Inhibitory Effects of Cabbage Juice and Cabbage-Mixed Juice on the Growth of AGS Human Gastric Cancer Cells and on HCl-Ethanol Induced Gastritis in Rats

Abstract

This study determined the effects of cabbage juice and cabbage-mixed juices on the growth of AGS human gastric cancer cells and their anti-gastritic effects on HCl-ethanol induced gastritis in SD rats. Cabbage juice showed the highest growth inhibition on AGS gastric cancer cells in vitro (42%), compared with chlorella (20%) and kale juice (21%). However, cabbage-chlorella and cabbage-kale juice mixtures (at a 7:3 ratio) showed synergistic effects (57% and 65% inhibitory effects, respectively) on the gastric cancer cells. Inflammatory genes (iNOS, COX-2, TNF-α and IL-1β) were significantly down-regulated in the mixed juices. Tests of DPPH radical scavenging activity and acid-neutralizing capacity with the mixed juices also showed this trend, as cabbage-chlorella and cabbage-kale mixed juices showed synergistic effects compared to cabbage juice alone. The inhibition rate of acute gastritis induced by HCl-ethanol in rats was 46% with high amounts of cabbage (CH; 800 mg/kg), 71% with high amounts of cabbage and chlorella (CChH; 800 mg/kg), 74% with high amounts of cabbage and kale (CKH; 800 mg/kg), and 75% with cimetidine (positive control) compared with the control.In addition, rates with CChH and CKH showed decreasing gastric secretions with increasing pH. These results show that cabbage juice and cabbage-mixed juices, especially with chlorella or kale, exhibit remarkable anti-gastritic effects and can be administered for a long period for the prevention and treatment of gastric cancer and gastritis.

Mitigation of Gastric Damage Using Cinnamomum cassia Extract: Network Pharmacological Analysis of Active Compounds and Protection Effects in Rats

“…The rats were given ad libitum access to feed and water. In experiments for inducing gastric ulcers, mice were administered their respective C. cassia extract article (except for the gastritis control groups, which were administered a carboxymethyl cellulose sodium salt (CMC) solution) after 48 h of feed deprivation, and gastric damage was induced by administering indomethacin (80 mg/kg) [ 51 , 52 ], ethanol (100% EtOH), or an ethanol-HCl (150 mM HCl in 70% EtOH) [ 11 , 12 ] 30 min after the pre-treatment. Five hours later, all animals were sacrificed, and their stomachs were extracted for experimental purposes.…”

“…Therefore, the development of therapeutic agents for gastritis and gastric ulcers using natural products, with no side effects, is in progress. Several studies have recently reported the protective effects of natural products without side effects and toxicity against gastric mucosal damage using several animal models [ 9 , 11 , 12 ].…”

Protective effects of a standardized extract (HemoHIM) using indomethacin- and ethanol/HCl-induced gastric mucosal injury models

“…2015) and inhibitory effects of cabbage juice on EtOH-HCl induced gastritis in rats (Hong et al. 2013) were reported.…”

“…In addition, EtOH/HCl causes severe damage and necrotic lesions to the gastric mucosa (Hong et al. 2013). The animal models of gastric injuries induced by indomethacin and EtOH/HCl have been widely used in studies to evaluate the protective effects of herbal products against gastritis and gastric ulcers.…”

Influence of Fertilization Treatment using Organic Amendment based on Soil Testing on Plant Growth and Nutrient use Efficiency in Cabbage

“…가되었으나, 반면에 과도한 퇴비시용은 질산염 [2], 양분의 지 하수로의 용탈 [3] 및 이로 인한 지하수 오염 [4] [7]. 양배추는 간 보호 및 간기능 개선 [8], 항산화 활성 [9], 항위염 [10] 등의 효 과로 인해 케이크 [11], 떡 [12], 양배추 즙 [13] ---------------------------------------(%) ---------------------------------------…”