Inhibitory Effects and Mechanisms of Electroacupuncture via Chronically Implanted Electrodes on Stress-Induced Gastric Hypersensitivity in Rats With Neonatal Treatment of Iodoacetamide

Zhou, Jingbo; Li, Shiying; Wang, Yinping; Foreman, Robert D.; Yin, Jieyun; Zhang, Shengsheng; Chen, Jiande D.Z.

doi:10.1111/ner.12602

Cited by 36 publications

(34 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A watch‐size digital stimulator (SNM‐FDC01, Ningbo Maida Medical Device, Inc., Ningbo, China) was used to deliver trains of pulses. The stimulation parameters for ST36 stimulator were set at 2 sec on and 3 sec off, pulse width of 0.5 msec, pulse frequency of 25 Hz, and amplitude of 2–10 mA (at the maximum level tolerated by the subject) based on previous studies ; for PC6, stimulator was set at 0.1 sec on and 0.4 sec off, pulse width of 0.5 msec, pulse frequency of 100 Hz, and amplitude of 2–10 mA, which were shown to improve nausea and vomiting, and visceral pain . The bilateral stimulation TN treatment was given for half hour, twice daily (once on the day of surgery), lasting for 4 days.…”

Section: Methodsmentioning

confidence: 99%

Needleless Transcutaneous Neuromodulation Accelerates Postoperative Recovery Mediated via Autonomic and Immuno-Cytokine Mechanisms in Patients With Cholecystolithiasis

Zhang

Zhu²,

et al. 2019

Neuromodulation: Technology at the Neural Interface

Self Cite

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Needleless Transcutaneous Neuromodulation Accelerates Postoperative Recovery Mediated via Autonomic and Immuno-Cytokine Mechanisms in Patients With Cholecystolithiasis

Zhang

Zhu²,

et al. 2019

Neuromodulation: Technology at the Neural Interface

Self Cite

View full text Add to dashboard Cite

“…For example, alternative uses of 2 and 100 Hz stimulation are commonly used for treating pain due to different effects of low‐frequency and high‐frequency stimulations on enkephalin and endorphin . A combinational use of 2 and 100 Hz stimulation has been shown to be effective in reducing chemotherapy‐induced nausea and vomiting, and treating visceral pain . Low‐frequency stimulation is commonly used in cardiac applications .…”

Section: Types Of Electroacupuncture and Its Deliverymentioning

confidence: 99%

“…In addition to its prokinetic effects, EA is also known to have an analgesic effect. A few major mechanisms involved in the analgesic effect of EA on visceral pain or hypersensitivity have been reported: sensory afferent mechanisms involving dorsal root ganglions and opioid mechanisms and vagally mediated mechanisms . It should also be noted that EA stimulation parameters for treating visceral pain may be distinctly different from those used for treating gut dysmotility …”

Section: Mechanisms Of Electroacupuncturementioning

confidence: 99%

“…19 A combinational use of 2 and 100 Hz stimulation has been shown to be effective in reducing chemotherapy-induced nausea and vomiting, and treating visceral pain. 20,21 Low-frequency stimulation is commonly used in cardiac applications. 22 Based on our experience, a stimulation frequency in the range of 15-25 Hz seems best for the enhancement of gastrointestinal motility.…”

Section: Stimulation Parametersmentioning

confidence: 99%

“…38 It should also be noted that EA stimulation parameters for treating visceral pain may be distinctly different from those used for treating gut dysmotility. 21,39…”

