Inhibitory effects of genistein on metastasis of human hepatocellular carcinoma

Gu, Yan; Zhu, C.C.; Dai, Yalei; Zhong, Qiang; Sun, Bo

doi:10.3748/wjg.15.4952

Cited by 44 publications

(27 citation statements)

References 27 publications

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“…Genistein also inhibited the activation of focal adhesion kinase [154,155] and p38 mitogen-activated protein kinase-heat shock protein 27 (HSP27) pathway [155], which were shown to regulate cancer cell detachment and invasion, respectively.…”

Section: Isoflavones From Soymentioning

confidence: 98%

Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis

Shu

Cheung

Khor

et al. 2010

Cancer Metastasis Rev

212

152

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Carcinogenesis is a multi-step process which could be prevented by phytochemicals. Phytochemicals from dietary plants and other plant sources such as herbs are becoming increasingly important sources of anticancer drugs or compounds for cancer chemoprevention or adjuvant chemotherapy. Phytochemicals can prevent cancer initiation, promotion, and progression by exerting anti-inflammatory and anti-oxidative stress effects which are mediated by integrated Nrf2, NF-kappaB, and AP-1 signaling pathways. In addition, phytochemicals from herbal medicinal plants and/or some dietary plants developed in recent years have been shown to induce apoptosis in cancer cells and inhibition of tumor growth in vivo. In advanced tumors, a series of changes involving critical signaling molecules that would drive tumor cells undergoing epithelial-mesenchymal transition and becoming invasive. In this review, we will discuss the potential molecular targets and signaling pathways that mediate tumor onset and metastasis. In addition, we will shed light on some of the phytochemicals that are capable of targeting these signaling pathways which would make them potentially applicable to cancer chemoprevention, treatment and control of cancer progression.

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Section: Isoflavones From Soymentioning

confidence: 98%

Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis

Shu

Cheung

Khor

et al. 2010

Cancer Metastasis Rev

212

152

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“…It induces apoptosis in the following hepatocellular carcinoma cells (HCCs): Bel 7402 (104), HuH-7 (105), Hep3B (106), and HepG2 (107). Genistein may affect HCC progression as a result of its activity on apoptosis and cell cycle regulation (104,108), acting as a promising inhibitor of the metastatic process in HCCs. In fact, genistein has been shown to inhibit the migration of 3 cell lines (HepG2, SMMC-7721, and Bel-7402 cells) (109).…”

Section: Genistein and Cancermentioning

confidence: 99%

Genistein and Cancer: Current Status, Challenges, and Future Directions

Spagnuolo

Russo

Orhan

et al. 2015

Advances in Nutrition

413

246

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Primary prevention through lifestyle interventions is a cost-effective alternative for preventing a large burden of chronic and degenerative diseases, including cancer, which is one of the leading causes of morbidity and mortality worldwide. In the past decade, epidemiologic and preclinical evidence suggested that polyphenolic phytochemicals present in many plant foods possess chemopreventive properties against several cancer forms. Thus, there has been increasing interest in the potential cancer chemopreventive agents obtained from natural sources, such as polyphenols, that may represent a new, affordable approach to curb the increasing burden of cancer throughout the world. Several epidemiologic studies showed a relation between a soy-rich diet and cancer prevention, which was attributed to the presence of a phenolic compound, genistein, present in soy-based foods. Genistein acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis. Targeting caspases, B cell lymphoma 2 (Bcl-2)-associated X protein (Bax), Bcl-2, kinesin-like protein 20A (KIF20A), extracellular signal-regulated kinase 1/2 (ERK1/2), nuclear transcription factor κB (NF-κB), mitogen-activated protein kinase (MAPK), inhibitor of NF-κB (IκB), Wingless and integration 1 β-catenin (Wnt/β-catenin), and phosphoinositide 3 kinase/Akt (PI3K/Akt) signaling pathways may act as the molecular mechanisms of the anticancer, therapeutic effects of genistein. Genistein also shows synergistic behavior with well-known anticancer drugs, such as adriamycin, docetaxel, and tamoxifen, suggesting a potential role in combination therapy. This review critically analyzes the available literature on the therapeutic role of genistein on different types of cancer, focusing on its chemical features, plant food sources, bioavailability, and safety.

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“…Genistein exhibits significant anticarcinogenic effects on breast cancer, prostate cancer and other tumors (Lamartiniere, 2002;Li et al, 2005;Lakshman et al, 2008). It inhibits the proliferation of HCC cells (Yeh et al, 2007) and liver cancer metastasis (Gu et al, 2009). Moreover, genistein has been proved to be a relatively low toxicity agent (D'Anna et al, 2007), which makes it a promising drug in treating HCC.…”

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confidence: 99%