Inhibitory Effect of Triterpenoid Saponins from the Leaves of<i>Ilex kudingcha</i>on Aggregated LDL-Induced Lipid Deposition in Macrophages

Zheng, Jiao; Tang, Li; Xian, Xunde; Zhou, Si Xiang; Shi, Huicheng; Jiang, Yong; Gu, Yue; Liu, George; Tu, Peng

doi:10.1055/s-0029-1185722

Cited by 26 publications

(13 citation statements)

References 7 publications

(9 reference statements)

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“…The OH group at the C-12 position, the number of monosaccharides in the sugar chain, and the presence of a terminal rhamnose residue in the sugar chain might improve this inhibitory effect. Moreover, compound 64 was considered as a potential candidate for the treatment of arteriosclerosis [53]. …”

Section: Biological Activitiesmentioning

confidence: 99%

The large-leaved Kudingcha (Ilex latifolia Thunb and Ilex kudingcha C.J. Tseng): a traditional Chinese tea with plentiful secondary metabolites and potential biological activities

et al. 2013

J Nat Med

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In China, Kudingcha has been used for almost 2,000 years as a tea to quench thirst, remove phlegm, refresh the mind, and improve eyesight. The group of large-leaved Kudingcha is coveted for its potential effects on lipid metabolism, which are attributed to the presence of characteristic ingredients. This contribution reviews studies from the past few decades regarding the plant characteristics, ethnobotanical usages, chemical constituents, and related biological activities of the large-leaved Kudingcha (Ilex latifolia Thunb and Ilex kudingcha C.J. Tseng). Triterpenoids, phenolic acids, flavonoids, and essential oils are the main metabolites in the large-leaved Kudingcha, and these ingredients protect the vascular system, regulate lipid metabolism, and have antioxidant, hypoglycemic, and anti-tumor effects. Moreover, large-leaved Kudingcha shares several properties with the popular green tea and the Yerba maté from South America.

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Section: Biological Activitiesmentioning

confidence: 99%

The large-leaved Kudingcha (Ilex latifolia Thunb and Ilex kudingcha C.J. Tseng): a traditional Chinese tea with plentiful secondary metabolites and potential biological activities

et al. 2013

J Nat Med

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“…11,12 Recently, more studies have been devoted to the extraction and identication of main chemicals in I. latifolia such as avonoids, saponins, polysaccharides and alkaloids and their potential health benets in antioxidant, anti-obesity, neuroprotective, antidiabetic, hepatoprotective and anticomplementary effects. [11][12][13] However, little attention has been paid to the extraction and bioactivities of polyphenols of I. latifolia. Therefore, searching for alternative natural active ingredients such as polyphenols in I. latifolia is necessary for its application on food additives and health products.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and anti-inflammatory effects of polyphenols extracted fromIlex latifoliaThunb

Zhang

Jiang

et al. 2018

RSC Adv.

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“…The total saponins from ilex kuding tea improve abnormal hemorheological parameters in ApoE −/− mice induced by a high-fat diet [14]. Triterpenoid saponins from the leaves of ilex kuding tea inhibit the LDL-induced formation of foam cells and reduce intracellular total cholesterol and triglyceride contents [15]. However, there is no solid experimental data to support the effects of kuding tea on obesity and hyperlipidemia.…”

Section: Introductionmentioning

confidence: 99%

Extract of Kuding Tea Prevents High-Fat Diet-Induced Metabolic Disorders in C57BL/6 Mice via Liver X Receptor (LXR) β Antagonism

Fan

Zhang

et al. 2012

PLoS ONE

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ObjectiveTo investigate the effects of ilex kudingcha C. J. Tseng (kuding tea), a traditional beverage in China, on the metabolic disorders in C57BL/6 mice induced by high-fat diets.DesignFor the preventive experiment, the female C57BL/6 mice were fed with a standard diet (Chow), high-fat diet (HF), and high-fat diet mixed with 0.05% ethanol extract of kuding tea (EK) for 5 weeks. For the therapeutic experiment, the C57BL/6 mice were fed high-fat diet for 3 months, and then mice were split and EK was given with oral gavages for 2 weeks at 50 mg/day/kg. Body weight and daily food intake amounts were measured. At the end of treatment, the adipocyte images were assayed with a scanning electron microscope, and the fasting blood glucose, glucose tolerance test, serum lipid profile and lipids in the livers were analyzed. A reporter gene assay system was used to test the whether EK could act on nuclear receptor transcription factors, and the gene expression analysis was performed with a quantitative PCR assay.ResultsIn the preventive treatment, EK blocked the body weight gain, reduced the size of the adipocytes, lowered serum triglyceride, cholesterol, LDL-cholesterol, fasting blood glucose levels and glucose tolerance in high-fat diet-fed C57BL/6 mice. In the therapeutic treatment, EK reduced the size of the white adipocytes, serum TG and fasting blood glucose levels in obese mice. With the reporter assay, EK inhibited LXRβ transactivity and mRNA expression of LXRβ target genes.ConclusionWe observed that EK has both preventive and therapeutic roles in metabolic disorders in mice induced with high-fat diets. The effects appear to be mediated through the antagonism of LXRβ transactivity. Our data indicate that kuding tea is a useful dietary therapy and a potential source for the development of novel anti-obesity and lipid lowering drugs.

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Inhibitory Effect of Triterpenoid Saponins from the Leaves ofIlex kudingchaon Aggregated LDL-Induced Lipid Deposition in Macrophages

Abstract: Ilex kudingcha l " Aquifoliaceae l " anti-atherosclerosis l " structure-activity relationship l " foam cells l " triterpenoid saponins

Cited by 26 publications

References 7 publications

The large-leaved Kudingcha (Ilex latifolia Thunb and Ilex kudingcha C.J. Tseng): a traditional Chinese tea with plentiful secondary metabolites and potential biological activities

The large-leaved Kudingcha (Ilex latifolia Thunb and Ilex kudingcha C.J. Tseng): a traditional Chinese tea with plentiful secondary metabolites and potential biological activities

Antioxidant and anti-inflammatory effects of polyphenols extracted fromIlex latifoliaThunb

Extract of Kuding Tea Prevents High-Fat Diet-Induced Metabolic Disorders in C57BL/6 Mice via Liver X Receptor (LXR) β Antagonism

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