Inhibitory Effects of Gold and Silver Nanoparticles on the Differentiation into Osteoclasts In Vitro

Lee, Daye; Ko, Wan‐Kyu; Kim, Seong Jun; Han, In Ho; Hong, Je Beom; Sheen, Seung Hun; Sohn, Seil

doi:10.3390/pharmaceutics13040462

Cited by 14 publications

(12 citation statements)

References 51 publications

(68 reference statements)

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“…Therefore, AuNPs can inhibit angiogenic activity, inhibit inflammation, or act as antioxidants, to protect cartilage tissue in arthritis. Studies have shown that AuNPs have the ability to inhibit osteoclasts and are one of the most effective nanoparticles for the treatment of bone tissue diseases [ 7 , 39 ].…”

Section: Bone Cartilage Disordermentioning

confidence: 99%

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as small as several nanometers, their physical and chemical properties vary with their size in nanometers. The surface area of a nano-sized gold surface has a special effect. Therefore, gold nanoparticles can, directly and indirectly, give rise to different biological activities. For example, if the surface of the gold is sulfided. Various substances have a strong chemical reactivity and are easy to combine with sulfhydryl groups; hence, nanogold is often used in biomedical testing, disease diagnosis, and gene detection. Nanogold is easy to bind to proteins, such as antibodies, enzymes, or cytokines. In fact, scientists use nanogold to bind special antibodies, as a tool for targeting cancer cells. Gold nanoparticles are also directly cytotoxic to cancer cells. For diseases caused by inflammation and oxidative damage, gold nanoparticles also have antioxidant and anti-inflammatory effects. Based on these unique properties, gold nanoparticles have become the most widely studied metal nanomaterials. Many recent studies have further demonstrated that gold nanoparticles are beneficial for humans, due to their functional pharmacological properties in a variety of diseases. The content of this review will be the application of gold nanoparticles in treating or diagnosing pressing diseases, such as cancers, retinopathy, neurological diseases, skin disorders, bowel diseases, bone cartilage disorders, cardiovascular diseases, infections, and metabolic syndrome. Gold nanoparticles have shown very obvious therapeutic and application potential.

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Section: Bone Cartilage Disordermentioning

confidence: 99%

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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“…The nGNP was prepared as previously described. 22 , 23 Detailed descriptions of the synthesis methods are provided in the Supporting Information S1 . The pGNP was prepared as described.…”

Section: Methodsmentioning

confidence: 99%

Transplantation of neuron‐inducing grafts embedding positively charged gold nanoparticles for the treatment of spinal cord injury

Kim

Han

et al. 2022

Bioengineering & Transla Med

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In this study, we aimed to investigate the recovery after traumatic spinal cord injury (SCI) by inducing cellular differentiation of transplanted neural stem cells (NSCs) into neurons. We dissociated NSCs from the spinal cords of Fisher 344 rat embryos. An injectable gel crosslinked with glycol chitosan and oxidized hyaluronate was used as a vehicle for NSC transplantation. The gel graft containing the NSC and positively charged gold nanoparticles (pGNP) was implanted into spinal cord lesions in Sprague–Dawley rats (NSC‐pGNP gel group). Cellular differentiation of grafted NSCs into neurons (stained with β‐tubulin III [also called Tuj1]) was significantly increased in the NSC‐pGNP gel group (***p < 0.001) compared to those of two control groups (NSC and NSC gel groups) in the SCI conditions. The NSC‐pGNP gel group showed the lowest differentiation into astrocytes (stained with glial fibrillary acidic protein). Regeneration of damaged axons (stained with biotinylated dextran amines) within the lesion was two‐fold higher in the NSC‐pGNP gel group than that in the NSC gel group. The highest locomotor scores were also found in the NSC‐pGNP gel group. These outcomes suggest that neuron‐inducing pGNP gel graft embedding embryonic spinal cord‐derived NSCs can be a useful type of stem cell therapy after SCI.

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“…The DPBS was replaced with fresh DPBS. The Beer–Lambert law is used to calculate the molar concentrations of the released GNP-UDCA from the CHA-GNP-UDCA gels. , …”

Section: Materials and Methodsmentioning

confidence: 99%

“…The Beer−Lambert law is used to calculate the molar concentrations of the released GNP-UDCA from the CHA-GNP-UDCA gels. 34,35 Cell Culture for PC12 and BMMs. PC12 cells were provided by American Type Culture Collection (ATCC, Manassas, VA, USA).…”

Section: ■ Introductionmentioning

confidence: 99%

Direct Injection of Hydrogels Embedding Gold Nanoparticles for Local Therapy after Spinal Cord Injury

Lee

Kim

et al. 2021

Biomacromolecules

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In this study, we created a hydrogel composed of glycol chitosan (gC) and oxidized hyaluronate (oHA). Gold nanoparticles (GNPs) were conjugated with ursodeoxycholic acid (UDCA). The GNP-UDCA complex was embedded into gC-oHA (CHA) hydrogels to form a CHA-GNP-UDCA gel. This CHA-GNP-UDCA gel was injected once into an epicenter of an injured region in SCI rats. Near-infrared (NIR) irradiation was then applied to the lesion as a means of local therapy. To optimize the viscosity for injection into a lesion, several volume ratios of gC and oHA were investigated using scanning electron microscopy and a rotating rheometer. The optimally synthesized CHA-GNP-UDCA gel under NIR irradiation suppressed the production of inflammatory cytokines in vitro. In addition, the optimized CHA-GNP-UDCA gel under NIR irradiation inhibited the cystic cavity of the lesion and significantly improved the hindlimb function. The production of inflammatory cytokines following SCI was significantly inhibited in the CHA-GNP-UDCA gel + NIR group. CHA-GNP-UDCA gels with NIR irradiation can therefore have therapeutic effects for those with spinal cord injuries.

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Inhibitory Effects of Gold and Silver Nanoparticles on the Differentiation into Osteoclasts In Vitro

Cited by 14 publications

References 51 publications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Transplantation of neuron‐inducing grafts embedding positively charged gold nanoparticles for the treatment of spinal cord injury

Direct Injection of Hydrogels Embedding Gold Nanoparticles for Local Therapy after Spinal Cord Injury

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