells. Its scavenging properties against ROS generation were evaluated by using DCFH-DA assay, and its mitochondrial protective role was determined by JC-1 and MitoSOX assays. Klamin® exerts a protective role against beta amyloid- (Aβ-) induced toxicity and against oxidative stress. Anti-inflammatory properties were demonstrated by NFβB nuclear localization and activation of IL-6 and IL-1β inflammatory cytokines through ELISA. Finally, by using thioflavin T (ThT) and fluorimetric measures, we found that Klamin® interferes with Aβ aggregation kinetics, supporting the formation of smaller and nontoxic structures compared to toxic Aβ aggregates alone. Altogether, these data indicate that the AFA extract may play a protective role against mechanisms leading to neurodegeneration.

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“…Similarly, the freshwater unicellular blue-green microalga Aphanizomenon flos-aquae , which grows spontaneously in Upper Klamath Lake in Oregon, USA, is also consumed as a nutrient-rich food source and for its health properties. Similar to the Arthrospira species, A. flos-aquae is an important source of the pigment C-phycocyanin; hence, demonstrating a strong antioxidant potential [ 32 , 33 ].…”

Section: Microalgaementioning

confidence: 99%

Microalgae Encapsulation Systems for Food, Pharmaceutical and Cosmetics Applications

2020

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Microalgae are microorganisms with a singular biochemical composition, including several biologically active compounds with proven pharmacological activities, such as anticancer, antioxidant and anti-inflammatory activities, among others. These properties make microalgae an interesting natural resource to be used as a functional ingredient, as well as in the prevention and treatment of diseases, or cosmetic formulations. Nevertheless, natural bioactives often possess inherent chemical instability and/or poor solubility, which are usually associated with low bioavailability. As such, their industrial potential as a health-promoting substance might be severely compromised. In this context, encapsulation systems are considered as a promising and emerging strategy to overcome these shortcomings due to the presence of a surrounding protective layer. Diverse systems have already been reported in the literature for natural bioactives, where some of them have been successfully applied to microalgae compounds. Therefore, this review focuses on exploring encapsulation systems for microalgae biomass, their extracts, or purified bioactives for food, pharmaceutical, and cosmetic purposes. Moreover, this work also covers the most common encapsulation techniques and types of coating materials used, along with the main findings regarding the beneficial effects of these systems.

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Inhibitory effects ofAphanizomenon flos-aquaeconstituents on human UDP-glucose dehydrogenase activity

Cited by 8 publications

References 26 publications

C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19- induced Damage to the Nervous System

C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19- induced Damage to the Nervous System

Effects of the Aphanizomenon flos-aquae Extract (Klamin®) on a Neurodegeneration Cellular Model

Microalgae Encapsulation Systems for Food, Pharmaceutical and Cosmetics Applications

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