Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin

Huang, Mou‐Tuan; Ho, Chi‐Tang; Wang, Zhi Yuan; Ferraro, Thomas; Finnegan-Olive, Tara; Lou, You-Rong; Mitchell, John M.; Laskin, Jeffrey D.; Newmark, Harold L.; Yang, Chung S.; Conney, Allan H.

doi:10.1093/carcin/13.6.947

Cited by 200 publications

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“…The anticarcinogenic activities of tea polyphenols are believed to be closely related to their antioxidative properties. The findings that green tea preparations inhibited 12-0-tetradecanoylphorbol-1 3-acetate-induced hydrogen peroxide formation in mouse epidermis (62) and NNK-induced 8-hydroxydeoxyguanosine formation in mouse lung (20) are consistent with this concept. Inhibition of tumor promotion-related enzymes such as ornithine decarboxylase (62,63), protein kinase C (64), lipoxygenase, and cyclooxygenase (19) by tea preparations has also been reported.…”

Section: Possible Mechanisms For the Inhibition Of Tumorigenesismentioning

confidence: 58%

“…The findings that green tea preparations inhibited 12-0-tetradecanoylphorbol-1 3-acetate-induced hydrogen peroxide formation in mouse epidermis (62) and NNK-induced 8-hydroxydeoxyguanosine formation in mouse lung (20) are consistent with this concept. Inhibition of tumor promotion-related enzymes such as ornithine decarboxylase (62,63), protein kinase C (64), lipoxygenase, and cyclooxygenase (19) by tea preparations has also been reported. Although inhibition of carcinogen activation by tea or green tea polyphenol fractions could be demonstrated in vitro and, in certain cases, in vivo (65,66), this mechanism was not demonstrated for NNK bioactivation in vivo (18,20).…”

Section: Possible Mechanisms For the Inhibition Of Tumorigenesismentioning

confidence: 58%

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Polyphenols As Inhibitors of Carcinogenesis

Yang¹,

Lee²,

Chen³

et al. 1997

Environmental Health Perspectives

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Many polyphenolic compounds have demonstrated anticarcinogenic activities in animal models. These compounds include flavanone, flavonols, isoflavone, and catechins. In this article, tea catechins will be used as an example to illustrate current research in this area. Many laboratory studies have demonstrated the inhibition of tumorigenesis in animal models by different tea preparations. The animal models include tumorigenesis in the mouse lung, rat and mouse esophagi, mouse forestomach, mouse skin, mouse duodenum, rat small intestine, rat and mouse livers, and rat colon. In most of the studies, the inhibitory activity of tea could be demonstrated when tea preparations were given either during or after the carcinogen treatment period. Black tea was also effective, although the activity was weaker than green tea in some experiments. Decaffeinated tea preparations were also active in many model systems. The molecular mechanisms for these broad inhibitory actions are not fully understood. They are most likely related to the biochemical actions of the tea polyphenols, which include antioxidative activities and inhibition of cell proliferation and of tumor promotion-related activities. The effect of tea consumption on human cancers is not clear in spite of numerous investigations. The bioavailability and pharmacokinetics of tea polyphenols are being studied in animals and humans to provide a basis for more quantitative analyses on the effect of tea on carcinogenesis. More mechanistic and dose-response studies will help us to understand the effects of tea consumption on human carcinogenesis. Environ Health Perspect 105(Suppl 4): 971-976 (1997)

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Section: Possible Mechanisms For the Inhibition Of Tumorigenesismentioning

confidence: 58%

Section: Possible Mechanisms For the Inhibition Of Tumorigenesismentioning

confidence: 58%

Polyphenols As Inhibitors of Carcinogenesis

Yang¹,

Lee²,

Chen³

et al. 1997

Environmental Health Perspectives

Self Cite

View full text Add to dashboard Cite

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“…Antioxidants are reported to act as protective agents against cancer [28][29][30][31]. Antioxidants act as the primary line of defense against ROS and suggest their usefulness in eliminating the risk of oxidative damage induced during carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Anti-tumor and Anti-oxidative Activity of Rosmarinus officinalis in 7, 12 Dimethyl Benz(a) Anthracene Induced Skin Carcinogenesis in Mice

Parmar¹,

Verma²,

Goyal³

2011

Am. J. Biomed. Sci.

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The present investigation was undertaken to explore the antitumor-promoting activity of R.officinalis on 2-stage skin carcinogenesis, induced by a single topical application of 7,12-dimethylbenz(a)anthracene and promoted by repeated treatment of croton oil for 16 weeks in Swiss albino mice. Oral administration of R.officinalis leaves extract, during the peri-and post-initiation stage induced by 7,12-dimethylbenz[a]anthracene (DMBA), reduced the tumor burden to 2.6 (positive control value: 5.16); cumulative number of papillomas to 13 (positive control value: 62) and percent incidence of mice bearing papillomas to 41.66 %, (positive control value: 100%). A significant (p<0.001) decreased was observed in Lipid peroxidation level by the administration of ROE. Reduced glutathione (GSH) and total proteins was found to be significantly elevated in liver and skin (p < 0.001) of mice in ROE treated group. Skin and liver of R.officinalis treated group animals showed a significant enhancement in antioxidant enzymes like superoxide dismutase (SOD) and Catalase, when compared with the carcinogen treated control. These studies indicate that R.officinalis could reduce the chemical induced tumor and oxidative stress during skin carcinogenesis.

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“…Green tea polphenols have also been shown to inhibit tumorgenesis and carcinogenesis. The anticarcinogenic action of green tea and its constituents, particularly EGCG, has been studied in vivo in human body and animals [6][7][8].…”

Section: Anti-cancer Effect Of Tea Polyphenols and Their Mechanismsmentioning

confidence: 99%

The Health Effects of Tea Polyphenols and Their Antioxidant Mechanism

Zhao

2006

J. Clin. Biochem. Nutr.

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Summary There are thousands year of history for drinking tea in China and world. The benefits of drinking tea to human health are well known and improved by epidemiological result and experiments. The most effective components in tea are polyphenols which are about 30% weight of dry tea. The antitumor and antimutagenic effects of the tea polyphenols, the prevent effect of the tea polyphenols on Alzheimer's disease and Parkinson's disease, the protective effects of the tea polyphenols on neuron against lead toxicity and their antioxidant mechanisms are reviewed and discussed in this paper.

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Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin

Cited by 200 publications

References 0 publications

Polyphenols As Inhibitors of Carcinogenesis

Polyphenols As Inhibitors of Carcinogenesis

Anti-tumor and Anti-oxidative Activity of Rosmarinus officinalis in 7, 12 Dimethyl Benz(a) Anthracene Induced Skin Carcinogenesis in Mice

The Health Effects of Tea Polyphenols and Their Antioxidant Mechanism

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