Section: Mechanis Ms Of Elec Troacupun C Turementioning

confidence: 99%

See 2 more Smart Citations

Electroacupuncture treatments for gut motility disorders

Chen¹,

Yin³

2018

Neurogastroenterology Motil

View full text Add to dashboard Cite

Functional gastrointestinal (GI) diseases are common and there are patients who are refractory to medical therapies as not all treatments work in all patients. Consequently, a large number of patients with functional GI diseases use complementary and alternative medicine, such as acupuncture or electroacupuncture (EA). In this issue, Zheng et al. reported interesting results of a multi-center placebo-controlled clinical study on the use of EA for treating refractory functional dyspepsia; another study reported a multi-center clinical trial on EA for chronic functional constipation; Liang et al. studied mechanisms of EA involving enteric nervous system and neurotransmitters in treating constipation in rats. While controversial reports are available in the literature, EA with appropriate methodologies as shown in these recent studies is believed to be effective in treating certain functional GI diseases. In this mini-review, a number of clinical studies, including those included in this issue on the use of EA for treating gastro-esophageal reflux, functional dyspepsia, irritable bowel syndrome, and constipation are reviewed. Some critically important issues, such as the choice of stimulation parameters for EA, the administration frequency of the therapy, and the appropriate choice of placebo for clinical research are also discussed. Mechanisms of action involved in the therapeutic effects of EA for gut dysmotility and future research directions are also presented.

show abstract

Electroacupuncture restores intestinal mucosal barrier through TLR4/NF‐κB p65 pathway in functional dyspepsia‐like rats

Wang

Zhang

Yang

et al. 2021

The Anatomical Record

View full text Add to dashboard Cite

Functional dyspepsia (FD) is a common functional gastrointestinal disorder with high morbidity. Electroacupuncture (EA) has been applied to treat FD for a long time. The aim of this study was to investigate the effects of EA and its mechanism about intestinal mucosal barrier in rodent model of FD. Male Sprague–Dawley rats were randomly divided into the control group and the model group. Then, the rats in model group were established to the FD model by multifactor interventions. In Experiment 1, qualified FD‐like rats were randomly divided into three groups: FD, EA, and acupuncture (AP) groups. The interventions of EA and AP lasted 14 days, food intake, and body weight were recorded every 5 days. In Experiment 2, qualified FD‐like rats were randomly divided into five groups: FD, EA, AP, EA + TAK242, and TAK242 groups. The interventions of EA and AP lasted 14 days, while TAK242 injection continued for 6 days. The rats were sacrificed for the measurement of serum Interleukin‐ 6 (IL‐6) and Tumor necrosis factor‐α (TNF‐α) assayed by ELISA. Western blotting was used to assess the expression of TLR4, Myd88, NF‐κB p65, p‐NF‐κB p65, TRAF6, ZO‐1, and occludin in the duodenum. The transmission electron microscope was used to observe the ultrastructure of intestinal epithelial cells. Compared with the rats in the group FD, the rats in EA group had significantly increase of body weight, food intake, and protein expressions of ZO‐1 and occludin, while expressions of TLR4, Myd88, NF‐κB p65, p‐NF‐κB p65, TRAF6 in the duodenum and IL‐6, and TNF‐α in serum were decreased. The EA + TAK242 treatment had similar effects to the EA treatment but with increased potency; compared with EA, AP showed similar but reduced effects. Our data demonstrated that EA is more effective than AP in improving intestine mucosal barrier. The possible mechanisms of EA may involve the TLR4/NF‐κB p65 pathway.

show abstract

Inhibitory Effects and Mechanisms of Electroacupuncture via Chronically Implanted Electrodes on Stress-Induced Gastric Hypersensitivity in Rats With Neonatal Treatment of Iodoacetamide

Cited by 36 publications

References 43 publications

Needleless Transcutaneous Neuromodulation Accelerates Postoperative Recovery Mediated via Autonomic and Immuno-Cytokine Mechanisms in Patients With Cholecystolithiasis

Needleless Transcutaneous Neuromodulation Accelerates Postoperative Recovery Mediated via Autonomic and Immuno-Cytokine Mechanisms in Patients With Cholecystolithiasis

Electroacupuncture treatments for gut motility disorders

Electroacupuncture restores intestinal mucosal barrier through TLR4/NF‐κB p65 pathway in functional dyspepsia‐like rats

Contact Info

Product

Resources

About