Inhibitory Effect of Zingerone on Secretory Group IIA Phospholipase A2

Lee, In-Chul; Kim, Dae Yong; Bae, Jong‐Sup

doi:10.1177/1934578x1701200624

Cited by 1 publication

(1 citation statement)

References 45 publications

(67 reference statements)

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“…Previous reports showed that treatment of cells or mice with ZGR inhibited LPS-induced expression and activity of sPLA2-IIA which contributes to vascular inflammation (16) and ZGR has anti-platelet aggregation activity (17). In those studies, ZGR was used from at 10 μM to 50 μM in human endothelial cells and from at 0.14, 0.36, or 0.72 mg/kg in mice (16, 17). Therefore, in this study, ZGR was also used from 0.07 to 0.72 mg/kg.…”

Section: Resultsmentioning

confidence: 99%

Renal protective effects of zingerone in a mouse model of sepsis

Lee

Yang

et al. 2019

BMB Rep.

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Zingerone (ZGR), a phenolic alkanone isolated from ginger, has been reported to possess pharmacological activities such as anti-inflammatory and anti-apoptotic effects. This study was initiated to determine whether ZGR could modulate renal functional damage in a mouse model of sepsis and to elucidate the underlying mechanisms. The potential of ZGR treatment to reduce renal damage induced by cecal ligation and puncture (CLP) surgery in mice was measured by assessment of serum creatinine, blood urea nitrogen (BUN), lipid peroxidation, total glutathione, glutathione peroxidase activity, catalase activity, and superoxide dismutase activity. Treatment with ZGR resulted in elevated plasma levels of BUN and creatinine, and of protein in urine in mice with CLP-induced renal damage. Moreover, ZGR inhibited nuclear factor-κB activation and reduced the induction of nitric oxide synthase and excessive production of nitric acid. ZGR treatment also reduced the plasma levels of interleukin-6 and tumor necrosis factor-α, reduced lethality due to CLP-induced sepsis, increased lipid peroxidation, and markedly enhanced the antioxidant defense system by restoring the levels of superoxide dismutase, glutathione peroxidase, and catalase in kidney tissues. Our study showed renal suppressive effects of zingerone in a mouse model of sepsis, suggesting that ZGR protects mice against sepsis-triggered renal injury.

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