Inhibitory Effects of Ginsenoside Re Isolated from Ginseng Berry on Histamine and Cytokine Release in Human Mast Cells and Human Alveolar Epithelial Cells

Bae, Hye Min; Cho, Ok Sun; Kim, Shin‐Jeong; Im, Byung Ok; Cho, Soon Hyun; Lee, Sena; Kim, Myung-Gyou; Kim, Kyung Tack; Leem, Kang Hyun; Ko, Sung Kwon

doi:10.5142/jgr.2012.36.4.369

Cited by 19 publications

(16 citation statements)

References 21 publications

(18 reference statements)

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“…During inflammatory and allergic responses, mast cells activated by allergens release several inflammatory mediators, such as histamine, proinflammatory cytokines, and chemokines. Ginsenoside Rb1, Re, and Rh1 treatment significantly decreased histamine release from activated mast cells [28], [29], [30]. In addition, G-Rg5 and G-Rh3 suppressed degranulation of mast cells by decreasing histamine, TNF-α, and IL-6 in RBL-2H3 cells [31].…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg3 suppresses mast cell–mediated allergic inflammation via mitogen-activated protein kinase signaling pathway

Kee

Hong

2019

Journal of Ginseng Research

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Background Ginsenoside Rg3 (G-Rg3) is the major bioactive ingredient of Panax ginseng and has many pharmacological effects, including antiadipogenic, antiviral, and anticancer effects. However, the effect of G-Rg3 on mast cell–mediated allergic inflammation has not been investigated. Method The antiallergic effects of G-Rg3 on allergic inflammation were evaluated using the human and rat mast cell lines HMC-1 and RBL-2H3. Antiallergic effects of G-Rg3 were detected by measuring cyclic adenosine monophosphate (cAMP), detecting calcium influx, and using real-time reverse transcription polymerase chain reaction, enzyme-linked immunosorbent assay, Western blotting, and in vivo experiments. Results G-Rg3 decreased histamine release from activated mast cells by enhancing cAMP levels and calcium influx. Proinflammatory cytokine production was suppressed by G-Rg3 treatment via regulation of the mitogen-activated protein kinases/nuclear factor-kappa B and receptor-interacting protein kinase 2 (RIP2)/caspase-1 signaling pathway in mast cells. Moreover, G-Rg3 protected mice against the IgE-mediated passive cutaneous anaphylaxis reaction and compound 48/80-induced anaphylactic shock. Conclusion G-Rg3 may serve as an alternative therapeutic agent for improving allergic inflammatory disorders.

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Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg3 suppresses mast cell–mediated allergic inflammation via mitogen-activated protein kinase signaling pathway

Kee

Hong

2019

Journal of Ginseng Research

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“…Ginsenoside is the biochemically and pharmacologically active ingredient in ginseng [ 26 ]. Pharmacologically, ginsenoside acts like an anti-diabetic and anti-hypertensive, promotes liver function, cures hangovers, has an anti-fatigue, antioxidant, and anti-inflammatory activity, promotes protein synthesis, and has an immuno-enhancing effect [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

SGL 121 Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism Through AMPK Signaling Pathway

Kim

Chang

Jeon

et al. 2020

IJMS

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A ginsenoside F2-enhanced mixture (SGL 121) increases the content of ginsenoside F2 by biotransformation. In the present study, we investigated the effect of SGL 121 on nonalcoholic fatty liver disease (NAFLD) in vitro and in vivo. High-fat, high-carbohydrate-diet (HFHC)-fed mice were administered SGL 121 for 12 weeks to assess its effect on improving NAFLD. In HepG2 cells, SGL 121 acted as an antioxidant, a hepatoprotectant, and had an anti-lipogenic effect. In NAFLD mice, SGL 121 significantly improved body fat mass; levels of hepatic triglyceride (TG), hepatic malondialdehyde (MDA), serum total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL); and activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In HepG2 cells, induced by oxidative stress, SGL 121 increased cytoprotection, inhibited reactive oxygen species (ROS) production, and increased antioxidant enzyme activity. SGL 121 activated the Nrf2/HO-1 signaling pathway and improved lipid accumulation induced by free fatty acids (FFA). Sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS) expression was significantly reduced in NAFLD-induced liver and HepG2 cells treated with SGL 121. Moreover, SGL 121 activated adenosine monophosphate-activated protein kinase (AMPK), which plays an important role in the regulation of lipid metabolism. The effect of SGL 121 on the improvement of NAFLD seems to be related to its antioxidant effects and activation of AMPK. In conclusion, SGL 121 can be potentially used for the treatment of NAFLD.

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“…It was also reported that other effects of ginseng berries include such physiologically activating functions as antidiabetic [2], antiobese [2], Antisenility [3], antistress [4], antiallergic [5], and anticancer effects [6].…”

mentioning

confidence: 99%

Changes in ginsenoside composition of ginseng berry extracts after a microwave and vinegar process

Kim

Ko³

2013

Journal of Ginseng Research

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Inhibitory Effects of Ginsenoside Re Isolated from Ginseng Berry on Histamine and Cytokine Release in Human Mast Cells and Human Alveolar Epithelial Cells

Abstract: The berry of Panax ginseng significantly inhibited the histamine releases at the concentration of 30 μg/mL (p<0.05) and 10 μg/mL (p<0.01). The ginsenoside Re from ginseng berry was found out to have a potent effect in the experiment of histamin and cytokine release.

Cited by 19 publications

References 21 publications

Ginsenoside Rg3 suppresses mast cell–mediated allergic inflammation via mitogen-activated protein kinase signaling pathway

Ginsenoside Rg3 suppresses mast cell–mediated allergic inflammation via mitogen-activated protein kinase signaling pathway

SGL 121 Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism Through AMPK Signaling Pathway

Changes in ginsenoside composition of ginseng berry extracts after a microwave and vinegar process

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