Inhibitory Effects of Aqueous Extract of Bridelia ferruginea Stem Bark on Iron (II) Sulphate - Induced Oxidative Stress in Brain and Liver of Albino Wistar Rats

In vitro Studies on Antioxidant Potential of Aqueous Extract of Bridelia ferruginea Stem Bark in Brain and Liver of Wistar-albino Rats using Sodium Nitroprusside as Pro-oxidant

“…According to the results of this study, the aqueous extract of Bridelia ferruginea stem bark showed ability to inhibit TBARS formation in the liver and brain homogenates used. This agrees with the results of [1], when the aqueous extract of Bridelia ferruginea stem bark was used to inhibit TBARS formation induced by iron (II) sulphate. It also agrees with the work of [18], where the ethanolic extract of Bridelia ferruginea stem bark is discovered to have an effective TBARS inhibiting ability in the liver and brain of albino rats.…”

“…The inhibition of TBARS by the aqueous extract of Bridelia ferruginea stem bark is an indication of the antioxidant potential of the plant extract [1]. The protection offered by the aqueous extract of Bridelia ferruginea on tissues (liver and brain) induced with lipid peroxidation in this study is most likely due to its rich phytochemical constituents, such as flavonoids and alkaloids [9].…”

“…All over the world, several hundreds of plants are good sources of medicinal agents and are used in traditional medicine for a large number of different purposes [1][2][3]. As a result, plants are one of the bedrocks for modern medicines [4].…”

“…In humans, oxidative stress is thought to be involved in the development of many diseases or may make worse their symptoms. These include cancer, Parkinson's disease, Alzheimer's disease, atherosclerosis, heart failure and chronic fatigue syndrome [1]. An overdose of the analgesic paracetamol (acetaminophen) can cause fatal damage to the liver, partly through its production of reactive oxygen species [14,15].…”

“…An antioxidant is a molecule that inhibits the oxidation of other molecules. As oxidative stress appears to be an important part of many human diseases, the use of antioxidants in pharmacology is been intensively studied, particularly as treatments for stroke and neurodegenerative diseases [1]. Antioxidants are widely used in dietary supplements and have been investigated for the prevention of diseases such as cancer and coronary heart disease.…”