Inhibitory Effect of Zirconium Coating to Bone Bonding of Titanium Implants in Rat Femur

Takada, Ryohei; Jinno, Tetsuya; Tsutsumi, Yusuke; Doi, Hisashi; Hanawa, Takao; Okawa, Atsushi

doi:10.2320/matertrans.m2016293

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…This confirms the capability of Ti for the spontaneous bone formation onto it when it is in the bone [55]. However, the Ca-P layer does not form on the surface of the zirconium alloy, but forms zirconium phosphate, which is preferential on Zr, and is protective and stable [18]. When Zrbased thin films were used for modification of surfaces of Ti, the capability of Ca-P forming on Ti was hindered, and without calcium, only phosphate or zirconium phosphate was formed.…”

Section: Discussionsupporting

confidence: 67%

“…In addition, the inhibitory effect of Zr coating on Ti alloy to bone bonding was evaluated by pull-out tests in vivo. Zr coating inhibits bone bonding with implanted Ti alloy in rat tibiae [18]. This technique may be useful to prevent the complications after implantation due to excessive bonding of Ti implants to surrounding bone, without losing any excellent mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

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Zirconium-based metallic glass and zirconia coatings to inhibit bone formation on titanium

et al. 2020

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Surface-modified commercially pure titanium (Cp-Ti) with zirconium (Zr)-based thin film metallic glasses (Zr-TFMGs) and ZrO2 thin films were surgically implanted into the tibiae of rats; the bone formation was analyzed to examine the performance of the coatings as a biomaterial. Zr-TFMGs and ZrO2 thin films were coated on Cp-Ti substrates to monitor the control of assimilation in vitro and in vivo. The microstructural and elemental analyses were carried out for the as deposited thin films by x-ray diffraction (XRD), transmission electron microscopy and x-ray photoelectron spectroscopy. TFMG- and ZrO2-coated Ti specimens were immersed in simulated body fluid (SBF) for a period of 21 days to evaluate the calcium phosphate precipitation in vitro. XRD, x-ray photoelectron spectroscopy and scanning electron microscopy/energy dispersive x-ray spectroscopy were used to quantify the mineralization on the coated Zr-TFMG and ZrO2. In vitro corrosion studies showed that the Zr-based TFMG and ZrO2 coatings sustained in the SBF, exhibited superior corrosion resistance to the bare crystalline Ti substrate. Wettability studies showed TFMG and ZrO2 coatings with a hydrophobic nature, and the TFMG-coated SBF-submerged specimens showed a hydrophilic nature. The in vitro cell viability of MC3T3-E1 cells showed good cell proliferation and low cytotoxicity. The calcification deposits were evaluated by staining with alizarin red S, which showed a lower calcium formation on Zr-TFMG compared to ZrO2. The present work also aims to assess the assimilation behavior of Cp-Ti, Zr-TFMG and ZrO2 in vivo by inserting the coated specimen in the femur of rats. After post-implantation of 8 weeks, specimens were examined by micro-CT evaluation. The bone contact ratios as calculated were 72.75%, 15.32% and 38.79%. Consequently, the bone affinity was Cp-Ti wire >ZrO2-coated Ti wire >Zr48Cu36Ag8Al8-coated Ti wire.

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Zirconium-based metallic glass and zirconia coatings to inhibit bone formation on titanium

et al. 2020

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“…CaP formation can be suppressed by coating the Ti surface with Zr, which inhibits CaP formation 28) and osteogenesis on Ti6Al4V alloy implanted in the tibia of rats. 29) 5. Surface Treatment 5.1 Transition and future prospects of surface treatments There are many positive remarks on surface treatments for their potential medical applications.…”

Section: Surface Oxide Film and Calcium Phosphate Formationmentioning

confidence: 99%

Metals and Medicine

Hanawa

2021

Mater. Trans.

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The research and development of metallic biomaterials and their future prospects are overviewed. Approximately 80% of implant devices and 95% of orthopedic devices are still made of metal, and metallic materials therefore continue to play an important role in medical treatment. Current research efforts in metallic biomaterials can be summarized into the following categories: the elucidation of interfacial reactions between metals and tissues (including evaluations of safety and corrosion resistance); the development of new surface treatment techniques (including the control of surface morphology); the development of new alloys; and the development of new manufacturing processes. Interfacial reactions between metals and living tissues are discussed from the viewpoints of biocompatibility and biofunction, corrosion resistance, and calcium phosphate formation on the surface oxide film. The transitions taking place in the surface treatments for osteogenesis, soft tissue adhesion, antibacterial property, and antithrombotic property are summarized, followed by a discussion of their future prospects. In addition, the concept of a dual-functional surface is explained. A review is done of zirconium alloys that decrease magnetic resonance imaging (MRI) artifacts, Ni-free austenitic stainless steel, high-pressure torsion and sliding processing, and additive manufacturing. Finally, the future of biomaterials research is considered.

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“…[ 266–268 ] Recently, Takada et al described a study built on the inhibitory effects of zirconium coating on titanium bone bonding in the rat femur. [ 269 ] Ti implants and Zr‐coated Ti implants were implanted in the left and right femur for evaluating these effects. After 4 weeks, the femurs and implants were removed, and a pull‐out test was used to estimate the shear strength of both the implants with bone.…”

Section: High‐performance Biomedical Applications Of Multimodel Zr‐nssmentioning

confidence: 99%

Emerging Multimodel Zirconia Nanosystems for High‐Performance Biomedical Applications

Rathee

Bartwal

Rathee

et al. 2021

Advanced NanoBiomed Research

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Advancement in nanotechnology supports system development to achieve rapid, affordable, and intelligent health management and has raised the urgent demand to explore multimodel affordable metal oxide nanostructures with the features of biocompatible tunable performance and scaled‐up processing. Keeping this as a motivation, zirconia nanostructures (Zr‐NSs) are emerging as nanostructures of choice for advanced biomedical applications due to affordable, scalable production, easy surface modifications, tunable surface morphology, multiphase stability, and acceptability by biological features such as biocompatibility, viability for bioactives, and a high isoelectric point of 9.5. Zr‐NSs, alone and in the form of hybrids, and nanocomposites have demonstrated notable high performance to develop next‐generation biosensors, implanted materials, and bioelectronics. However, their excellent salient features toward high‐performance biomedical system development are not well articulated in the form of a review. To overcome this knowledge gap, herein an attempt is made to summarize state‐of‐the‐art Zr‐NS preparation techniques as per targeted applications, surface functionalization of Zr‐NSs to achieve desired properties, and applications of Zr‐NSs in the field of biomedicine for health wellness. The challenges, possible solutions, and authors’ viewpoints considering prospects in mind are also part of this report.

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Inhibitory Effect of Zirconium Coating to Bone Bonding of Titanium Implants in Rat Femur

Cited by 8 publications

References 23 publications

Zirconium-based metallic glass and zirconia coatings to inhibit bone formation on titanium

Zirconium-based metallic glass and zirconia coatings to inhibit bone formation on titanium

Metals and Medicine

Emerging Multimodel Zirconia Nanosystems for High‐Performance Biomedical Applications

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