Inhibitory Effects of Electrically Activated Silver Material on Cutaneous Wound Bacteria

Falcone, Alfred E.; Spadaro, Joseph A.

doi:10.1097/00006534-198603000-00022

Cited by 23 publications

(11 citation statements)

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“…Topical antibiotic agents should first be applied directly to the patient's dressings before application to the burn wound to prevent contamination of the agent's container by burn wound flora. Table 4 outlines the most widely used topical antimicrobial agents and new silver nanocrystalline dressings that are based on the bactericidal properties of the silver ion (134,189,298). The inhibitory action of silver is due to its strong interaction with thiol groups present in the respiratory enzymes in the bacterial cell (237,238).…”

Section: Topical Antimicrobial Therapymentioning

confidence: 99%

Burn Wound Infections

Church

Elsayed

Reid³

et al. 2006

Clin Microbiol Rev

1,602

1,345

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SUMMARYBurns are one of the most common and devastating forms of trauma. Patients with serious thermal injury require immediate specialized care in order to minimize morbidity and mortality. Significant thermal injuries induce a state of immunosuppression that predisposes burn patients to infectious complications. A current summary of the classifications of burn wound infections, including their diagnosis, treatment, and prevention, is given. Early excision of the eschar has substantially decreased the incidence of invasive burn wound infection and secondary sepsis, but most deaths in severely burn-injured patients are still due to burn wound sepsis or complications due to inhalation injury. Burn patients are also at risk for developing sepsis secondary to pneumonia, catheter-related infections, and suppurative thrombophlebitis. The introduction of silver-impregnated devices (e.g., central lines and Foley urinary catheters) may reduce the incidence of nosocomial infections due to prolonged placement of these devices. Improved outcomes for severely burned patients have been attributed to medical advances in fluid resuscitation, nutritional support, pulmonary and burn wound care, and infection control practices.

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Section: Topical Antimicrobial Therapymentioning

confidence: 99%

Burn Wound Infections

Church

Elsayed

Reid³

et al. 2006

Clin Microbiol Rev

1,602

1,345

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“…More recent attempts to prevent the development of nosocomial infections related to medical devices (urinary catheters, CV-catheters) have also utilized silver-releasing materials and the electrically generated silver coating [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] . These include the Vita cuff, which is made of silver-protein impregnated collagen and is intended to provide a barrier to infection at the entry site of vascular access devices 56 .…”

Section: Silver-containing Biomedical Polymersmentioning

confidence: 99%

Novel Strategies to Prevent Catheter-Associated Infections in Oncology Patients

Schierholz¹,

Beuth²,

Rump³

et al. 2001

Journal of Chemotherapy

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Aggressive cytotoxic treatment of cancer contributes to the growing number of life-threatening infections. Vascular catheters create predominant risks for staphylococcal, enterococcal and candida blood stream infections. Although the contaminating microorganisms may be few in number, the altered host immune response in the presence of such implants as well as disease-associated immunosuppression implies that even small bacterial counts have to be regarded as highly virulent species. Diagnosis of catheter-related infection (CRI) remains difficult before withdrawal of the suspected catheter. Positive culture of catheter surface, lumen and hub and positive peripheral blood probes (paired quantitative blood culture) are predictive for catheter related bacteremia (CRB). Diligent catheter care and effective antimicrobial catheters may reduce prolonged hospital stay, increased morbidity or mortality and serious economical consequences. The most promising approach features the incorporation of antimicrobial drugs into the polymer matrices that entrap but do not bind the drugs, allowing for extended release. For the efficacious prevention of colonization in the microenvironment of the implantable device the concentration of the antimicrobial substances must exceed usual antibiotic concentrations by a thousand-fold. This is the desired effect--high concentration near the device surface and very low systemic concentration. Incorporation of antimicrobials in the bulk material that constitutes a device can be effective as shown in several in vitro and in vivo studies. In the future, modification of both short-term and long-term catheters by biofilm-active antimicrobials creating slow delivery systems may provide an effective method to protect patients from nosocomial infection in oncology.

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“…The use of silver-impregnated nylon cloths with an applied weak direct current results in electrochemical oxidation of the silver particles with periodic or sustained release of the ion [39,41]. This method increases silver penetration and is active against a wide variety of pathogens [39,41,42].…”

Section: Topical Application For Burnsmentioning

confidence: 99%

“…This method increases silver penetration and is active against a wide variety of pathogens [39,41,42]. In infected burn animal models, the application of a current to a silvercoated nylon surface anode achieved greater survival than in animals treated without current, whereas both were superior to uncoated nylon either with or without applied current [43].…”

Section: Topical Application For Burnsmentioning

confidence: 99%

Use of Silver in the Prevention and Treatment of Infections: Silver Review

Politano

Campbell

Rosenberger

et al. 2013

Surgical Infections

167

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Background: The use of silver for the treatment of various maladies or to prevent the transmission of infection dates back to at least 4000 b.c.e. Medical applications are documented in the literature throughout the 17th and 18th centuries. The bactericidal activity of silver is well established. Silver nitrate was used topically throughout the 1800s for the treatment of burns, ulcerations, and infected wounds, and although its use declined after World War II and the advent of antibiotics, Fox revitalized its use in the form of silver sulfadiazine in 1968. Method: Review of the pertinent English-language literature. Results: Since Fox's work, the use of topical silver to reduce bacterial burden and promote healing has been investigated in the setting of chronic wounds and ulcers, post-operative incision dressings, blood and urinary catheter designs, endotracheal tubes, orthopedic devices, vascular prostheses, and the sewing ring of prosthetic heart valves. The beneficial effects of silver in reducing or preventing infection have been seen in the topical treatment of burns and chronic wounds and in its use as a coating for many medical devices. However, silver has been unsuccessful in certain applications, such as the Silzone heart valve. In other settings, such as orthopedic hardware coatings, its benefit remains unproved. Conclusion: Silver remains a reasonable addition to the armamentarium against infection and has relatively few side effects. However, one should weigh the benefits of silver-containing products against the known side effects and the other options available for the intended purpose when selecting the most appropriate therapy.

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Inhibitory Effects of Electrically Activated Silver Material on Cutaneous Wound Bacteria

Cited by 23 publications

References 0 publications

Burn Wound Infections

Burn Wound Infections

Novel Strategies to Prevent Catheter-Associated Infections in Oncology Patients

Use of Silver in the Prevention and Treatment of Infections: Silver Review

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