Inhibitory Effect of TNP-470 on Hepatic Metastasis of Mouse Neuroblastoma

Yoshizawa, Jyoji; Mizuno, Ryoji; Yoshida, Tsuginori; Hara, Akihiko; Ashizuka, Syuichi; Kanai, Masaki; Kuwashima, Naruo; Kurobe, Masashi; Yamazaki, Yoji

doi:10.1006/jsre.2000.5956

Cited by 16 publications

(6 citation statements)

References 14 publications

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“…It is known that ~50% patients with advanced or recurrent malignant tumors develop varying degrees of malignant ascites ( 19 ). Once this occurs, the survival of patients is usually ~5–7 months ( 20 ). For gastroenteric tumors, peritoneal or abdominal visceral metastasis is the primary cause of tumor recurrence and is a key prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of antimicrobial peptide on malignant ascites in a mouse model

et al. 2018

Mol Med Report

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The primary objective of the treatment of malignant ascites in advanced stages is to alleviate symptoms using procedures such as diuresis, paracentesis of subretinal fluid and vena cava anastomosis. The effectiveness of systemic or intraperitoneal chemotherapy treatment is limited, and more efficacious therapies are required. The authors of the present study demonstrated that an antimicrobial peptide, cecropinXJ, isolated from the larvae of Bombyx mori, selectively inhibits the proliferation of gastric cancer cells. However, the effects of antibacterial peptides on gastric ascites tumor remains unclear. In the present study, the therapeutic effects of cecropinXJ were investigated in mice bearing malignant ascites. Compared with bovine serum albumin treatment, cecropinXJ and doxorubicin (Dox) significantly inhibited the formation and growth of malignant ascites, and prolonged the survival time of ascites tumor-bearing mice. In addition, cecropinXJ treatment normalized the hematological and biochemical phenotypes, induced tumor cell apoptosis in ascites and improved the survival of mice bearing malignant ascites when compared with Dox treatment. These results suggested that cecropinXJ might be a promising therapeutic candidate for the treatment of gastric cancer-associated ascites.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effects of antimicrobial peptide on malignant ascites in a mouse model

et al. 2018

Mol Med Report

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“…Among them, in the '90s, TNP-470, an angiogenesis inhibitor, has emerged as a promising adjuvant in dormancy therapies for high-risk neuroblastoma. In particular, its effectiveness in arresting hepatic metastasis of neuroblastoma has been documented in [97] and [98]. In the light of [99], the antiangiogenic activity of TNP-470 is reasonably linked to its interference with the hepatic copper metabolism.…”

Section: Anti-angiogenic Therapies Target the Neuroblastoma Copper Stmentioning

confidence: 99%

Copper as a Target for Treatment of Neuroblastoma: Molecular and Cellular Mechanisms

Urso¹,

Maffia²

2013

Neuroblastoma

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Neuroblastoma 266 Copper uptake Ctr1 (Copper transporter 1). High-affinity Cu + importer, composed of three main domains: an extracellular N-terminal tail containing multiple copper-binding methionine residues; a transmembrane segment consisting of three α-helical regions; an intracellular C-terminal domain. Three subunits assemble to form a homo-trimeric channel (9 Å pore diameter) within the plasma membrane (see [118] for a review). Ctr2 (Copper transporter 2). Copper permease, whose structure resembles that of Ctr1. Predominantly localized to endosomes and lysosomes, it seems to provide a mechanism of copper recycling from degraded cuproenzymes [119]. PrP C (Cellular Prion protein). Endogenous copper-binding glycoprotein, mainly expressed in the central nervous system. The protein structure includes an unstructured N-terminal domain and a Cterminal globular region composed of three α-helices and two short beta-strands. When Cu 2+ ions bind to the N-terminal octapeptide repeats (residues 51-90), the protein undergoes endocytosis, that providing a route for cell copper entry [58,59]. Cytosolic transport CCS. Metallo chaperone required for copper delivery to Cu,Zn Superoxide dismutases 1; upregulated in response to copper deficiency [120]. Cox17. Metallo chaperone delivering copper to Sco1 and Cox11 proteins in order to catalyse the cytochrome c oxidase copper loading [121]. Atox1. Metallo chaperone that delivers copper to ATP7A and ATP7B Cu + efflux pumps [122]. Metallothioneins. Small cysteine-rich proteins tightly binding copper ions and buffering the ion excess [123]. Copper efflux ATP7A. Cu +-transporting P-type ATPase expressed by all cell types, with the exception of liver. Structural features include eight membrane-spanning domains and six N-terminal cysteine-rich metal binding motifs (MXCXXC) [25]. Box 1. Main proteins involved in cell copper homeostasis Neuroblastoma 268

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“…TNP-470 is a potent selective inhibitor of Methionine aminopeptidase-2 (MetAP-2) resulting in endothelial cell cycle arrest late in G1 phase and leading to inhibition of tumor angiogenesis [183]. TNP-470 treatment in a NB tumor xenograft model reduced the tumor growth rate and decreased capillary density [184][185][186][187][188], and increased the efficacy of chemotherapy [181]. Taken together, these results suggest that anti-angiogenesis is an effective approach for reducing NB growth and burden.…”

Section: Anti-angiogenesis Treatments In Nb -Conventional Anti-vegf/vmentioning

confidence: 99%

Endothelial and Accessory Cell Interactions in Neuroblastoma Tumor Microenvironment

Gershan¹,

Chan²,

Chrzanowska‐Wodnicka³

et al. 2013

Research Directions in Tumor Angiogenesis

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Inhibitory Effect of TNP-470 on Hepatic Metastasis of Mouse Neuroblastoma

Cited by 16 publications

References 14 publications

Therapeutic effects of antimicrobial peptide on malignant ascites in a mouse model

Therapeutic effects of antimicrobial peptide on malignant ascites in a mouse model

Copper as a Target for Treatment of Neuroblastoma: Molecular and Cellular Mechanisms

Endothelial and Accessory Cell Interactions in Neuroblastoma Tumor Microenvironment

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