Inhibitory effects of biseokeaniamide A against lipopolysaccharide-induced signal transduction

Ohno, Osamu; Terasaki, Takuro; Sano, Takuya; Yuki, Hitomi; Miyamoto, Junichiro; Matsuno, Kenji

doi:10.1016/j.bmcl.2020.127069

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…Thus, it is hard to confirm the specific information of extraction sources and active compounds. The underlying mechanisms from in vitro and in vivo of MBS as therapeutic agents for periodontitis were demonstrated by only seven articles (12.5% of the number of articles about MBS for periodontitis treatment) (Batool et al, 2020;Batool et al, 2022;Kang et al, 2021;Kao et al, 2021;Kim et al, 2019b;Kim et al, 2021a;Ohno et al, 2020). Finally, few clinical studies (8 articles) were conducted to confirm the safety and therapeutic efficacy of MBS.…”

Section: Discussionmentioning

confidence: 99%

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Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

Lee¹,

Kwon²,

Jung³

2023

Fish Aquat Sci

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Marine bioactive substances (MBS), such as phlorotannins, collagens, peptides, sterols, and polysaccharides, are increasing attention as therapeutic agents for several diseases due to their pharmacological effects. Previous studies have demonstrated the biological activities of MBS including antibacterial, anticoagulant, antidiabetic, antimicrobial, anti-inflammatory activities. Among numerous human diseases, periodontitis is one of the high-prevalence inflammatory diseases in the world. To treat periodontitis, several surgeries (bone grafting, flap surgery, and soft tissue graft) are usually used. However, the surgery for patients with chronic periodontitis induces several side effects, including additional inflammatory responses at the operated site, chronic wound healing, and secondary surgery. Therefore, this review assessed the most recent trends in MBS using Google Scholar, PubMed, and Web of Science search engines to develop marine-derived therapeutic agents for periodontitis. Further, we summarized the current applications and therapeutic potential of MBS to serve as a reference for developing novel technologies applied to MBS against periodontitis treatment.

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Section: Discussionmentioning

confidence: 99%

“…A study confirmed that biseokeaniamide A, isolated Okeania sp., exhibits anti-inflammatory activity on LPS-stimulated RAW 264.7 (Ohno et al, 2020). Biseokeaniamide A inhibited NO production and IL-1β expression in LPS-stimulated RAW 264.7.…”

Section: Fisheries and Aquatic Sciencesmentioning

confidence: 94%

Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

Lee¹,

Kwon²,

Jung³

2023

Fish Aquat Sci

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“…These compounds include the highly cytotoxic compounds, bisebromoamide (65) and aurilide-class of compounds (e.g., 66), antiinfective molecules, almiramides (e.g., 67) and janadolide (68), anti-inflammatory molecule, biseokeaniamide A (69) as well as cannabimimetics/CNS modulatory agents, such as mooreamide A and serinolamides (e.g., 70) (Figure 13) [145][146][147][148][149][150][151][152][153]. Further biological evaluation and synthesis of analogues have also been initiated for some of these compounds [154][155][156][157][158][159]. The search for novel bioactive cyanobacterial compounds has also been expedited with recent advances in genomic and metabolomics techniques, e.g., the integrated use of mass spectrometric based molecular networking and genomic approaches [160,161].…”

Section: Discussionmentioning

confidence: 99%

Marine Cyanobacteria: A Source of Lead Compounds and their Clinically-Relevant Molecular Targets

Tan

Phyo

2020

Molecules

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The prokaryotic filamentous marine cyanobacteria are photosynthetic microbes that are found in diverse marine habitats, ranging from epiphytic to endolithic communities. Their successful colonization in nature is largely attributed to genetic diversity as well as the production of ecologically important natural products. These cyanobacterial natural products are also a source of potential drug leads for the development of therapeutic agents used in the treatment of diseases, such as cancer, parasitic infections and inflammation. Major sources of these biomedically important natural compounds are found predominately from marine cyanobacterial orders Oscillatoriales, Nostocales, Chroococcales and Synechococcales. Moreover, technological advances in genomic and metabolomics approaches, such as mass spectrometry and NMR spectroscopy, revealed that marine cyanobacteria are a treasure trove of structurally unique natural products. The high potency of a number of natural products are due to their specific interference with validated drug targets, such as proteasomes, proteases, histone deacetylases, microtubules, actin filaments and membrane receptors/channels. In this review, the chemistry and biology of selected potent cyanobacterial compounds as well as their synthetic analogues are presented based on their molecular targets. These molecules are discussed to reflect current research trends in drug discovery from marine cyanobacterial natural products.

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“…Furthermore, 377 displayed significant cytotoxicity and induced apoptosis in HeLa cells and activated caspase 3 dose-dependently (Iwasaki et al 2017). Compound 376 had anti-inflammatory effects through selective inhibition of LPS-induced signal transduction (Ohno et al 2020). Kalkitoxin (379), a hybrid NRPS/PKS lipopeptide from L. majuscula, proved to be a potent anti-inflammation metabolite.…”

Section: Peptidesmentioning

confidence: 99%

The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987–2020)

Hai

Wei

Wang

et al. 2021

Mar Life Sci Technol

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Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery. The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor, antibiotic, anti-inflammatory and antiviral activities. We reviewed all the 484 sulfur-containing natural products (non-sulfated) isolated from marine microorganisms, of which 59.9% are thioethers, 29.8% are thiazole/thiazoline-containing compounds and 10.3% are sulfoxides, sulfones, thioesters and many others. A selection of 133 compounds was further discussed on their structure–activity relationships, mechanisms of action, biosynthesis, and druggability. This is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987, when the first one was reported, to December 2020.

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Inhibitory effects of biseokeaniamide A against lipopolysaccharide-induced signal transduction

Cited by 8 publications

References 21 publications

Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

Therapeutic effect of marine bioactive substances against periodontitis based on in vitro, in vivo, and clinical studies

Marine Cyanobacteria: A Source of Lead Compounds and their Clinically-Relevant Molecular Targets

The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987–2020)

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