Inhibitory effect of vitamins C and E on the oxygen free radical production in human polymorphonuclear leucocytes

Herbaczyńska-Cedro, K; Wartanowicz, M; Panczenko-Kresowska, B; Cedro, Krzysztof; Kłosiewicz-Wąsek, Beata; Wąsek, Wojciech

doi:10.1111/j.1365-2362.1994.tb01091.x

Cited by 31 publications

(13 citation statements)

References 22 publications

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“…In another study [9], ·-tocopherol supplementation for 3 months failed to exert any significant effect on either whole blood CL or migration of the patients' neutrophils. On the other hand, a decrease in the CL has also been reported in isolated leukocytes after oral supplementation with vitamin E in volunteers [10]. A transient inhibition of the PMAactivated luminol CL during administration of vitamin E was shown in another study [11].…”

Section: Discussionmentioning

confidence: 88%

Effect of Stobadine on Leukocyte Free Radical Generation in Streptozotocin-Diabetic Rats: Comparison with Vitamin E

et al. 2003

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We investigated a possible alteration in the ability of leukocytes to produce reactive oxygen species by stobadine, a pyridoindole antioxidant, in streptozotocin-diabetic rats. The production of free radicals from whole blood was assessed by luminol-enhanced chemiluminescence after stimulation by phorbol myristate acetate. The effects of vitamin E treatment were also evaluated and compared with the effects of combined treatment with stobadine. Diabetes was induced by streptozotocin (55 mg/kg i.p.). Some of diabetic rats and their age-matched controls were treated orally with a low dose of stobadine (24.7 mg/kg/day), vitamin E (400–500 IU/kg/day), or stobadine plus vitamin E for 10 weeks. Stobadine and vitamin E separately produced, to a similar degree, a reduction in diabetes-induced hyperglycemia. The phorbol myristate acetate stimulated chemiluminescence signal was markedly depressed in both moderate and severe diabetic rats. Stobadine treatment prevented this depression of the chemiluminescence response. Vitamin E treatment also eliminated the depression of the chemiluminescence signal in diabetic rats, and the combination with stobadine did not produce further improvement in leukocyte function. These results suggest that stobadine treatment alone is able to produce beneficial effects on leukocyte function and to maintain leukocyte free radical release during diabetes.

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Section: Discussionmentioning

confidence: 88%

Effect of Stobadine on Leukocyte Free Radical Generation in Streptozotocin-Diabetic Rats: Comparison with Vitamin E

et al. 2003

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“…Still, Kearns et al [29] documented that pretreatment with oral vitamin C relieves endothelial injury against acute muscle I/R injury as an antioxidant agent possibly by attenuating neutrophil respiratory burst activity. Herbaczynska-Cedro et al [30] demonstrated that vitamin C reduces oxygen free radicals production in human circulating neutrophils. For this reason, we included vitamin C to compare with iloprost effect in this study.…”

Section: Discussionmentioning

confidence: 98%

The Effects of Iloprost and Vitamin C on Kidney as a Remote Organ After Ischemia/Reperfusion of Lower Extremities

Özcan¹,

Saçar²,

Aybek³

et al. 2007

Journal of Surgical Research

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“…11 It decreases both the generation of oxygen free radicals by neutrophils and subsequent lipid peroxidation. 9,34,35 The systemic nature of the activity of vitamin C is shown by the reduction in circulating neutrophil respiratory burst after five days of oral treatment. By lowering the proinflammatory activity of neutrophils distant to the site of injury, pretreatment with vitamin C may decrease subsequent tissue damage when these neutrophils are chemoattracted to the site of IRI.…”

Section: Discussionmentioning

confidence: 99%

Oral vitamin C attenuates acute ischaemia-reperfusion injury in skeletal muscle

Kearns

Moneley

Murray

et al. 2001

The Journal of Bone and Joint Surgery. British volume

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I schaemia-reperfusion injury (IRI) is caused byendothelial and subendothelial damage by neutrophil-derived oxidants. Vitamin C is an antioxidant which attenuates endothelial injury after IRI. Our aim was to evaluate the effect of oral vitamin C in the prevention of IRI in skeletal muscle. We used a model of cross-clamping (3 hours) and reperfusion (1 hour) of the cremaster muscle in rats. Muscle function was assessed electrophysiologically by electrical field stimulation. Infiltration by neutrophils was determined by the activity of tissue myeloperoxidase (MPO) and tissue oedema by the wet-to-dry ratio. Neutrophil respiratory burst activity was measured in control animals and groups pretreated with vitamin C.IRI significantly decreased muscle function and increased muscle neutrophil MPO activity and muscle oedema. Pretreatment with vitamin C preserved muscle function and reduced tissue oedema and neutrophil infiltration. Neutrophil respiratory burst activity was reduced in the group treated with vitamin C compared with the control group.We conclude that pretreatment with oral vitamin C protects against acute muscle IRI, possibly by attenuating neutrophil respiratory burst activity.

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Inhibitory effect of vitamins C and E on the oxygen free radical production in human polymorphonuclear leucocytes

Cited by 31 publications

References 22 publications

Effect of Stobadine on Leukocyte Free Radical Generation in Streptozotocin-Diabetic Rats: Comparison with Vitamin E

Effect of Stobadine on Leukocyte Free Radical Generation in Streptozotocin-Diabetic Rats: Comparison with Vitamin E

The Effects of Iloprost and Vitamin C on Kidney as a Remote Organ After Ischemia/Reperfusion of Lower Extremities

Oral vitamin C attenuates acute ischaemia-reperfusion injury in skeletal muscle

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