Inhibitory effects of adrenocorticotrophin or corticosterone on progesterone secretion during mid-pregnancy in rats

Katô, Hiroshi; Nanjo, K; Numa, Fumitaka; Nakamura, Yoshiko; Ueda, Kaho; Inoguchi, Hiroyuki; Torigoe, T

doi:10.1530/jrf.0.0830867

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…This assumption is consistent with the fact that the circulating levels of corticosterone are almost the same in both groups (Dupouy, Coffigny & Magre, 1975), while serum progesterone levels are significantly higher in the FC group (Table 1) (Kato et al 1988). Oestrogen, which overcame the effects of corticosterone, is present in higher concentration in the CL of FC rats (Table 1) and may protect the CL against luteolytic factors.…”

Section: Discussionsupporting

confidence: 83%

“…Involvement of the pituitary-adrenal axis in the maintenance of preg¬ nancy has also been demonstrated in several species (Velardo, 1957;Yang, Yang & Lin, 1969;Christian, 1971;Kittinger, Gutierrez-Cernosek, Cernosek & Pasley, 1980;Rosa & Wagner, 1981;Hellar & de Nicola, 1983). Recently, Kato, Nanjo, Numa et al (1988) demonstrated that adrenocorticotrophin (ACTH) and corticosterone inhibit progesterone secretion during mid-pregnancy in rats. These authors also suggested that the inhibitory effect of ACTH or corticosterone might be eliminated by placental hor¬ mones, because inhibition was apparent only in rats bearing single conceptus but not in those bearing a full complement of conceptuses.…”

Section: Introductionmentioning

confidence: 99%

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Different mechanisms for the inhibition of progesterone secretion by ACTH and corticosterone in pregnant rats

Sugino

Tamura²,

Nakamura³

et al. 1991

Journal of Endocrinology

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The present study investigated possible sites through which ACTH or corticosterone inhibit progesterone secretion in pregnant rats, and the role of placental factors in blocking the inhibitory effect. The number of conceptuses was adjusted to one (IC group) or more than ten (FC group) on day 7 of pregnancy by aspirating the desired number. Serum concentrations of progesterone, testosterone and oestradiol were significantly (P less than 0.01) lower on day 15 in the 1C group than in the FC group. Corpora lutea (CL) obtained on day 15 were incubated for 6 h with corticosterone or ACTH. Corticosterone (1 mumol/l) significantly (P less than 0.05) inhibited progesterone secretion in the 1C group but not in the FC group. The inhibitory effect of corticosterone in the 1C group was completely blocked by co-addition of 1 mumol testosterone/l or 1 mumol oestradiol/l but not by 1 mumol dihydrotestosterone/l. ACTH (1 microgram/l-1 mg/l) had no direct effect on progesterone secretion in either the 1C or the FC groups, although ACTH apparently decreases progesterone secretion in vivo. Placentae obtained from rats of the FC group on day 15 were incubated for 24 h with or without ACTH (1 mg/l). The supernatant after placental incubation without ACTH significantly (P less than 0.01) increased progesterone secretion by the CL in both the 1C and FC groups, and also eliminated the inhibitory effect of corticosterone in the 1C group. The supernatant after placental incubation with ACTH also increased progesterone secretion in the FC group as effectively as the supernatant from the control incubation, but it had no effect in the 1C group.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Different mechanisms for the inhibition of progesterone secretion by ACTH and corticosterone in pregnant rats

Sugino

Tamura²,

Nakamura³

et al. 1991

Journal of Endocrinology

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“…However, in the present study, ovulation, indicated by the presence of newly formed CLs on the morning of estrus, was not blocked even with the higher DEX doses, whereas direct effects on the CL were observed even with the lowest DEX doses. In previous studies, GCs have inhibited progesterone secretion in other experimental models in the rat [10,12] or in other species [11]. Different mechanisms, including direct effects on the CL [12], have been proposed.…”

Section: Discussionmentioning

confidence: 99%

“…Pathological conditions such as Cushing's syndrome and physical or psychological stress adversely affect fertility [9]. Moreover, GCs inhibit progesterone secretion [10][11][12], although stimulatory effects have been reported in hypophysectomized rats [13]. Glucocorticoid receptors are expressed in ovarian cells [13,14], which implies the potential for direct actions of GCs in the ovary.…”

Section: Introductionmentioning

confidence: 99%

Selective Apoptosis of Luteal Endothelial Cells in Dexamethasone-Treated Rats Leads to Ischemic Necrosis of Luteal Tissue1

Gaytán¹,

Morales²,

Bellido³

et al. 2002

Biology of Reproduction

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In infertile cycles in rats, the corpus luteum (CL) ceases producing progesterone in about 2 days and is eliminated by structural luteolysis. Glucocorticoids disrupt the ovarian cycle and interfere with structural luteolysis. We studied the effects of the glucocorticoid dexamethasone (DEX) on rat luteolysis. Cycling rats were treated during 3 days (from estrus to diestrus) with different doses (0.025, 0.1, 0.4, and 1 mg/rat) of DEX or vehicle. DEX-treated rats showed a necrotic pattern of cell death, affecting exclusively the last generation of regressing CLs. In these animals, selective apoptosis of luteal endothelial cells, detected by both morphological characteristics and TUNEL assay, was observed on the morning of proestrus and was followed by necrosis of the luteal tissue. These effects were dose related. With the lowest DEX doses (0.025 and 0.1 mg), only some of the animals were affected and showed smaller necrotic areas in CLs. The deleterious effects of DEX on endothelial cells were in keeping with the immunohistochemical localization of glucocorticoid receptors in the endothelial cells of the last CL generation. The results of this study strongly suggest that DEX-induced selective apoptosis of endothelial cells leads to ischemic necrosis of the luteal tissue and raises the possibility that actions on endothelial cells may be underlying glucocorticoid-induced effects on the ovary.

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Plasma progesterone response following ACTH administration during mid-gestation in the pregnant Brahman heifer

et al. 2005

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Inhibitory effects of adrenocorticotrophin or corticosterone on progesterone secretion during mid-pregnancy in rats

Cited by 5 publications

References 17 publications

Different mechanisms for the inhibition of progesterone secretion by ACTH and corticosterone in pregnant rats

Different mechanisms for the inhibition of progesterone secretion by ACTH and corticosterone in pregnant rats

Selective Apoptosis of Luteal Endothelial Cells in Dexamethasone-Treated Rats Leads to Ischemic Necrosis of Luteal Tissue1

Plasma progesterone response following ACTH administration during mid-gestation in the pregnant Brahman heifer

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